Search Results - "Rodrigues, Miguel A."

Supercritical carbon dioxide-based technologies for the production of drug nanoparticles/nanocrystals – A comprehensive review by Padrela, Luís, Rodrigues, Miguel A., Duarte, Andreia, Dias, Ana M.A., Braga, Mara E.M., de Sousa, Hermínio C.

“…Low drug bioavailability, which is mostly a result of poor aqueous drug solubilities and of inadequate drug dissolution rates, is one of the most significant…”
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Connecting high-temperature and low-temperature protein stability and aggregation by Rosa, Mónica, Roberts, Christopher J, Rodrigues, Miguel A

“…Protein aggregation is a long-standing problem for preservation of proteins in both laboratory settings and for commercial biotechnology products. It is well…”
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Enzymatic saccharification of biologically pre-treated wheat straw with white-rot fungi by Dias, Albino A., Freitas, Gil S., Marques, Guilhermina S.M., Sampaio, Ana, Fraga, Irene S., Rodrigues, Miguel A.M., Evtuguin, Dmitry V., Bezerra, Rui M.F.

“…Wheat straw was submitted to a pre-treatment by the basidiomycetous fungi Euc-1 and Irpex lacteus, aiming to improve the accessibility of cellulose towards…”
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Modification of wheat straw lignin by solid state fermentation with white-rot fungi by Dinis, Maria J., Bezerra, Rui M.F., Nunes, Fernando, Dias, Albino A., Guedes, Cristina V., Ferreira, Luís M.M., Cone, John W., Marques, Guilhermina S.M., Barros, Ana R.N., Rodrigues, Miguel A.M.

“…The potential of crude enzyme extracts, obtained from solid state cultivation of four white-rot fungi ( Trametes versicolor, Bjerkandera adusta, Ganoderma…”
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Formation of indomethacin–saccharin cocrystals using supercritical fluid technology by Padrela, Luis, Rodrigues, Miguel A., Velaga, Sitaram P., Matos, Henrique A., de Azevedo, Edmundo Gomes

“…The main objective of the present work is to check the feasibility of supercritical fluid (SCF) technologies in the screening and design of cocrystals (novel…”
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Polymorphism in Pharmaceutical Drugs by Supercritical CO2 Processing: Clarifying the Role of the Antisolvent Effect and Atomization Enhancement by Rodrigues, Miguel A, Tiago, João M, Duarte, Andreia, Geraldes, Vítor, Matos, Henrique A, Gomes Azevedo, Edmundo

“…Supercritical carbon dioxide (scCO2) induces polymorphism in pharmaceutical drugs. However, it is unclear whether polymorphism is induced by the CO2…”
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Single-Step Co-Crystallization and Lipid Dispersion by Supercritical Enhanced Atomization by Tiago, João M, Padrela, Luís, Rodrigues, Miguel A, Matos, Henrique A, Almeida, António J, Azevedo, Edmundo Gomes de

“…This work evaluates the feasibility of the supercritical enhanced atomization (SEA) process to improve stability and delivery of active pharmaceutical…”
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Influence of ligninolytic enzymes on straw saccharification during fungal pretreatment by Pinto, Paula A, Dias, Albino A, Fraga, Irene, Marques, Guilhermina, Rodrigues, Miguel A.M, Colaço, Jorge, Sampaio, Ana, Bezerra, Rui M.F

“…Solid state and submerged fermentations in the presence of white-rot basidiomycetes (Bjerkandera adusta, Fomes fomentarius, Ganoderma resinaceum, Irpex…”
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Theophylline polymorphs by atomization of supercritical antisolvent induced suspensions by Rodrigues, Miguel A., Padrela, Luis, Geraldes, Vitor, Santos, José, Matos, Henrique A., Azevedo, Edmundo Gomes

“…[Display omitted] ► We developed ASAIS: the Atomization of Supercritical Antisolvent Induced Suspensions. ► A TPL polymorph, exclusive of SC-CO 2 anti-solvent…”
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New Thermoresistant Polymorph from CO2 Recrystallization of Minocycline Hydrochloride by Rodrigues, Miguel A., Tiago, João M., Padrela, Luis, Matos, Henrique A., Nunes, Teresa G., Pinheiro, Lídia, Almeida, António J., de Azevedo, Edmundo Gomes

“…Purpose To prepare and thoroughly characterize a new polymorph of the broad-spectrum antibiotic minocycline from its hydrochloride dehydrate salts. Methods The…”
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Freezing of Biologicals Revisited: Scale, Stability, Excipients, and Degradation Stresses by Authelin, Jean-Rene, Rodrigues, Miguel A, Tchessalov, Serguei, Singh, Satish K, McCoy, Timothy, Wang, Stuart, Shalaev, Evgenyi

“…Although many biotech products are successfully stored in the frozen state, there are cases of degradation of biologicals during freeze storage. These examples…”
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Pretreatment of Grape Stalks by Fungi: Effect on Bioactive Compounds, Fiber Composition, Saccharification Kinetics and Monosaccharides Ratio by Fernandes, Joana M.C., Fraga, Irene, Sousa, Rose M.O.F., Rodrigues, Miguel A.M., Sampaio, Ana, Bezerra, Rui M.F., Dias, Albino A.

