Search Results - "Rodrigues, Carolina C."
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Bortezomib suppresses acute myelogenous leukaemia stem‐like KG‐1a cells via NF‐κB inhibition and the induction of oxidative stress
Published in Journal of cellular and molecular medicine (01-04-2024)“…Acute myelogenous leukaemia (AML) originates and is maintained by leukaemic stem cells (LSCs) that are inherently resistant to antiproliferative therapies,…”
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Multiple Wire-Mesh Sensors Applied to the Characterization of Two-Phase Flow inside a Cyclonic Flow Distribution System
Published in Sensors (Basel, Switzerland) (07-01-2019)“…Wire-mesh sensors are used to determine the phase fraction of gas⁻liquid two-phase flow in many industrial applications. In this paper, we report the use of…”
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3
Mercury in muscle and brain of catfish from the Madeira river, Amazon, Brazil
Published in Ecotoxicology and environmental safety (01-08-2015)“…The central nervous system is a critical target for Hg toxicity in all living organisms. Total Hg (THg) was determined in brain and muscle samples of 165…”
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4
Tingenone and 22-hydroxytingenone target oxidative stress through downregulation of thioredoxin, leading to DNA double-strand break and JNK/p38-mediated apoptosis in acute myeloid leukemia HL-60 cells
Published in Biomedicine & pharmacotherapy (01-10-2021)“…Acute myeloid leukemia (AML) is the most lethal form of leukemia. Standard anti-AML treatment remains almost unchanged for decades. Tingenone (TG) and…”
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5
Essential Oil from Bark of Aniba parviflora (Meisn.) Mez (Lauraceae) Reduces HepG2 Cell Proliferation and Inhibits Tumor Development in a Xenograft Model
Published in Chemistry & biodiversity (01-03-2021)“…Aniba parviflora (Meisn.) Mez (Lauraceae) is an aromatic plant of the Amazon rainforest, which has a tremendous commercial value in the perfumery industry; it…”
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Emetine induces oxidative stress, cell differentiation and NF-κB inhibition, suppressing AML stem/progenitor cells
Published in Cell death discovery (29-04-2024)“…Acute myeloid leukemia (AML) is a fatal malignancy of the blood and bone marrow. Leukemic stem cells (LSCs) are a rare subset of leukemic cells that promote…”
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Piplartine eliminates CD34 + AML stem/progenitor cells by inducing oxidative stress and suppressing NF-κB signalling
Published in Cell death discovery (19-03-2024)“…Acute myeloid leukaemia (AML) is a haematological malignancy characterised by the accumulation of transformed myeloid progenitors in the bone marrow…”
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Emerging drugs targeting cellular redox homeostasis to eliminate acute myeloid leukemia stem cells
Published in Redox biology (01-06-2023)“…Acute myeloid leukemia (AML) is a very heterogeneous group of disorders with large differences in the percentage of immature blasts that presently are…”
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9
Cytotoxic Alkaloids from the Stem of Xylopia laevigata
Published in Molecules (Basel, Switzerland) (08-07-2016)“…Xylopia laevigata (Annonaceae), known locally as "meiú" or "pindaíba", is widely used in folk medicine in Northeastern Brazil. In the present work, we…”
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Experimental characterization of the dispersed bubbles in the slug of an air–water slug flow in a vertical pipe
Published in Journal of the Brazilian Society of Mechanical Sciences and Engineering (01-09-2023)“…Slug flow is one among the different flow patterns that two-phase flows can assume. This pattern is composed of a Taylor bubble and a liquid slug and can…”
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Bithionol eliminates acute myeloid leukaemia stem-like cells by suppressing NF-κB signalling and inducing oxidative stress, leading to apoptosis and ferroptosis
Published in Cell death discovery (29-08-2024)“…Acute myeloid leukaemia (AML) is a lethal bone marrow neoplasm caused by genetic alterations in blood cell progenitors. Leukaemic stem cells (LSCs) are…”
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12
Cell signaling pathways as molecular targets to eliminate AML stem cells
Published in Critical reviews in oncology/hematology (01-04-2021)“…•Acute myeloid leukemia remains the most lethal of leukemias.•Leukemic stem cells are associated with disease relapses.•Cell signaling pathways are targets to…”
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Ruthenium Complexes Containing Heterocyclic Thioamidates Trigger Caspase-Mediated Apoptosis Through MAPK Signaling in Human Hepatocellular Carcinoma Cells
Published in Frontiers in oncology (09-07-2019)“…Herein, ruthenium complexes containing heterocyclic thioamidates [Ru(mmi)(bipy)(dppb)]PF ( ), [Ru(tzdt)(bipy)(dppb)]PF ( ), [Ru(dmp)(bipy)(dppb)]PF ( ) and…”
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Photocatalytic degradation of dyes by mononuclear copper(II) complexes from bis-(2-pyridylmethyl)amine NNN-derivative ligands
Published in Inorganica Chimica Acta (01-11-2020)“…[Display omitted] •Copper(II) complexes were studied as catalysts for pollutant dye photodegradation.•Methyl orange, Congo red, methylene blue, crystal violet,…”
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In vitro and in vivo anti-leukemia activity of the stem bark of Salacia impressifolia (Miers) A. C. Smith (Celastraceae)
Published in Journal of ethnopharmacology (01-03-2019)“…Salacia impressifolia (Miers) A. C. Smith (family Celastraceae) is a traditional medicinal plant found in the Amazon Rainforest known as “miraruíra”,…”
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Cytotoxic potential of selected medicinal plants in northeast Brazil
Published in BMC complementary and alternative medicine (08-07-2016)“…Great biodiversity is a highlight of Brazilian flora. In contrast, the therapeutic potentialities of most species used in folk medicine remain unknown. Several…”
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Antitumour Activity of the Microencapsulation of Annona vepretorum Essential Oil
Published in Basic & clinical pharmacology & toxicology (01-03-2016)“…Annona vepretorum Mart. (Annonaceae), popularly known as ‘bruteira’, has nutritional and medicinal uses. This study investigated the chemical composition and…”
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Antitumor Properties of the Essential Oil From the Leaves of Duguetia gardneriana
Published in Planta medica (01-07-2015)“…Duguetia gardneriana, popularly known in the Brazilian northeast as "jaquinha", is a species belonging to the family Annonaceae. The aim of this work was to…”
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Spatial distribution of void fraction in the liquid slug in vertical Gas-Liquid slug flow
Published in Experimental thermal and fluid science (01-02-2024)Get full text
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20
Melipona mondury produces a geopropolis with antioxidant, antibacterial and antiproliferative activities
Published in Anais da Academia Brasileira de Ciências (01-01-2017)“…Geopropolis is a special type of propolis produced by stingless bees. Several pharmacological properties have been described for different types of…”
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