Search Results - "Rodrigues, Daniel A"

Duvelisib: A 2018 Novel FDA-Approved Small Molecule Inhibiting Phosphoinositide 3-Kinases by Rodrigues, Daniel A, Sagrillo, Fernanda S, Fraga, Carlos A M

“…Duvelisib (Copiktra ) is a dual inhibitor of phosphoinositide 3-kinases (PI3Kδ and PI3Kγ). In 2018, duvelisib was first approved by the Food and Drug…”
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Ru(II) Compounds: Next-Generation Anticancer Metallotherapeutics? by Thota, Sreekanth, Rodrigues, Daniel A, Crans, Debbie C, Barreiro, Eliezer J

“…Metal based therapeutics are a precious class of drugs in oncology research that include examples of theranostic drugs, which are active in both diagnostic,…”
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Beyond the Selective Inhibition of Histone Deacetylase 6 by Rodrigues, Daniel A, Thota, Sreekanth, Fraga, Carlos A M

“…Histone deacetylase 6 (HDAC6) catalyses the removal of acetyl groups from the lysine residues of a series of non-histone proteins, e.g., α-tubulin, Hsp90 and…”
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Fault diagnosis of electric submersible pumps using vibration signals by Rodrigues, Daniel A., Martins, Geniffer S. O., David, Eduardo R., Reis, Felipe L. M., Carneiro, Luiz E. M., Correia, Juliana R., Lima, Larissa M., Silva Freire, Atila P.

“…The present work assesses the feasibility of using vibration signals to establish correlations between different types of faults (a state) and related failure…”
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N-Acylhydrazones as drugs by Thota, Sreekanth, Rodrigues, Daniel A., Pinheiro, Pedro de Sena Murteira, Lima, Lídia M., Fraga, Carlos A.M., Barreiro, Eliezer J.

“…[Display omitted] •N-Acylhydrazone (NAH) motif in Drug Design and Medicinal Chemistry.•NAH-related approved drugs.•N-Acylhydrazone motif scaffolds in clinical…”
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Histone deacetylases as targets for the treatment of neurodegenerative disorders: Challenges and future opportunities by Rodrigues, Daniel A., Pinheiro, Pedro de S. M., Sagrillo, Fernanda S., Bolognesi, Maria L., Fraga, Carlos A. M.

“…Despite the applicability of histone deacetylase inhibitors (HDACis) for cancer treatment, several works in the literature have shown that these inhibitors can…”
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Occurrence and potential ecological risks of PFAS in Pampulha Lake, Brazil, a UNESCO world heritage site by V.M. Starling, Maria Clara, Rodrigues, Daniel A.S., Miranda, Gisele A., Jo, Suna, Amorim, Camila C., Ankley, Gerald T., Simcik, Matt

“…Per- and polyfluoroalkyl substances (PFAS) comprise >4000 synthetic substances used in industrial applications and consumer products. PFAS used daily in…”
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Multitarget Inhibition of Histone Deacetylase (HDAC) and Phosphatidylinositol‐3‐kinase (PI3K): Current and Future Prospects by Rodrigues, Daniel A., Pinheiro, Pedro S. M., Fraga, Carlos A. M.

“…The discovery of histone deacetylase (HDAC) inhibitors is a hot topic in the medicinal chemistry community regarding cancer research. This is related primarily…”
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Design, Synthesis, and Pharmacological Evaluation of Novel N‑Acylhydrazone Derivatives as Potent Histone Deacetylase 6/8 Dual Inhibitors by Rodrigues, Daniel A, Ferreira-Silva, Guilherme À, Ferreira, Ana C. S, Fernandes, Renan A, Kwee, Jolie K, Sant’Anna, Carlos M. R, Ionta, Marisa, Fraga, Carlos A. M

“…This manuscript describes a novel class of N-acylhydrazone (NAH) derivatives that act as histone deacetylase (HDAC) 6/8 dual inhibitors and were designed from…”
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Click-Capable Phenanthriplatin Derivatives as Tools to Study Pt(II)-Induced Nucleolar Stress by O’Dowd, Paul D., Guerrero, Andres S., Alley, Katelyn R., Pigg, Hannah C., O’Neill, Fiona, Meiller, Justine, Hobbs, Chloe, Rodrigues, Daniel A., Twamley, Brendan, O’Sullivan, Finbarr, DeRose, Victoria J., Griffith, Darren M.

