Search Results - "Rodrigues, M.P."

miR-34a/SIRT1/p53 is suppressed by ursodeoxycholic acid in the rat liver and activated by disease severity in human non-alcoholic fatty liver disease by Castro, Rui E, Ferreira, Duarte M.S, Afonso, Marta B, Borralho, Pedro M, Machado, Mariana V, Cortez-Pinto, Helena, Rodrigues, Cecília M.P

“…Background & Aims Non-alcoholic fatty liver disease (NAFLD) comprises a spectrum of stages from simple steatosis to non-alcoholic steatohepatitis (NASH)…”
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Necroptosis is a key pathogenic event in human and experimental murine models of non-alcoholic steatohepatitis by Afonso, Marta B, Rodrigues, Pedro M, Carvalho, Tânia, Caridade, Marta, Borralho, Paula, Cortez-Pinto, Helena, Castro, Rui E, Rodrigues, Cecília M P

“…Hepatocyte cell death, inflammation and oxidative stress constitute key pathogenic mechanisms underlying non-alcoholic fatty liver disease (NAFLD). We aimed to…”
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Bile acids: regulation of apoptosis by ursodeoxycholic acid by Amaral, Joana D., Viana, Ricardo J.S., Ramalho, Rita M., Steer, Clifford J., Rodrigues, Cecília M.P.

“…Bile acids are a group of molecular species of acidic steroids with peculiar physical-chemical and biological characteristics. At high concentrations they…”
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Mechanical properties, shrinkage stress, cuspal strain and fracture resistance of molars restored with bulk-fill composites and incremental filling technique by Rosatto, C.M.P, Bicalho, A.A, Veríssimo, C, Bragança, G.F, Rodrigues, M.P, Tantbirojn, D, Versluis, A, Soares, C.J

“…Abstract Objectives To compare bulk-fill with incremental filling techniques for restoring large mesio-occlusal-distal (MOD) restorations. Methods Seventy-five…”
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Lytic cell death in metabolic liver disease by Gautheron, Jérémie, Gores, Gregory J., Rodrigues, Cecília M.P.

“…Regulated cell death is intrinsically associated with inflammatory liver disease and is pivotal in governing outcomes of metabolic liver disease. Different…”
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Tauroursodeoxycholic acid (TUDCA) supplementation prevents cognitive impairment and amyloid deposition in APP/PS1 mice by Lo, Adrian C, Callaerts-Vegh, Zsuzsanna, Nunes, Ana F, Rodrigues, Cecília M.P, D'Hooge, Rudi

“…Abstract Alzheimer's disease (AD) is a neurodegenerative disease hallmarked by extracellular Aβ1–42 containing plaques, and intracellular neurofibrillary…”
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Monoterpene bisindole alkaloids, from the African medicinal plant Tabernaemontana elegans, induce apoptosis in HCT116 human colon carcinoma cells by Mansoor, Tayyab A., Borralho, Pedro M., Dewanjee, Saikat, Mulhovo, Silva, Rodrigues, Cecília M.P., Ferreira, Maria-José U.

“…Tabernaemontana elegans is a medicinal plant used in African traditional medicine to treat several ailments including cancer. The aims of the present study…”
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Delivering the promise of miRNA cancer therapeutics by Pereira, Diane M., Rodrigues, Pedro M., Borralho, Pedro M., Rodrigues, Cecília M.P.

“…► Delivery strategies for miRNA modulators (miRNA mimics/inhibitors) in cancer. ► Local versus systemic delivery in vivo. ► Modified miRNA modulators. ►…”
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p53 Is a Key Molecular Target of Ursodeoxycholic Acid in Regulating Apoptosis by Amaral, Joana D., Castro, Rui E., Solá, Susana, Steer, Clifford J., Rodrigues, CecÁlia M.P.

“…p53 plays an important role in regulating expression of genes that mediate cell cycle progression and/or apoptosis. In addition, we have previously shown that…”
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Inhibition of receptor-interacting protein kinase 1 improves experimental non-alcoholic fatty liver disease by Majdi, Amine, Aoudjehane, Lynda, Ratziu, Vlad, Islam, Tawhidul, Afonso, Marta B., Conti, Filomena, Mestiri, Taïeb, Lagouge, Marie, Foufelle, Fabienne, Ballenghien, Florine, Ledent, Tatiana, Moldes, Marthe, Cadoret, Axelle, Fouassier, Laura, Delaunay, Jean-Louis, Aït-Slimane, Tounsia, Courtois, Gilles, Fève, Bruno, Scatton, Olivier, Prip-Buus, Carina, Rodrigues, Cecília M.P., Housset, Chantal, Gautheron, Jérémie

