Immunological activities are modulated by enteral administration of an elemental diet in mice

Elemental diets (EDs) have been used successfully in treatment of some intestinal inflammatory diseases; however, the mechanism that mediates their effects is still unclear. In this study we evaluated the immunological effect of enteral administration of an ED in mice. C57BL/6 mice were fed an ED (E...

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Bibliographic Details
Published in:	Clinical nutrition (Edinburgh, Scotland) Vol. 25; no. 4; pp. 643 - 652
Main Authors:	Menezes, Juscilene S., Andrade, Mariléia C., Senra, Beatriz, Rodrigues, Virlânia S., Vaz, Nelson M., Faria, Ana Maria C.
Format:	Journal Article
Language:	English
Published:	Kidlington Elsevier Ltd 01-08-2006 Elsevier
Subjects:	Animals Biological and medical sciences Elemental diet Enteral Nutrition Enzyme-Linked Immunosorbent Assay - methods Flow Cytometry - veterinary Food, Formulated GALT Immunoglobulin A - analysis Immunoglobulin G - analysis Immunohistochemistry - methods Immunoregulation Inflammatory bowel diseases Intestinal Mucosa - cytology Intestinal Mucosa - immunology Intestine, Small - cytology Intestine, Small - immunology Lymphocytes - immunology Lymphoid Tissue - cytology Lymphoid Tissue - growth & development Lymphoid Tissue - immunology Medical sciences Metabolic diseases Mice Mice, Inbred C57BL Mucosa Protein Spleen - cytology Spleen - immunology Weaning Inflammatory bowel diseases Elemental diet GALT Immunoregulation Mucosa Protein Vertebrata Mammalia Nutrition Diet Mouse Animal Rodentia Activity Enteral administration Feeding
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Summary:	Elemental diets (EDs) have been used successfully in treatment of some intestinal inflammatory diseases; however, the mechanism that mediates their effects is still unclear. In this study we evaluated the immunological effect of enteral administration of an ED in mice. C57BL/6 mice were fed an ED (El-Diet) from weaning up to adulthood and immunological parameters were analyzed. El-Diet-fed mice presented an underdeveloped gut-associated-lymphoid tissue with lower numbers of TCR αβ+IELs and lamina propria cells and low levels of secretory IgA when compared to chow-fed mice. They showed a systemic decrease in the production of IgG and IgA as well as a skewing towards a Th2 profile of cytokine production upon in vitro stimulation with an increase in IL-4 and a reduction in IFN- γ and IL-6 secretion. Our study demonstrated the role of EDs in modulating immunological activities in mice and proposes a rational for their successful use in treatment of some intestinal inflammatory diseases.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0261-5614 1532-1983
DOI:	10.1016/j.clnu.2006.01.005