“…It is well established that oxaliplatin, one of the three Pt­(II) anticancer drugs approved worldwide, and phenanthriplatin, an important preclinical…”
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Design, Synthesis, and Pharmacological Evaluation of First‐in‐Class Multitarget N‐Acylhydrazone Derivatives as Selective HDAC6/8 and PI3Kα Inhibitors by Rodrigues, Daniel A., Guerra, Fabiana S., Sagrillo, Fernanda S., Sena M. Pinheiro, Pedro, Alves, Marina A., Thota, Sreekanth, Chaves, Lorrane S., Sant'Anna, Carlos M. R., Fernandes, Patrícia D., Fraga, Carlos A. M.

“…Targeting histone deacetylases (HDACs) and phosphatidylinositol 3‐kinases (PI3Ks) is a very promising approach for cancer treatment. This manuscript describes…”
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Determination of rare earth elements in Fe-minerals using external calibration by LA-ICP-MS and application on Cauê Iron Formation (Brazil) by Sousa, Denise V.M., Abreu, Adriana T., Sampaio, Geraldo M.S., Lana, Cristiano C., Rodrigues, Daniel A.S., Nalini, Hermínio A.

“…The rare earth elements (REE) composition in Fe-mineral phases is an important tool in iron formation studies to obtain information about parent rocks and…”
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Histone Deacetylase 6 Inhibition Exploits Selective Metabolic Vulnerabilities in LKB1 Mutant, KRAS Driven NSCLC by Zhang, Hua, Nabel, Christopher S, Li, Dezhi, O'Connor, Ruth Í, Crosby, Caroline R, Chang, Sarah M, Hao, Yuan, Stanley, Robyn, Sahu, Soumyadip, Levin, Daniel S, Chen, Ting, Tang, Sittinon, Huang, Hsin-Yi, Meynardie, Mary, Stephens, Janaye, Sherman, Fiona, Chafitz, Alison, Costelloe, Naoise, Rodrigues, Daniel A, Fogarty, Hilda, Kiernan, Miranda G, Cronin, Fiona, Papadopoulos, Eleni, Ploszaj, Magdalena, Weerasekara, Vajira, Deng, Jiehui, Kiely, Patrick, Bardeesy, Nabeel, Vander Heiden, Matthew G, Chonghaile, Triona Ni, Dowling, Catríona M, Wong, Kwok-Kin

“…In KRAS-mutant NSCLC, co-occurring alterations in LKB1 confer a negative prognosis compared with other mutations such as TP53. LKB1 is a tumor suppressor that…”
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Biotransformation of LASSBio-579 and pharmacological evaluation of p-hydroxylated metabolite a N-phenylpiperazine antipsychotic lead compound by Gomes, Tatiana F, Pompeu, Thais E T, Rodrigues, Daniel A, Noël, François, Menegatti, Ricardo, Andrade, Carolina H, Sabino, José R, Gil, Eric S, Dalla Costa, Teresa, Betti, Andresa H, Antonio, Camila B, Rates, Stela M K, Fraga, Carlos A M, Barreiro, Eliezer J, de Oliveira, Valéria

“…Using a combination of docking and molecular dynamics simulations, we predicted that p-hydroxylation by CYP1A2 would be the main metabolic pathway for the…”
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Value of accessibility to Bogotá's bus rapid transit system by RODRÍGUEZ, DANIEL A., TARGA, FELIPE

“…With several successful cases world-wide, bus rapid transit (BRT) has reemerged as a cost-effective transportation alternative for urban mobility. Despite the…”
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