“…In non-alcoholic fatty liver disease (NAFLD), hepatocytes can undergo necroptosis: a regulated form of necrotic cell death mediated by the receptor-interacting…”
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Targeting the p53 pathway of apoptosis by Amaral, Joana D, Xavier, Joana M, Steer, Clifford J, Rodrigues, Cecília M P

“…The tumor suppressor protein, p53 is regarded as a key player in tumor suppression, as it promotes growth arrest, apoptosis and cellular senescence, while also…”
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Bile acids and apoptosis modulation: an emerging role in experimental Alzheimer's disease by Ramalho, Rita M, Viana, Ricardo J.S, Low, Walter C, Steer, Clifford J, Rodrigues, Cecília M.P

“…The potential role of apoptosis in Alzheimer's disease (AD) has been an area of intense research in recent years. Ursodeoxycholic acid (UDCA) and its…”
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Effect of pulp-capping and filling-technique on pulp-chamber heating and deformation by Soares, C.J, Ferreira, M.S, Rodrigues, M.P, Braga, S.S.L, Soares, P.B.F, Schliebe, L.R.S.O, Bicalho, A.A

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OPTIMIZATION OF THE GENERAL SURGERY SERVICE OF THE UNIVERSITY HOSPITAL PEDRO ERNESTO by Cunha, G.N, Vianna, C.M, Oliveira, F.S, Mosegui, G.B, Assumpcao, L.R, Rodrigues, M.P

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Caspases and p53 modulate FOXO3A/Id1 signaling during mouse neural stem cell differentiation by Aranha, Márcia M., Solá, Susana, Low, Walter C., Steer, Clifford J., Rodrigues, Cecília M.P.

“…Neural stem cells (NSCs) differentiate into neurons and glia, and a large percentage undergoes apoptosis. The engagement and activity of apoptotic pathways may…”
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Impaired cross-talk between the thioredoxin and glutathione systems is related to ASK-1 mediated apoptosis in neuronal cells exposed to mercury by Branco, Vasco, Coppo, Lucia, Solá, Susana, Lu, Jun, Rodrigues, Cecília M.P., Holmgren, Arne, Carvalho, Cristina

“…Mercury (Hg) compounds target both cysteine (Cys) and selenocysteine (Sec) residues in peptides and proteins. Thus, the components of the two major cellular…”
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Preclinical validation of a new hybrid molecule loaded in liposomes for melanoma management by Pinho, Jacinta O., Matias, Mariana, Marques, Vanda, Eleutério, Carla, Fernandes, Célia, Gano, Lurdes, Amaral, Joana D., Mendes, Eduarda, Perry, Maria Jesus, Moreira, João Nuno, Storm, Gert, Francisco, Ana Paula, Rodrigues, Cecília M.P., Gaspar, M. Manuela

“…The aggressiveness of melanoma and lack of effective therapies incite the discovery of novel strategies. Recently, a new dual acting hybrid molecule (HM),…”
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Synthesis and evaluation of spiroisoxazoline oxindoles as anticancer agents by Ribeiro, Carlos J.A., Amaral, Joana D., Rodrigues, Cecília M.P., Moreira, Rui, Santos, Maria M.M.

“…We herein report the synthesis and evaluation of eighteen spiroisoxazoline oxindoles derivatives as p53–MDM2 interaction inhibitors. Seven compounds showed an…”
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Deoxycholic acid modulates cell death signaling through changes in mitochondrial membrane properties[S] by Sousa, Tânia, Castro, Rui E., Pinto, Sandra N., Coutinho, Ana, Lucas, Susana D., Moreira, Rui, Rodrigues, Cecília M.P., Prieto, Manuel, Fernandes, Fábio

“…Cytotoxic bile acids, such as deoxycholic acid (DCA), are responsible for hepatocyte cell death during intrahepatic cholestasis. The mechanisms responsible for…”
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Cell death targets and potential modulators in Alzheimer's disease by Castro, Rui E, Santos, Maria M M, Glória, Paulo M C, Ribeiro, Carlos J A, Ferreira, Duarte M S, Xavier, Joana M, Moreira, Rui, Rodrigues, Cecília M P

“…Apoptosis is now recognized as a normal feature in the development of the nervous system and may also play a role in neurodegenerative disorders, such as…”
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