Antinociceptive Activities of the Hydroalcoholic Extracts from Erythrina velutina and Erythrina mulungu in Mice

Antinociceptive Activities of the Hydroalcoholic Extracts from Erythrina velutina and Erythrina mulungu in Mice

This work studied the antinociceptive effects of the hydroalcoholic extracts (HAEs) from Erythrina velutina (Ev) and Erythrina mulungu (Em) in three experimental models of nociception in mice. The extract was administered intraperitoneally to female mice at the doses of 200 and 400 mg/kg. Inhibition...

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Bibliographic Details
Published in:Biological & pharmaceutical bulletin Vol. 26; no. 7; pp. 946 - 949
Main Authors: Vasconcelos, Silvânia Maria Mendes, Oliveira, Glício Rebouças, Carvalho, Manuella Mohana de, Rodrigues, Alexandre César Praxedes, Silveira, Edilberto Rocha, Fonteles, Marta Maria França, Sousa, Francisca Cléa Florenço, Viana, Glauce Socorro Barros
Format: Journal Article
Language:English
Published: Tokyo The Pharmaceutical Society of Japan 01-07-2003
Maruzen
Japan Science and Technology Agency
Subjects:
Analgesics - isolation & purification
Analgesics - pharmacology
Animals
antinociceptive activity
Biological and medical sciences
Erythrina
Erythrina mulungu
Erythrina velutina
Female
General pharmacology
Male
Medical sciences
Mice
Morphine - pharmacology
Naloxone - pharmacology
Pain Measurement - methods
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Plant Bark
Plant Extracts - isolation & purification
Plant Extracts - pharmacology
Vertebrata
Mammalia
Analgesic
Mouse
Animal
Rodentia
Extract
Erythrina mulungu
Erythrina velutina
antinociceptive activity
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Summary:This work studied the antinociceptive effects of the hydroalcoholic extracts (HAEs) from Erythrina velutina (Ev) and Erythrina mulungu (Em) in three experimental models of nociception in mice. The extract was administered intraperitoneally to female mice at the doses of 200 and 400 mg/kg. Inhibitions of abdominal contractions were observed with the doses of 200 (88.6%; 86.8%) and 400 (95.5%; 83.5%) mg/kg of E. velutina and E. mulungu, respectively, as compared to controls. E. velutina and E. mulungu, at both doses, reduced the nociception produced by formalin in the 1st and 2nd phases and this effect was not reversed by the pretreatment with naloxone. In the hot plate test an increase of the reaction time was observed only at 60 (Ev=18.0±2.2; Em=20.8±2.52) and 90 min (Ev=20.4±1.71; Em=23.7±2.32) after the treatment with E. velutina and E. mulungu at the dose of 400 mg/kg as compared to controls (T60=11.1±0.74; T90=11.9±0.86). This effect was not reversed by naloxone. We conclude that E. velutina and E. mulungu presents antinociceptive effects, which are independent of the opioid system.
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ISSN:0918-6158
1347-5215
DOI:10.1248/bpb.26.946