Search Results - "Rodrigues, Oscar Endrigo"

Antiviral Effect of 5′-Arylchalcogeno-3-aminothymidine Derivatives in SARS-CoV-2 Infection by Tucci, Amanda Resende, da Rosa, Raquel Mello, Rosa, Alice Santos, Augusto Chaves, Otávio, Ferreira, Vivian Neuza Santos, Oliveira, Thamara Kelcya Fonseca, Coutinho Souza, Daniel Dias, Borba, Nathalia Roberto Resende, Dornelles, Luciano, Rocha, Nayra Salazar, Mayer, João Candido Pilar, da Rocha, João B. Teixeira, Rodrigues, Oscar Endrigo D, Miranda, Milene Dias

“…The understanding that zidovudine (ZDV or azidothymidine, AZT) inhibits the RNA-dependent RNA polymerase (RdRp) of SARS-CoV-2 and that chalcogen atoms can…”
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Polymer-coated palladium nanoparticle catalysts for Suzuki coupling reactions by Bortolotto, Tanize, Facchinetto, Sara Elisa, Trindade, Suelen Gauna, Ossig, Andreia, Petzhold, Cesar Liberato, Vargas, Josimar, Rodrigues, Oscar Endrigo Dorneles, Giacomelli, Cristiano, Schmidt, Vanessa

“…[Display omitted] •We report the use of polymer-coated palladium nanoparticles in catalysis.•The effect of polymer structure on the catalytic activity was…”
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Revitalizing the AZT Through of the Selenium: An Approach in Human Triple Negative Breast Cancer Cell Line by Wagner, Mônica Silveira, Schultze, Eduarda, Oliveira, Thais Larre, de Leon, Priscila Marques Moura, Thurow, Helena Strelow, Campos, Vinicius Farias, Oliveira, Isabel, de Souza, Diego, Rodrigues, Oscar Endrigo Dorneles, Collares, Tiago, Seixas, Fabiana Kömmling

“…Triple-negative breast cancer represents about 15% of all cases of breast cancer, and still represents a therapeutic challenge. 3'-Azido-3'-deoxythymidine…”
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Antibacterial effect of chalcogenoesters on planktonic cells and biofilms of Streptococcus mutans and Streptococcus parasanguinis by de Sousa, Leonardo Silva, Camara-Leimbach, Agena, de Vasconcelos, Mayron Alves, Arruda, Francisco Vassiliepe Sousa, da Silva, Rafael Santos, Dornelles, Luciano, Rodrigues, Oscar Endrigo Dorneles, Teixeira, Edson Holanda

“…The purpose of this work was to evaluate the antibacterial and antibiofilm activity of five chalcogenoesters synthetics on oral bacteria, Streptococcus mutans…”
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Evaluation of the effect of synthetic compounds derived from azidothymidine on MDA-MB-231 type breast cancer cells by Oliveira Rocha, Adriely Maria, Severo Sabedra Sousa, Fernanda, Mascarenhas Borba, Victoria, S. Munchen, Taiana, Guerin Leal, Julliano, Dorneles Rodrigues, Oscar Endrigo, G. Fronza, Mariana, Savegnago, Lucielli, Collares, Tiago, Kömmling Seixas, Fabiana

“…[Display omitted] The present study aimed to investigate the effect of AZT derivates containing tellurium (Te) on human breast cancer cell lines and the…”
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DNA nanovaccines prepared using LemA antigen protect Golden Syrian hamsters against Leptospira lethal infection by Oliveira, Thaís Larré, Bacelo, Kátia Leston, Forster, Karine Maciel, Ilha, Vinicius, Rodrigues, Oscar Endrigo, Hartwig, Daiane D

“…Nanoparticles (NPs) are viable candidates as carriers of exogenous materials into cells via transfection and can be used in the DNA vaccination strategy…”
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Biochemical and histological evaluations of anti-inflammatory and antioxidant p-chloro-selenosteroid actions in acute murine models of inflammation by Marcondes Sari, Marcel Henrique, Souza, Ana Cristina Guerra, Rosa, Suzan Gonçalves, Chagas, Pietro Maria, da Luz, Sônia Cristina Almeida, Rodrigues, Oscar Endrigo Dorneles, Nogueira, Cristina Wayne

