Search Results - "Rodrigues, Debora G"

Use of cholesterol-rich nanoparticles that bind to lipoprotein receptors as a vehicle to paclitaxel in the treatment of breast cancer: pharmacokinetics, tumor uptake and a pilot clinical study by Pires, Luís A., Hegg, Roberto, Valduga, Claudete J., Graziani, Sílvia R., Rodrigues, Débora G., Maranhão, Raul C.

“…Purpose In animal experiments paclitaxel oleate associated with a cholesterol-rich nanoemulsion concentrated in the neoplastic tissues and showed reduced…”
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Comparative pharmacokinetic and pharmacodynamic evaluation between a new biosimilar and reference recombinant human growth hormone by Toffoletto, Odaly, Afiune, Jorge, Thiemann, Josef Ernst, Khandave, Suhas S, Patel, Swati, Rodrigues, Debora G

“…Abstract Objective To extend available dosing options in the treatment of growth hormone deficiency, a comparative pharmacokinetic and pharmacodynamic phase-1…”
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Paclitaxel associated with cholesterol-rich nanoemulsions promotes atherosclerosis regression in the rabbit by Maranhão, Raul C, Tavares, Elaine R, Padoveze, Amanda F, Valduga, Claudete J, Rodrigues, Debora G, Pereira, Maria D

“…Abstract A cholesterol-rich nanoemulsion (LDE) that resembles LDL binds to the LDL receptors and after injection into the blood stream may concentrate in cells…”
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Pharmacokinetics and tumor uptake of a derivatized form of paclitaxel associated to a cholesterol-rich nanoemulsion (LDE) in patients with gynecologic cancers by DIAS, Maria L. N, CARVALHO, Jesus P, RODRIGUES, Debora G, GRAZIANI, Silvia R, MARANHAO, Raul C

“…A cholesterol-rich nanoemulsion termed LDE concentrates in cancer tissues after injection into the bloodstream. The association of a derivatized paclitaxel to…”
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Improvement of paclitaxel therapeutic index by derivatization and association to a cholesterol-rich microemulsion : in vitro and in vivo studies by RODRIGUES, Debora G, MARIA, Durvanei A, FERNANDES, Denise C, VALDUGA, Claudete J, COUTO, Ricardo D, IBANEZ, Olga C. M, MARANHAO, Raul C

“…A cholesterol-rich microemulsion or nanoparticle termed LDE concentrates in cancer tissues after injection into the bloodstream. Here the cytotoxicity,…”
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Brazil: An emerging partner in drug R&D by Rodrigues, Debora G

“…With the need for innovation in drug discovery and development and changes to patent laws that are enabling greater IP protection, many pharmaceutical…”
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Evaluation in melanoma-bearing mice of an etoposide derivative associated to a cholesterol-rich nanoemulsion by Prete, Ana C. Lo, Maria, Durvanei A., Rodrigues, Dé bora G., Valduga, Claudete J., Ibañez, Olga C. M., Maranhão, Raul C.

“…A cholesterol‐rich nanoemulsion (LDE) may be used as a vehicle to target antineoplastic drugs against cancer cells. The association of an etoposide derivative…”
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Metabolism of a cholesterol-rich microemulsion (LDE) in patients with multiple myeloma and a preliminary clinical study of LDE as a drug vehicle for the treatment of the disease by HUNGRIA, Vania T. M, LATRILHA, Maria C, RODRIGUES, Debora G, BYDLOWSKI, Sergio P, CHIATTONE, Carlos S, MARANHAO, Raul C

“…Previously we have shown that cholesterol-rich microemulsions that bind to LDL receptors have the ability to concentrate in acute myeloid leukemia cells and in…”
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Use of a cholesterol-rich microemulsion that binds to low-density lipoprotein receptors as vehicle for etoposide by Valduga, Claudete J., Fernandes, Denise C., Prete, Ana C. Lo, Azevedo, Carolina H. M., Rodrigues, Debora G., Maranhão, Raul C.

“…ABSTRACT A cholesterol‐rich microemulsion (LDE) that binds to low‐density lipoprotein (LDL) receptors is selectively taken up by malignant cells that…”
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Association of carmustine with a lipid emulsion: in vitro, in vivo and preliminary studies in cancer patients by MARANHAO, Raul C, GRAZIANI, Silvia R, YAMAGUCHI, Nise, MELO, Roberto F, LATRILHA, Maria C, RODRIGUES, Debora G, COUTO, Ricardo D, SCHREIER, Shirley, BUZAID, Antonio C

“…We had previously shown in acute leukemia and in breast and ovary carcinoma patients that a cholesterol-rich emulsion (LDE) that binds to receptors for…”
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Mpox outbreak in Rio de Janeiro, Brazil: A translational approach by Lira, Guilherme S., Ota, Victor A., Melo, Mariana Q. S., Castiñeiras, Anna C. P., Leitão, Isabela C., Silva, Bianca O., Mariani, Diana, Gonçalves, Cássia C. A., Ribeiro, Liane J., Halpern, Marcia, Abreu, Thalita F., Carneiro, Fabiana A., Scheid, Helena T., Souza, Leonardo A. V., Rodrigues, Débora G. M., Cruz, Nádia V. G., Cony, Andrea, Carvalho, Silvia, Lima, Loyze P. O., Viala, Vincent L., Caldas, Lucio A., Souza, Wanderley, Higa, Luiza M., Voloch, Carolina M., Ferreira, Orlando C., Damaso, Clarissa R., Galliez, Rafael M., Faffe, Débora S., Tanuri, Amilcar, Castiñeiras, Terezinha M. P. P.

“…Mpox is a zoonotic disease historically reported in Africa. Since 2003, limited outbreaks have occurred outside Africa. In 2022, the global spread of cases…”
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Use of a cholesterol-rich emulsion that binds to low-density lipoprotein receptors as a vehicle for paclitaxel by Rodrigues, Debora G., Covolan, Cristiane C., Coradi, Silvana T., Barboza, Renato, Maranhão, Raul C.

“…A cholesterol‐rich emulsion (LDE) is taken up by malignant cells which over‐express low‐density lipoprotein (LDL) receptors and thus may be used as a carrier…”
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Metabolism of a cholesterol-rich microemulsion (LDE) in patients with multiple myeloma and a preliminary clinical study of LDE as a drug vehicle for the treatment of the disease by Hungria Vania T M, Latrilha, Maria C, Rodrigues, Debora G, Bydlowski, Sergio P, Chiattone, Carlos S, Maranhão, Raul C

“…Purpose: Previously we have shown that cholesterol-rich microemulsions that bind to LDL receptors have the ability to concentrate in acute myeloid leukemia…”
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Evaluation in melanoma-bearing mice of an etoposide derivative associated to a cholesterol-rich nano-emulsion by Lo Prete, Ana C, Maria, Durvanei A, Rodrigues, Débora G, Valduga, Claudete J, Ibañez, Olga C M, Maranhão, Raul C

“…A cholesterol-rich nano-emulsion (LDE) may be used as a vehicle to target antineoplastic drugs against cancer cells. The association of an etoposide derivative…”
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