Search Results - "Rodrigues, Nanda"

The Dual Specificity Phosphatases M3/6 and MKP-3 Are Highly Selective for Inactivation of Distinct Mitogen-activated Protein Kinases by Muda, Marco, Theodosiou, Aspasia, Rodrigues, Nanda, Boschert, Ursula, Camps, Montserrat, Gillieron, Corine, Davies, Kay, Ashworth, Alan, Arkinstall, Steve

“…The mitogen-activated protein (MAP) kinase family includes extracellular signal-regulated kinase (ERK), c-Jun NH2-terminal kinase/stress-activated protein…”
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A Second Promoter Provides an Alternative Target for Therapeutic up-Regulation of Utrophin in Duchenne Muscular Dystrophy by Burton, Edward A., Tinsley, Jonathon M., Holzfeind, Paul J., Rodrigues, Nanda R., Davies, Kay E.

“…Duchenne muscular dystrophy (DMD) is an inherited muscle-wasting disease caused by the absence of a muscle cytoskeletal protein, dystrophin. We have previously…”
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The Mitogen-activated Protein Kinase Phosphatase-3 N-terminal Noncatalytic Region Is Responsible for Tight Substrate Binding and Enzymatic Specificity by Muda, Marco, Theodosiou, Aspasia, Gillieron, Corine, Smith, Anna, Chabert, Christian, Camps, Montserrat, Boschert, Ursula, Rodrigues, Nanda, Davies, Kay, Ashworth, Alan, Arkinstall, Steve

“…We have reported recently that the dual specificity mitogen-activated protein kinase phosphatase-3 (MKP-3) elicits highly selective inactivation of the…”
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Genetic analysis of autoimmune type 1 diabetes mellitus in mice by Todd, John A, Aitman, Timothy J, Cornall, Richard J, Ghosh, Soumitra, Hall, Jennifer R. S, Hearne, Catherine M, Knight, Andrew M, Love, Jennifer M, McAleer, Marcia A, Prins, Jan-Bas, Rodrigues, Nanda, Lathrop, Mark, Pressey, Alison, DeLarato, Nicole H, Peterson, Laurence B, Wicker, Linda S

“…Two genes, Idd-3 and Idd-4, that influence the onset of autoimmune type 1 diabetes in the nonobese diabetic mouse have been located on chromosomes 3 and 11,…”
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Correlation of SMNt and SMNc gene copy number with age of onset and survival in spinal muscular atrophy by Taylor, J E, Thomas, N H, Lewis, C M, Abbs, S J, Rodrigues, N R, Davies, K E, Mathew, C G

“…Childhood-onset autosomal recessive spinal muscular atrophy (SMA) is associated with absence of the telomeric survival motor neuron gene (SMNt) in most…”
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Crosses of NOD mice with the related NON strain : a polygenic model for IDDM by MCALEER, M. A, REIFSNYDER, P, DELARATO, N. H, WICKER, L. S, PETERSON, L. B, SCHORK, N. J, TODD, J. A, LEITER, E. H, PALMER, S. M, PROCHAZKA, M, LOVE, J. M, COPEMAN, J. B, POWELL, E. E, RODRIGUES, N. R, PRINS, J.-B, SERREZE, D. V

“…Chromosome locations of non-major histocompatibility complex (MHC) genes contributing to insulin-dependent diabetes mellitus (IDDM) in mice have been…”
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Linkage on Chromosome 3 of Autoimmune Diabetes and Defective Fc Receptor for IgG in NOD Mice by Prins, Jan-Bas, Todd, John A., Rodrigues, Nanda R., Ghosh, Soumitra, Hogarth, P. Mark, Wicker, Linda S., Gaffney, Erin, Podolin, Patricia L., Fischer, Paul A., Sirotina, Anna, Peterson, Laurence B.

“…A congenic, non-obese diabetic (NOD) mouse strain that contains a segment of chromosome 3 from the diabetes-resistant mouse strain B6.PL-Thy-1$^a$ was less…”
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Analysis of mutations in the tudor domain of the survival motor neuron protein SMN by Mohaghegh, P, Rodrigues, N R, Owen, N, Ponting, C P, Le, T T, Burghes, A H, Davies, K E

“…Autosomal recessive childhood onset spinal muscular atrophy (SMA) is a leading cause of infant mortality caused by mutations in the survival motor neuron (SMN)…”
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Pillars Article: Genetic Analysis of Autoimmune Type 1 Diabetes Mellitus in Mice. Nature. 1991. 351: 542-547 by Todd, John A, Aitman, Timothy J, Cornall, Richard J, Ghosh, Soumitra, Hall, Jennifer RS, Hearne, Catherine M, Knight, Andrew M, Love, Jennifer M, McAleer, Marcia A, Prins, Jan-Bas, Rodrigues, Nanda, Lathrop, Mark, Pressey, Alison, DeLarato, Nicole H, Peterson, Laurence B, Wicker, Linda S

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Linkage analysis of 84 microsatellite markers in intra- and interspecific backcrosses by McAleer, M A, Aitman, T J, Cornall, R J, Ghosh, S, Hall, J R, Hearne, C M, Love, J M, Prins, J B, Ramachandran, S, Rodrigues, N

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p53 Mutations in Colorectal Cancer by Rodrigues, Nanda R., Rowan, Andrew, Mark E. F. Smith, Kerr, Ian B., Bodmer, Walter F., Gannon, Julian V., Lane, David P.