“…This study investigated the potential p-chloro-selenosteroid (PCS) anti-inflammatory effect in different animal models of acute inflammation. In order to…”
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Anti‐Inflammatory and Anti‐Oxidant Effects of p‐Chloro‐phenyl‐selenoesterol on TNBS‐Induced Inflammatory Bowel Disease in Mice by Zarzecki, Micheli Stéfani, Bortolotto, Vandreza Cardoso, Poetini, Márcia Rósula, Araujo, Stífani Machado, de Paula, Mariane Trindade, Roman, Silvane Souza, Spiazzi, Cristiano, Cibin, Franciele Weber Santos, Rodrigues, Oscar Endrigo Dorneles, Jesse, Cristiano Ricardo, Prigol, Marina

“…ABSTRACT This study aims to investigate the protective effect of p‐chloro‐phenyl‐selenoesterol [PCS; 0,2 mg/kg; 10 ml/kg i.g.) in colitis induced by…”
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Co-Delivery of an Innovative Organoselenium Compound and Paclitaxel by pH-Responsive PCL Nanoparticles to Synergistically Overcome Multidrug Resistance in Cancer by Mathes, Daniela, Macedo, Letícia Bueno, Pieta, Taís Baldissera, Maia, Bianca Costa, Rodrigues, Oscar Endrigo Dorneles, Leal, Julliano Guerin, Wendt, Marcelo, Rolim, Clarice Madalena Bueno, Mitjans, Montserrat, Nogueira-Librelotto, Daniele Rubert

“…In this study, we designed the association of the organoselenium compound 5'-Seleno-(phenyl)-3'-(ferulic-amido)-thymidine (AFAT-Se), a promising innovative…”
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Antinociceptive and anti-hyperalgesic effects of bis(4-methylbenzoyl) diselenide in mice: evidence for the mechanism of action by Donato, Franciele, Pavin, Natasha Frasson, Goes, André Tiago Rossito, Souza, Leandro Cattelan, Soares, Letiére Cabreira, Rodrigues, Oscar Endrigo Dorneles, Jesse, Cristiano Ricardo, Savegnago, Lucielli

“…The organoselenium compounds have been described to demonstrate several biological activities, including pain management. This study investigated the…”
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Overcoming MDR by Associating Doxorubicin and pH-Sensitive PLGA Nanoparticles Containing a Novel Organoselenium Compound-An In Vitro Study by Macedo, Letícia Bueno, Nogueira-Librelotto, Daniele Rubert, Mathes, Daniela, de Vargas, Josiele Melo, da Rosa, Raquel Mello, Rodrigues, Oscar Endrigo Dorneles, Vinardell, Maria Pilar, Mitjans, Montserrat, Rolim, Clarice Madalena Bueno

“…In this study, we developed PLGA nanoparticles (NPs) as an effective carrier for 5'-Se-(phenyl)-3-(amino)-thymidine (ACAT-Se), an organoselenium compound,…”
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Free radical scavenging in vitro and biological activity of diphenyl diselenide-loaded nanocapsules: DPDS-NCS antioxidant and toxicological effects by Stefanello, Sílvio Terra, Dobrachinski, Fernando, de Carvalho, Nélson Rodrigues, Amaral, Guilherme Pires, Barcelos, Rômulo Pillon, Oliveira, Vitor Antunes, Oliveira, Cláudia Sirlene, Giordani, Camila Ferrazza Alves, Pereira, Maria Ester, Rodrigues, Oscar Endrigo Dorneles, Soares, Félix Alexandre Antunes

“…Selenium compounds, such as diphenyl diselenide (DPDS), have been shown to exhibit biological activity, including antioxidant effects. However, the use of DPDS…”
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Transferrin-Decorated PLGA Nanoparticles Loaded with an Organoselenium Compound as an Innovative Approach to Sensitize MDR Tumor Cells: An In Vitro Study Using 2D and 3D Cell Models by Macedo, Letícia Bueno, Nogueira-Librelotto, Daniele Rubert, Mathes, Daniela, Pieta, Taís Baldissera, Mainardi Pillat, Micheli, Rosa, Raquel Mello da, Rodrigues, Oscar Endrigo Dorneles, Vinardell, Maria Pilar, Rolim, Clarice Madalena Bueno

