Search Results - "Rodrigues, Lais S"

Does Parkinson's disease and type-2 diabetes mellitus present common pathophysiological mechanisms and treatments? by Lima, Marcelo M S, Targa, Adriano D S, Noseda, Ana C D, Rodrigues, Lais S, Delattre, Ana Marcia, dos Santos, Fabiola V, Fortes, Mariana H, Maturana, Maira J, Ferraz, Anete C

“…Parkinson's disease (PD) is the second most common neurodegenerative disease afflicting about 1% of people over 65 years old and 4-5% of people over 85 years…”
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Absence of a synergic nigral proapoptotic effect triggered by REM sleep deprivation in the rotenone model of Parkinson´s disease by Kmita, Luana C, Ilkiw, Jessica L, Rodrigues, Lais S, Targa, Adriano DS, Noseda, Ana Carolina D, dos-Santos, Patrícia, Fagotti, Juliane, Trindade, Edvaldo S., Lima, Marcelo MS

“…Excitotoxicity has been related to play a crucial role in Parkinson's disease (PD) pathogenesis. Pedunculopontine tegmental nucleus (PPT) represents one of the…”
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Olfactory impairment is related to REM sleep deprivation in rotenone model of Parkinson's disease by Aurich, Mariana F., Rodrigues, Lais S., Targa, Adriano D. S., Noseda, Ana Carolina D., Cunha, Flávia D. W., Lima, Marcelo M. S.

“…Abstract Introduction Olfactory dysfunction affects about 85-90% of Parkinson's disease (PD) patients with severe deterioration in the ability of discriminate…”
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Disruption of neocortical synchronisation during slow‐wave sleep in the rotenone model of Parkinson’s disease by Santos Lima, Gustavo Zampier, Targa, Adriano D. S., Freitas Cavalcante, Samantha, Rodrigues, Lais S., Fontenele‐Araújo, John, Torterolo, Pablo, Andersen, Monica L., Lima, Marcelo M. S.

“…Parkinson’s disease motor dysfunctions are associated with improperly organised neural oscillatory activity. The presence of such disruption at the early…”
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MT2 melatonin receptors expressed in the olfactory bulb modulate depressive-like behavior and olfaction in the 6-OHDA model of Parkinson's disease by Noseda, Ana Carolina D., Rodrigues, Lais S., Targa, Adriano D.S., Ilkiw, Jessica L., Fagotti, Juliane, dos Santos, Patricia D., Cecon, Erika, Markus, Regina P., Solimena, Michele, Jockers, Ralf, Lima, Marcelo M.S.

“…Melatonin MT1 and MT2 receptors are expressed in the glomerular layer of the olfactory bulb (OB); however, the role of these receptors has not been evaluated…”
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Dopaminergic Lesion in the Olfactory Bulb Restores Olfaction and Induces Depressive-Like Behaviors in a 6-OHDA Model of Parkinson’s Disease by Ilkiw, Jessica L., Kmita, Luana C., Targa, Adriano D. S., Noseda, Ana Carolina D., Rodrigues, Lais S., Dorieux, Flávia W. C., Fagotti, Juliane, dos Santos, Patrícia, Lima, Marcelo M. S.

“…Olfactory impairments and depressive behavior are commonly reported by individuals with Parkinson’s disease (PD) being observed before motor symptoms. The…”
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Comparative analysis of uninduced and neuronally-induced human dental pulp stromal cells in a 6-OHDA model of Parkinson's disease by Azevedo, Evellyn M., Fracaro, Letícia, Hochuli, Agner H.D., Ilkiw, Jéssica, Bail, Ellen L., Lisboa, Mateus de O., Rodrigues, Lais S., Barchiki, Fabiane, Correa, Alejandro, Capriglione, Luiz G.A., Brofman, Paulo R.S., Lima, Marcelo M.S.

“…•Uninduced and neuronally-induced DPSCs demonstrate potential for Parkinson's disease therapy.•Uninduced and neuronally-induced DPSCs promote significant…”
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REM sleep deprivation and dopaminergic D2 receptors modulation increase recognition memory in an animal model of Parkinson’s disease by Targa, Adriano D.S., Noseda, Ana Carolina D., Rodrigues, Lais S., Aurich, Mariana F., Lima, Marcelo M.S.

“…•D2 receptors blockade, SNpc and PPT lesion impaired object recognition memory.•REMSD prevented/reversed the deleterious effects induced by these…”
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Chronic sleep restriction in the rotenone Parkinson’s disease model in rats reveals peripheral early-phase biomarkers by Fagotti, Juliane, Targa, Adriano D. S., Rodrigues, Lais S., Noseda, Ana Carolina D., Dorieux, Flávia W. C., Scarante, Franciele F., Ilkiw, Jessica L., Louzada, Fernando M., Chowdhury, Namrata R., van der Veen, Daan R., Middleton, Benita, Pennings, Jeroen L. A., Swann, Jonathan R., Skene, Debra J., Lima, Marcelo M. S.