“…Immunohistological staining of primary colorectal carcinomas with antibodies specific to p53 demonstrated gross overexpression of the protein in ≈ 50% of the…”
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Genetic analysis of autoimmune type 1 diabetes mellitus in mice. 1991 by Todd, John A, Aitman, Timothy J, Cornall, Richard J, Ghosh, Soumitra, Hall, Jennifer R S, Hearne, Catherine M, Knight, Andrew M, Love, Jennifer M, McAleer, Marcia A, Prins, Jan-Bas, Rodrigues, Nanda, Lathrop, Mark, Pressey, Alison, DeLarato, Nicole H, Peterson, Laurence B, Wicker, Linda S

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Missense mutation clustering in the survival motor neuron gene : a role for a conserved tyrosine and glycine rich region of the protein in RNA metabolism? by TALBOT, K, PONTING, C. P, THEODOSIOU, A. M, RODRIGUES, N. R, SURTEES, R, MOUNTFORD, R, DAVIES, K. E

“…The Survival Motor Neuron (SMN) gene shows deletions in the majority of patients with Spinal Muscular Atrophy (SMA), a disease of motor neuron degeneration. To…”
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Reactivity of Cytosine and Thymine in Single-Base-Pair Mismatches with Hydroxylamine and Osmium Tetroxide and Its Application to the Study of Mutations by Richard G. H. Cotton, Rodrigues, Nanda R., Campbell, R. Duncan

“…The chemical reactivity of thymine (T), when mismatched with the bases cytosine, guanine, and thymine, and of cytosine (C), when mismatched with thymine,…”
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Syntenic Organization of the Mouse Distal Chromosome 7 Imprinting Cluster and the Beckwith-Wiedemann Syndrome Region in Chromosome 11p15.5 by Paulsen, Martina, Davies, Karen R., Bowden, Lucy M., Villar, Angela J., Franck, Olivia, Fuermann, Martina, Dean, Wendy L., Moore, Tom F., Rodrigues, Nanda, Davies, Kay E., Hu, Ren-J., Feinberg, Andrew P., Maher, Eamonn R., Reik, Wolf, Walter, Jörn

“…In human and mouse, most imprinted genes are arranged in chromosomal clusters. Their linked organization suggests co-ordinated mechanisms controlling…”
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Gene deletions in spinal muscular atrophy by Rodrigues, N R, Owen, N, Talbot, K, Patel, S, Muntoni, F, Ignatius, J, Dubowitz, V, Davies, K E

“…Two candidate genes (NAIP and SMN) have recently been reported for childhood onset spinal muscular atrophy (SMA). Although affected subjects show deletions of…”
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Characterization of Ngef, a Novel Member of the Dbl Family of Genes Expressed Predominantly in the Caudate Nucleus by Rodrigues, Nanda R., Theodosiou, Aspasia M., Nesbit, M.Andrew, Campbell, Louise, Tandle, Anita T., Saranath, Dhananjaya, Davies, Kay E.

“…We have identified Ngef as a novel member of the family of Dbl genes. Many members of this family have been shown to function as guanine nucleotide exchange…”
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Gene conversion at the SMN locus in autosomal recessive spinal muscular atrophy does not predict a mild phenotype by Talbot, Kevin, Rodrigues, Nanda R., Ignatius, Jaakko, Muntoni, Francesco, Davies, Kay E.

“…Autosomal recessive proximal spinal muscular atrophy (SMA) is a disease of motor neuron death and a common cause of morbidity in childhood. It has been mapped…”
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Evidence for compound heterozygosity causing mild and severe forms of autosomal recessive spinal muscular atrophy by Talbot, K, Rodrigues, N, Bernert, G, Bittner, R, Davies, K

“…Spinal muscular atrophy is an autosomal recessive disease of motor neurone degeneration which shows a variable phenotype. Two candidate genes show deletions in…”
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Molecular characterization of the HLA‐linked steroid 21‐hydroxylase B gene from an individual with congenital adrenal hyperplasia by Rodrigues, N. R., Dunham, I., Yu, C. Y., Carroll, M. C., Porter, R. R., Campbell, R. D.

“…21‐Hydroxylase deficiency which causes congenital adrenal hyperplasia is one of the most common defects of adrenal steroidogenesis. There are two…”
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