“…Multidrug resistance (MDR) is the main challenge in cancer treatment. In this sense, we designed transferrin (Tf)-conjugated PLGA nanoparticles (NPs)…”
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Biosafety assessment of novel organoselenium zidovudine derivatives in the Caenorhabditis elegans model by Baptista, Fabiane Bicca Obetine, da Silva, Aline Franzen, Cordeiro, Larissa Marafiga, de Souza, Larissa Ilha, da Silveira, Tássia Limana, Soares, Marcell Valandro, Michelotti, Paula, Corte, Cristiane Lenz Dalla, da Silva, Rafael Santos, Rodrigues, Oscar Endrigo Dorneles, Arantes, Leticia Priscilla, Soares, Félix Alexandre Antunes

“…Antiretrovirals have improved considerably since the introduction of 3′-azido-3′-deoxythymidine (zidovudine or AZT), a molecule with also anticancer effects…”
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Systematic screening of synthetic organochalcogen compounds with anticancer activity using human lung adenocarcinoma spheroids by Batista, Jéssica Eduarda dos Santos, Rodrigues, Mariele Borkowski, Bristot, Ivi Juliana, Silva, Valquíria, Bernardy, Silvia, Rodrigues, Oscar Endrigo Dorneles, Dornelles, Luciano, Carvalho, Fabiano Barbosa, de Sousa, Francisca Joseli Freitas, Fernandes, Marilda da Cruz, Zanatta, Geancarlo, Soares, Félix Alexandre Antunes, Klamt, Fábio

“…Lung adenocarcinoma stands as a leading global cause of cancer-related fatalities, with current therapeutic approaches remaining unsatisfactory. Given the…”
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Synthesis and application of new selanylfullerene derivatives as photosensitizers for photodynamic therapy by Soares, Letiére C, Vargas, Josimar, Ravanello, Bruno B, Ilha, Vinicius, Seus, Natalia, Santos da Silva, Rafael, Alves, Diego, Dornelles, Luciano, Villetti, Marcos A, da Rocha, Vinicius N, Piquini, Paulo C, Dorneles Rodrigues, Oscar Endrigo

“…This study aims to describe the synthesis of a new class of selanylfullerene derivatives in a convergent strategy route, affording the desired products in a…”
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Selenothymidine protects against biochemical and behavioral alterations induced by ICV-STZ model of dementia in mice by Thomé, Gustavo Roberto, Oliveira, Vitor Antunes, Chitolina Schetinger, Maria Rosa, Saraiva, Rogério Aquino, Souza, Diego, Dorneles Rodrigues, Oscar Endrigo, Teixeira Rocha, João Batista, Ineu, Rafael Porto, Pereira, Maria Ester

“…The present study evaluated the neuroprotective effects of one selenium-containing AZT derivative compound (S1073) in memory and learning impairment caused by…”
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In silico evidences of Mpro inhibition by a series of organochalcogen-AZT derivatives and their safety in Caenorhabditis elegans by Viçozzi, Gabriel Pedroso, de Oliveira Pereira, Flávia Suelen, da Silva, Rafael Santos, Leal, Julliano Guerin, Sarturi, Joelma Menegazzi, Nogara, Pablo Andrei, Rodrigues, Oscar Endrigo Dorneles, Teixeira da Rocha, João Batista, Ávila, Daiana Silva

“…The new coronavirus (SARS-CoV-2) pandemic emerged in 2019 causing millions of deaths. Vaccines were quickly developed and made available in 2021. Despite the…”
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Contribution of dopaminergic and adenosinergic systems in the antinociceptive effect of p-chloro-selenosteroid by Marcondes Sari, Marcel Henrique, Guerra Souza, Ana Cristina, Gonçalves Rosa, Suzan, Souza, Diego, Dorneles Rodrigues, Oscar Endrigo, Wayne Nogueira, Cristina

“…This study investigated the antinociceptive action of p-chloro-selenosteroid (PCS), administered by intragastric route (i.g.) to mice against acute models. The…”
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