Search Results - "Rodrigues, Cecília M.P"

miR-34a/SIRT1/p53 is suppressed by ursodeoxycholic acid in the rat liver and activated by disease severity in human non-alcoholic fatty liver disease by Castro, Rui E, Ferreira, Duarte M.S, Afonso, Marta B, Borralho, Pedro M, Machado, Mariana V, Cortez-Pinto, Helena, Rodrigues, Cecília M.P

“…Background & Aims Non-alcoholic fatty liver disease (NAFLD) comprises a spectrum of stages from simple steatosis to non-alcoholic steatohepatitis (NASH)…”
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Necroptosis is a key pathogenic event in human and experimental murine models of non-alcoholic steatohepatitis by Afonso, Marta B, Rodrigues, Pedro M, Carvalho, Tânia, Caridade, Marta, Borralho, Paula, Cortez-Pinto, Helena, Castro, Rui E, Rodrigues, Cecília M P

“…Hepatocyte cell death, inflammation and oxidative stress constitute key pathogenic mechanisms underlying non-alcoholic fatty liver disease (NAFLD). We aimed to…”
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Bile acids: regulation of apoptosis by ursodeoxycholic acid by Amaral, Joana D., Viana, Ricardo J.S., Ramalho, Rita M., Steer, Clifford J., Rodrigues, Cecília M.P.

“…Bile acids are a group of molecular species of acidic steroids with peculiar physical-chemical and biological characteristics. At high concentrations they…”
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Tauroursodeoxycholic acid (TUDCA) supplementation prevents cognitive impairment and amyloid deposition in APP/PS1 mice by Lo, Adrian C, Callaerts-Vegh, Zsuzsanna, Nunes, Ana F, Rodrigues, Cecília M.P, D'Hooge, Rudi

“…Abstract Alzheimer's disease (AD) is a neurodegenerative disease hallmarked by extracellular Aβ1–42 containing plaques, and intracellular neurofibrillary…”
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Monoterpene bisindole alkaloids, from the African medicinal plant Tabernaemontana elegans, induce apoptosis in HCT116 human colon carcinoma cells by Mansoor, Tayyab A., Borralho, Pedro M., Dewanjee, Saikat, Mulhovo, Silva, Rodrigues, Cecília M.P., Ferreira, Maria-José U.

“…Tabernaemontana elegans is a medicinal plant used in African traditional medicine to treat several ailments including cancer. The aims of the present study…”
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Bile acids and apoptosis modulation: an emerging role in experimental Alzheimer's disease by Ramalho, Rita M, Viana, Ricardo J.S, Low, Walter C, Steer, Clifford J, Rodrigues, Cecília M.P

“…The potential role of apoptosis in Alzheimer's disease (AD) has been an area of intense research in recent years. Ursodeoxycholic acid (UDCA) and its…”
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Targeting the p53 pathway of apoptosis by Amaral, Joana D, Xavier, Joana M, Steer, Clifford J, Rodrigues, Cecília M P

“…The tumor suppressor protein, p53 is regarded as a key player in tumor suppression, as it promotes growth arrest, apoptosis and cellular senescence, while also…”
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Lytic cell death in metabolic liver disease by Gautheron, Jérémie, Gores, Gregory J., Rodrigues, Cecília M.P.

“…Regulated cell death is intrinsically associated with inflammatory liver disease and is pivotal in governing outcomes of metabolic liver disease. Different…”
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Cell death targets and potential modulators in Alzheimer's disease by Castro, Rui E, Santos, Maria M M, Glória, Paulo M C, Ribeiro, Carlos J A, Ferreira, Duarte M S, Xavier, Joana M, Moreira, Rui, Rodrigues, Cecília M P

“…Apoptosis is now recognized as a normal feature in the development of the nervous system and may also play a role in neurodegenerative disorders, such as…”
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Delivering the promise of miRNA cancer therapeutics by Pereira, Diane M., Rodrigues, Pedro M., Borralho, Pedro M., Rodrigues, Cecília M.P.

“…► Delivery strategies for miRNA modulators (miRNA mimics/inhibitors) in cancer. ► Local versus systemic delivery in vivo. ► Modified miRNA modulators. ►…”
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Inhibition of receptor-interacting protein kinase 1 improves experimental non-alcoholic fatty liver disease by Majdi, Amine, Aoudjehane, Lynda, Ratziu, Vlad, Islam, Tawhidul, Afonso, Marta B., Conti, Filomena, Mestiri, Taïeb, Lagouge, Marie, Foufelle, Fabienne, Ballenghien, Florine, Ledent, Tatiana, Moldes, Marthe, Cadoret, Axelle, Fouassier, Laura, Delaunay, Jean-Louis, Aït-Slimane, Tounsia, Courtois, Gilles, Fève, Bruno, Scatton, Olivier, Prip-Buus, Carina, Rodrigues, Cecília M.P., Housset, Chantal, Gautheron, Jérémie

