Search Results - "Rodrigues, Antonio Sebastiao"

Anthocyanin recovery from grape by-products by combining ohmic heating with food-grade solvents: phenolic composition, antioxidant, and antimicrobial properties by Coelho, M., Silva, Sara, Costa, Eduardo, Pereira, Ricardo Nuno Correia, Rodrigues, António Sebastião, Teixeira, J. A., Pintado, Manuela

“…Usually, wine-making by-products are discarded, presenting a significant environmental impact. However, they can be used as a source of bioactive compounds…”
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Whole human genome 5'-mC methylation analysis using long read nanopore sequencing by Silva, Catarina, Machado, Miguel, Ferrão, José, Sebastião Rodrigues, António, Vieira, Luís

“…Methylation microarray and bisulphite sequencing are often used to study 5'-methylcytosine (5'-mC) modification of CpG dinucleotides in the human genome…”
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In Vitro Gastrointestinal Digestion Impact on the Bioaccessibility and Antioxidant Capacity of Bioactive Compounds from Tomato Flours Obtained after Conventional and Ohmic Heating Extraction by Coelho, Marta C, Ribeiro, Tânia B, Oliveira, Carla, Batista, Patricia, Castro, Pedro, Monforte, Ana Rita, Rodrigues, António Sebastião, Teixeira, José, Pintado, Manuela

“…In times of pandemic and when sustainability is in vogue, the use of byproducts, such as fiber-rich tomato byproducts, can be an asset. There are still no…”
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Motor dysfunction in Drosophila melanogaster as a biomarker for developmental neurotoxicity by Cabrita, Ana, Medeiros, Alexandra M., Pereira, Telmo, Rodrigues, António Sebastião, Kranendonk, Michel, Mendes, César S.

“…Adequate alternatives to conventional animal testing are needed to study developmental neurotoxicity (DNT). Here, we used kinematic analysis to assess DNT of…”
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Cancer Drug Resistance: A Brief Overview from a Genetic Viewpoint by Rueff, José, Rodrigues, António Sebastião

“…Cancer drug resistance leading to therapeutic failure in the treatment of many cancers encompasses various mechanisms and may be intrinsic relying on the…”
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Instability of mRNA expression signatures of drug transporters in chronic myeloid leukemia patients resistant to imatinib by GROMICHO, MARTA, MAGALHÃES, MARTA, TORRES, FÁTIMA, DINIS, JOANA, FERNANDES, ALEXANDRA R, RENDEIRO, PAULA, TAVARES, PURIFICAÇÃO, LAIRES, ANTÓNIO, RUEFF, JOSÉ, RODRIGUES, ANTÓNIO SEBASTIÃO

“…Despite the success of imatinib mesylate (IM) in the treatment of chronic myeloid leukemia (CML), approximately 30% of patients are resistant to therapy,…”
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Brassica oleracea L. Var. costata DC and Pieris brassicae L. Aqueous Extracts Reduce Methyl Methanesulfonate-Induced DNA Damage in V79 Hamster Lung Fibroblasts by Sousa, Carla, Fernandes, Fátima, Valentão, Patrícia, Rodrigues, António Sebastião, Coelho, Marta, Teixeira, João P, Silva, Susana, Ferreres, Federico, de Pinho, Paula Guedes, Andrade, Paula B

“…Brassica oleracea L. var. costata DC leaves and Pieris brassicae L. larvae aqueous extracts were assayed for their potential to prevent/induce DNA damage. None…”
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Differential Expression of miRNAs in Amyotrophic Lateral Sclerosis Patients by Gomes, Bruno Costa, Peixinho, Nuno, Pisco, Rita, Gromicho, Marta, Pronto-Laborinho, Ana Catarina, Rueff, José, de Carvalho, Mamede, Rodrigues, António Sebastião

“…Amyotrophic lateral sclerosis (ALS) is a progressive motor neuron disease that affects nerve cells in the brain and spinal cord, causing loss of muscle…”
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MicroRNAs and Cancer Drug Resistance by Gomes, Bruno Costa, Rueff, José, Rodrigues, António Sebastião

“…The discovery of small regulatory noncoding RNAs revolutionized our thinking on gene regulation. The class of microRNAs (miRs), a group of small noncoding RNAs…”
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Male and female breast cancer: the two faces of the same genetic susceptibility coin by Silva, Susana Nunes, Gomes, Bruno Costa, André, Saudade, Félix, Ana, Rodrigues, António Sebastião, Rueff, José