“…Grape stalks, an inedible lignocellulosic residue from winemaking and agro-industrial grape juice production, can be valorized as a source of bioactive…”
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Cryoconcentration and 3D Temperature Profiles During Freezing of mAb Solutions in Large-Scale PET Bottles and a Novel Scale-Down Device by Bluemel, Oliver, Buecheler, Jakob W., Rodrigues, Miguel A., Geraldes, Vitor, Hoelzl, Georg, Bechtold-Peters, Karoline, Friess, Wolfgang

“…Purpose Small-scale models that simulate large-scale freezing of bulk drug substance of biopharmaceuticals are highly needed to define freezing and formulation…”
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Computational fluid dynamic simulations of temperature, cryoconcentration, and stress time during large-scale freezing and thawing of monoclonal antibody solutions by Bluemel, Oliver, Pavlišič, Andraž, Likozar, Blaž, Rodrigues, Miguel A., Geraldes, Vitor, Bechtold-Peters, Karoline, Friess, Wolfgang

“…[Display omitted] Large-scale freezing and thawing experiments of monoclonal antibody (mAb) solutions are time and material consuming. Computational Fluid…”
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Native and Non-Native aggregation pathways of antibodies anticipated by cold-accelerated studies by Rodrigues, Miguel A., Duarte, Andreia, Geraldes, Vitor, Kingsbury, Jonathan S., Sanket, Patke, Filipe, Vasco, Nakach, Mostafa, Authelin, Jean-Rene

“…Assessment of cold stability is essential for manufacture and commercialization of biotherapeutics. Storage stability is often estimated by measuring…”
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Freeze-Induced Phase Transition and Local Pressure in a Phospholipid/Water System: Novel Insights Were Obtained from a Time/Temperature Resolved Synchrotron X‑ray Diffraction Study by Rodrigues, Miguel A., Matsarskaia, Olga, Rego, Pedro, Geraldes, Vitor, Connor, Lauren E., Oswald, Iain D. H., Sztucki, Michael, Shalaev, Evgenyi

“…Water-to-ice transformation results in a 10% increase in volume, which can have a significant impact on biopharmaceuticals during freeze–thaw cycles due to the…”
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Interfacial Stress and Container Failure During Freezing of Bulk Protein Solutions Can Be Prevented by Local Heating by Duarte, Andreia, Rego, Pedro, Ferreira, Aida, Dias, Paulo, Geraldes, Vítor, Rodrigues, Miguel A.

“…Bottles and carboys are used for frozen storage and transport of biopharmaceutical formulations under a wide range of conditions. The quality of freezing and…”
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Stability of Protein Formulations at Subzero Temperatures by Isochoric Cooling by Correia, Cátia, Tavares, Evandro, Lopes, Carlos, Silva, Joana G, Duarte, Andreia, Geraldes, Vitor, Rodrigues, Miguel A, Melo, Eduardo P

“…Optimization of protein formulations at subzero temperatures is required for many applications such as storage, transport, and lyophilization. Using isochoric…”
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Mannitol Crystallization at Sub-Zero Temperatures: Time/Temperature-Resolved Synchrotron X‑ray Diffraction Study and the Phase Diagram by Rodrigues, Miguel A, Rego, Pedro, Geraldes, Vitor, Connor, Lauren E, Oswald, Iain D. H, Sztucki, Michael, Shalaev, Evgenyi

“…Mannitol, a common pharmaceutical ingredient, exhibits complex polymorphism even in simple binary mannitol/water mixtures, with four crystalline forms…”
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Evaluation of the nutritive value of muiumba (Baikiaea plurijuga) seeds: chemical composition, in vitro organic matter digestibility and in vitro gas production by Rodrigues, Miguel A M, Lourenço, Ana L, Cone, John W, Nunes, Fernando M, Santos, Ana S, Cordeiro, José M M, Guedes, Cristina M V, Ferreira, Luis M M

“…One of the main constraints hindering the increase of animal production in semi-arid regions of Africa is the inadequate supply of nutrients during the dry…”
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