Analysis of FokI polymorphism of vitamin D receptor gene in intervertebral disc degeneration

We have hypothesized a possible relationship between disc degeneration (DD) and VDR FokI/T2C polymorphism. A case-control study was performed comprising 121 Brazilian patients with confirmed DD by nuclear magnetic resonance and a control group consisting of 131 healthy patients without a history of...

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Bibliographic Details
Published in:	Genetic testing and molecular biomarkers Vol. 18; no. 9; p. 625
Main Authors:	Vieira, Luiz Angelo, De Marchi, Patricia Leme, dos Santos, Aline Amaro, Christofolini, Denise Maria, Barbosa, Caio Parente, Fonseca, Fernando Luiz Affonso, Bianco, Bianca, Rodrigues, Luciano Miller R
Format:	Journal Article
Language:	English
Published:	United States 01-09-2014
Subjects:	Adult Alleles Brazil Deoxyribonucleases, Type II Site-Specific Female Gene Frequency Humans Intervertebral Disc Degeneration - diagnostic imaging Intervertebral Disc Degeneration - genetics Magnetic Resonance Imaging Male Middle Aged Polymerase Chain Reaction Prospective Studies Radiography Receptors, Calcitriol - genetics
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Summary:	We have hypothesized a possible relationship between disc degeneration (DD) and VDR FokI/T2C polymorphism. A case-control study was performed comprising 121 Brazilian patients with confirmed DD by nuclear magnetic resonance and a control group consisting of 131 healthy patients without a history of disc cysts of the lumbar spine. Detection of VDR FokI/T2C polymorphism was performed using restriction fragment length polymorphism-polymerase chain reaction. The chi-square test was used to compare allele and genotype frequencies between groups, and a p-value of <0.05 was considered statistically significant. The results disclosed statistical difference between allele distribution among cases and controls (p=0.025, odds ratio=1.58, confidence interval=1.07-2.32) considering VDR FokI/T2C polymorphism. The results showed a positive association between VDR FokI/T2C polymorphism and DD in Brazilian patients tested.
ISSN:	1945-0257
DOI:	10.1089/gtmb.2014.0030