“…Background Breast cancer (BC) is the most common cancer in women. In contrast, male BC is about 100 times less common than in women, being considered a rare…”
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Copy number variations and constitutional chromothripsis (Review) by Bras, Aldina, Rodrigues, Antonio Sebastiao, Rueff, Jose

“…Both copy number variations (CNVs) and chromothripsis are phenomena that involve complex genomic rearrangements. Chromothripsis results in CNVs and other…”
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Methods for Studying MicroRNA Expression and Their Targets in Formalin-Fixed, Paraffin-Embedded (FFPE) Breast Cancer Tissues by Gomes, Bruno Costa, Santos, Bruno, Rueff, José, Rodrigues, António Sebastião

“…Drug resistance remains a burden in cancer treatment. In the past few years molecular genetics brought a new hope with personalized therapy. This individual…”
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Fluorimetric Methods for Analysis of Permeability, Drug Transport Kinetics, and Inhibition of the ABCB1 Membrane Transporter by Armada, Ana, Martins, Célia, Spengler, Gabriella, Molnar, Joseph, Amaral, Leonard, Rodrigues, António Sebastião, Viveiros, Miguel

“…The cell membrane P-glycoprotein (P-gp; MDR1, ABCB1) is an energy-dependent efflux pump that belongs to the ATP-binding cassette (ABC) family of transporters,…”
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Genetic Susceptibility in Acute Pancreatitis: Genotyping of GSTM1, GSTT1, GSTP1, CASP7, CASP8, CASP9, CASP10, LTA, TNFRSF1B, and TP53 Gene Variants by Dʼ Oliveira Martins, Francisco, Gomes, Bruno Costa, Rodrigues, António Sebastião, Rueff, José

“…Genetic testing could play a critical role in diagnosis and prognosis of acute pancreatitis (AP) and guide effective therapeutic interventions. We hypothesized…”
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Dynamics of Expression of Drug Transporters: Methods for Appraisal by Gromicho, Marta, Rueff, José, Rodrigues, António Sebastião

“…Cellular drug resistance remains a major concern in cancer therapy and usually results from increased expression of ABC drug transporters. Imatinib mesylate…”
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Prognostic value of microRNA-203a expression in breast cancer by Gomes, Bruno Costa, Martins, Manuela, Lopes, Paulina, Morujão, Inês, Oliveira, Mário, Araújo, António, Rueff, José, Rodrigues, António Sebastião

“…Tumor heterogeneity and the poor outcome of breast cancer (BC) patients have led researchers to define new markers of this disease. In recent years, microRNA…”
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BRCA1 VUS: A functional analysis to differentiate pathogenic from benign variants identified in clinical diagnostic panels for breast cancer by Lourenço, Rita Adubeiro, Lança, Miguel, Monteiro Gil, Octávia, Cardoso, Joana, Lourenço, Teresa, Pereira-Leal, José B, Rodrigues, António Sebastião, Rueff, José, Nunes Silva, Susana

“…Genetic testing for susceptibility genes through next‑generation sequencing (NGS) has become a widely used technique. Using this, a number of genetic variants…”
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MicroRNAs and cancer drug resistance: over two thousand characters in search of a role by Gomes, Bruno Costa, Rueff, José, Rodrigues, António Sebastião

“…MicroRNAs (miRNAs), a group of small regulatory noncoding RNAs, transformed our thinking on gene regulation. More than two thousand human miRNAs have been…”
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Development of imatinib and dasatinib resistance: dynamics of expression of drug transporters ABCB1, ABCC1, ABCG2, MVP, and SLC22A1 by Gromicho, Marta, Dinis, Joana, Magalhães, Marta, Fernandes, Alexandra R., Tavares, Purificação, Laires, António, Rueff, José, Rodrigues, António Sebastião

“…About 20% of patients with chronic myeloid leukemia (CML) do not respond to treatment with imatinib either initially or because of acquired resistance. To…”
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Regulation of ABCB1 activity by microRNA-200c and microRNA-203a in breast cancer cells: the quest for microRNAs' involvement in cancer drug resistance by Armada, Ana, Gomes, Bruno Costa, Viveiros, Miguel, Rueff, José, Rodrigues, António Sebastião

“…ABCB1 is a major player in cancer drug resistance. The purpose of this study was to functionally assess the regulation of ABCB1 activity in a…”
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