Search Results - "Rodrigues, Andria V."
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Accurate prediction of protein structures and interactions using a three-track neural network
Published in Science (American Association for the Advancement of Science) (20-08-2021)“…DeepMind presented notably accurate predictions at the recent 14th Critical Assessment of Structure Prediction (CASP14) conference. We explored network…”
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Cleavage and polyadenylation specificity factor 30: An RNA-binding zinc-finger protein with an unexpected 2Fe–2S cluster
Published in Proceedings of the National Academy of Sciences - PNAS (26-04-2016)“…Cleavage and polyadenylation specificity factor 30 (CPSF30) is a key protein involved in pre-mRNA processing. CPSF30 contains five Cys₃His domains (annotated…”
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Insight into the Mechanism of Phenylacetate Decarboxylase (PhdB), a Toluene‐Producing Glycyl Radical Enzyme
Published in Chembiochem : a European journal of chemical biology (02-03-2020)“…We recently reported the discovery of phenylacetate decarboxylase (PhdB), representing one of only ten glycyl‐radical‐enzyme reaction types known, and a…”
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Characterization of lignin-degrading enzyme PmdC, which catalyzes a key step in the synthesis of polymer precursor 2-pyrone-4,6-dicarboxylic acid
Published in The Journal of biological chemistry (01-10-2024)“…Pyrone-2,4-dicarboxylic acid (PDC) is a valuable polymer precursor that can be derived from the microbial degradation of lignin. The key enzyme in the…”
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Drosophila melanogaster frataxin: protein crystal and predicted solution structure with identification of the iron‐binding regions
Published in Acta crystallographica. Section D, Biological crystallography. (01-01-2023)“…Friedreich's ataxia (FRDA) is a hereditary cardiodegenerative and neurodegenerative disease that affects 1 in 50 000 Americans. FRDA arises from either a…”
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Discovery of enzymes for toluene synthesis from anoxic microbial communities
Published in Nature chemical biology (01-05-2018)“…Microbial toluene biosynthesis was reported in anoxic lake sediments more than three decades ago, but the enzyme catalyzing this biochemically challenging…”
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Synthesis of Co(II)-NO(-) Complexes and Their Reactivity as a Source of Nitroxyl
Published in Journal of the American Chemical Society (28-09-2016)“…Metal-nitroxyl (M-HNO/M-NO(-)) coordination units are found in denitrification enzymes of the global nitrogen cycle, and free HNO exhibits pharmacological…”
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Unique roles of iron and zinc binding to the yeast Fe-S cluster scaffold assembly protein "Isu1"
Published in Metallomics (01-11-2019)“…Mitochondrial Fe-S cluster biosynthesis is accomplished within yeast utilizing the biophysical attributes of the "Isu1" scaffold assembly protein. As a member…”
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Discovery of novel geranylgeranyl reductases and characterization of their substrate promiscuity
Published in Biotechnology for biofuels (28-12-2018)“…Geranylgeranyl reductase (GGR) is a flavin-containing redox enzyme that hydrogenates a variety of unactivated polyprenyl substrates, which are further…”
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Iron chaperones for mitochondrial Fe–S cluster biosynthesis and ferritin iron storage
Published in Current opinion in chemical biology (01-04-2011)“…Protein controlled iron homeostasis is essential for maintaining appropriate levels and availability of metal within cells. Recently, two iron chaperones have…”
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Iron loading site on the Fe–S cluster assembly scaffold protein is distinct from the active site
Published in Biometals (01-06-2015)“…Iron–sulfur (Fe–S) cluster containing proteins are utilized in almost every biochemical pathway. The unique redox and coordination chemistry associated with…”
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Backbone resonance assignments and secondary structure of the apo-Drosophila melanogaster frataxin homolog (Dfh)
Published in Biomolecular NMR assignments (15-10-2019)“…Friedreich’s ataxia, the most prevalent hereditary ataxia, is caused by a patient’s inability to produce a viable form of the protein frataxin. Frataxin plays…”
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Proton-Induced Reactivity of NO– from a {CoNO}8 Complex
Published in Journal of the American Chemical Society (10-09-2014)“…Research on the one-electron reduced analogue of NO, namely nitroxyl (HNO/NO–), has revealed distinguishing properties regarding its utility as a therapeutic…”
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Synthesis of Co II –NO – Complexes and Their Reactivity as a Source of Nitroxyl
Published in Journal of the American Chemical Society (28-09-2016)Get full text
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Proton-Induced Reactivity of NO¿ from a {CoNO}(8) Complex
Published in Journal of the American Chemical Society (10-09-2014)Get full text
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Accurate prediction of protein structures and interactions using a 3-track neural network
Published in Science (American Association for the Advancement of Science) (15-07-2021)“…DeepMind presented remarkably accurate predictions at the recent CASP14 protein structure prediction assessment conference. We explored network architectures…”
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Journal Article -
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Characterization of initial iron binding location and the structure/iron binding site on S. cerevisiae isu and on D. melanogaster frataxin
Published 01-01-2014“…Iron-induced free radical damage has been implicated in the pathology of diseases of iron overload such as Friedreich's Ataxia, a genetic disorder…”
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Dissertation -
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Synthesis of CoII–NO– Complexes and Their Reactivity as a Source of Nitroxyl
Published in Journal of the American Chemical Society (28-09-2016)“…Metal-nitroxyl (M–HNO/M–NO–) coordination units are found in denitrification enzymes of the global nitrogen cycle, and free HNO exhibits pharmacological…”
Get full text
Journal Article