“…In non-alcoholic fatty liver disease (NAFLD), hepatocytes can undergo necroptosis: a regulated form of necrotic cell death mediated by the receptor-interacting…”
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Electrochemical sensing of ecstasy with electropolymerized molecularly imprinted poly(o-phenylenediamine) polymer on the surface of disposable screen-printed carbon electrodes by Couto, Rosa A.S., Costa, Séfora S., Mounssef, Bassim, Pacheco, João G., Fernandes, Eduarda, Carvalho, Félix, Rodrigues, Cecília M.P., Delerue-Matos, Cristina, Braga, Ataualpa A.C., Moreira Gonçalves, Luís, Quinaz, M. Beatriz

“…[Display omitted] •Electroanalysis of ecstasy (MDMA) using screen-printed carbon electrodes (SPCEs).•Molecularly imprinted polymers (MIPs) were developed for…”
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Decoding the role of leptin and adiponectin in obesity-related gastrointestinal cancer by Marques, Vanda, Arella, Fabiola, Afonso, Marta B, Santos, André A, Rodrigues, Cecília M P

“…The increasing prevalence of obesity brings forward its importance as a risk factor for cancer development, particularly in the gastrointestinal tract. Obesity…”
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Bilirubin directly disrupts membrane lipid polarity and fluidity, protein order, and redox status in rat mitochondria by Rodrigues, Cecı́lia M.P, Solá, Susana, Brito, Maria A, Brites, Dora, Moura, José J.G

“…Background/Aims : Unconjugated bilirubin (UCB) impairs crucial aspects of cell function and induces apoptosis in primary cultured neurones. While mechanisms of…”
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Amyloid-β pathology is attenuated by tauroursodeoxycholic acid treatment in APP/PS1 mice after disease onset by Dionísio, Pedro A, Amaral, Joana D, Ribeiro, Maria F, Lo, Adrian C, D'Hooge, Rudi, Rodrigues, Cecília M.P

“…Abstract Alzheimer's disease (AD) is a neurodegenerative disorder hallmarked by the accumulation of extracellular amyloid-β (Aβ) peptide and intraneuronal…”
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Death receptors and mitochondria: Two prime triggers of neural apoptosis and differentiation by Solá, Susana, Morgado, Ana L., Rodrigues, Cecília M.P.

“…Stem cell therapy is a strategy far from being satisfactory and applied in the clinic. Poor survival and differentiation levels of stem cells after…”
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Impaired cross-talk between the thioredoxin and glutathione systems is related to ASK-1 mediated apoptosis in neuronal cells exposed to mercury by Branco, Vasco, Coppo, Lucia, Solá, Susana, Lu, Jun, Rodrigues, Cecília M.P., Holmgren, Arne, Carvalho, Cristina

“…Mercury (Hg) compounds target both cysteine (Cys) and selenocysteine (Sec) residues in peptides and proteins. Thus, the components of the two major cellular…”
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Contrasting apoptotic responses of conjugated linoleic acid in the liver of obese Zucker rats fed palm oil or ovine fat by Lopes, Paula A, Martins, Susana V, Viana, Ricardo S.J, Ramalho, Rita M, Alfaia, Cristina M, Pinho, Mário S, Jerónimo, Eliana, Bessa, Rui J.B, Castro, Matilde F, Rodrigues, Cecília M.P, Prates, José A.M

“…Abstract We hypothesized that reducing weight properties of conjugated linoleic acid (CLA) are due to adipocyte apoptosis and that CLA differentially modulates…”
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Preclinical validation of a new hybrid molecule loaded in liposomes for melanoma management by Pinho, Jacinta O., Matias, Mariana, Marques, Vanda, Eleutério, Carla, Fernandes, Célia, Gano, Lurdes, Amaral, Joana D., Mendes, Eduarda, Perry, Maria Jesus, Moreira, João Nuno, Storm, Gert, Francisco, Ana Paula, Rodrigues, Cecília M.P., Gaspar, M. Manuela

“…The aggressiveness of melanoma and lack of effective therapies incite the discovery of novel strategies. Recently, a new dual acting hybrid molecule (HM),…”
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Organelle stress sensors and cell death mechanisms in neurodegenerative diseases by Viana, Ricardo J S, Fonseca, Maria B, Ramalho, Rita M, Nunes, Ana F, Rodrigues, Cecília M P

“…Neurodegenerative diseases trigger neuronal cell death by a variety of endogenous suicide pathways. Although cell death may occur through highly heterogeneous…”
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