“…Parkinson’s disease (PD) is a chronic disorder that presents a range of premotor signs, such as sleep disturbances and cognitive decline, which are key…”
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Folic Acid and Vitamin B12 Prevent Deleterious Effects of Rotenone on Object Novelty Recognition Memory and Kynu Expression in an Animal Model of Parkinson's Disease by Kretzschmar, Gabriela Canalli, Targa, Adriano D S, Soares-Lima, Sheila Coelho, Dos Santos, Priscila Ianzen, Rodrigues, Lais S, Macedo, Daniel A, Ribeiro Pinto, Luis Felipe, Lima, Marcelo M S, Boldt, Angelica Beate Winter

“…Parkinson's disease (PD) is characterized by a range of motor signs, but cognitive dysfunction is also observed. Supplementation with folic acid and vitamin…”
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Unraveling a new circuitry for sleep regulation in Parkinson's disease by Targa, Adriano D.S., Rodrigues, Lais S., Noseda, Ana Carolina D., Aurich, Mariana F., Andersen, Monica L., Tufik, Sergio, da Cunha, Cláudio, Lima, Marcelo M.S.

“…Sleep disturbances are among the most disabling non-motor symptoms in Parkinson's disease. The pedunculopontine tegmental nucleus and basal ganglia are likely…”
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Potential new therapies against a toxic relationship: neuroinflammation and Parkinson’s disease by Rodrigues, Lais S, Fagotti, Juliane, D.S. Targa, Adriano, D. Noseda, Ana Carolina, L. Ilkiwa, Jéssica, Chuproski, Ana Paula, W.C. Dorieux, Flavia, D. dos Santos, Patricia, M.S. Lima, Marcelo

“…Parkinson’s disease (PD) is a neurodegenerative disorder classically associated with motor symptoms, but several nonmotor disturbances appear decades before…”
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Olfaction in female Wistar rats is influenced by dopaminergic periglomerular neurons after nigral and bulbar lesions by Rodrigues, Lais S, Noseda, Ana C.D, Targa, Adriano D.S, Aurich, Mariana F, Lima, Marcelo M.S

“…Hyposmia is found in Parkinsonian patients decades before the onset of motor disorders. The same occurs with sleep disorders, especially infuencing rapid eye…”
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Cholinergic Oculomotor Nucleus Activity Is Induced by REM Sleep Deprivation Negatively Impacting on Cognition by Santos, Patrícia Dos, Targa, Adriano D. S., Noseda, Ana Carolina D., Rodrigues, Lais S., Fagotti, Juliane, Lima, Marcelo M. S.

“…Several efforts have been made to understand the involvement of rapid eye movement (REM) sleep for cognitive processes. Consolidation or retention of…”
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REM Sleep Deprivation Reverses Neurochemical and Other Depressive-Like Alterations Induced by Olfactory Bulbectomy by Maturana, Maira J., Pudell, Cláudia, Targa, Adriano D. S., Rodrigues, Laís S., Noseda, Ana Carolina D., Fortes, Mariana H., dos Santos, Patrícia, Da Cunha, Cláudio, Zanata, Sílvio M., Ferraz, Anete C., Lima, Marcelo M. S.

“…There is compelling evidence that sleep deprivation (SD) is an effective strategy in promoting antidepressant effects in humans, whereas few studies were…”
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Putative role of monoamines in the antidepressant-like mechanism induced by striatal MT2 blockade by Noseda, Ana Carolina D., Rodrigues, Lais S., Targa, Adriano D.S., Aurich, Mariana F., Vital, Maria A.B.F., Da Cunha, Cláudio, Lima, Marcelo M.S.

“…•Antidepressant effects triggered by MT2 blockade in the striatum.•Association of striatal MT2 blockade and REMSD generates decreases 5-HT.•4-P-PDOT increased…”
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Olfactory impairment in the rotenone model of Parkinson's disease is associated with bulbar dopaminergic D2 activity after REM sleep deprivation by Rodrigues, Lais S, Targa, Adriano D S, Noseda, Ana Carolina D, Aurich, Mariana F, Da Cunha, Cláudio, Lima, Marcelo M S

“…Olfactory and rapid eye movement (REM) sleep deficits are commonly found in untreated subjects with a recent diagnosis of Parkinson's disease (PD)…”
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REM sleep deprivation promotes a dopaminergic influence in the striatal MT2 anxiolytic-like effects by Noseda, Ana Carolina D., Targa, Adriano D.S., Rodrigues, Lais S., Aurich, Mariana F., Lima, Marcelo M.S.

“…The aim of this study was to investigate the possible anxiolytic-like effects of striatal MT2 activation, and its counteraction induced by the selective…”
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Folic Acid and Vitamin B12 Prevent Deleterious Effects of Rotenone on Object Novelty Recognition Memory and IKynu/I Expression in an Animal Model of Parkinson’s Disease by Kretzschmar, Gabriela Canalli, Targa, Adriano D. S, Soares-Lima, Sheila Coelho, dos Santos, Priscila Ianzen, Rodrigues, Lais S, Macedo, Daniel A, Ribeiro Pinto, Luis Felipe, Lima, Marcelo M. S, Boldt, Angelica Beate Winter

“…Parkinson’s disease (PD) is characterized by a range of motor signs, but cognitive dysfunction is also observed. Supplementation with folic acid and vitamin…”
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MT 2 melatonin receptors expressed in the olfactory bulb modulate depressive-like behavior and olfaction in the 6-OHDA model of Parkinson's disease by Noseda, Ana Carolina D, Rodrigues, Lais S, Targa, Adriano D S, Ilkiw, Jessica L, Fagotti, Juliane, Dos Santos, Patricia D, Cecon, Erika, Markus, Regina P, Solimena, Michele, Jockers, Ralf, Lima, Marcelo M S

“…Melatonin MT and MT receptors are expressed in the glomerular layer of the olfactory bulb (OB); however, the role of these receptors has not been evaluated…”
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