Search Results - "Rodríguez‐Ruiz, Maria Esperanza"

Differential Interleukin‐8 thresholds for chemotaxis and netosis in human neutrophils by Teijeira, Alvaro, Garasa, Saray, Ochoa, Maria del Carmen, Cirella, Assunta, Olivera, Irene, Glez‐Vaz, Javier, Andueza, Maria Pilar, Migueliz, Itziar, Alvarez, Maite, Rodríguez‐Ruiz, Maria Esperanza, Rouzaut, Ana, Berraondo, Pedro, Sanmamed, Miguel F., Perez Gracia, Jose L., Melero, Ignacio

“…In humans, IL‐8 (CXCL8) is a key chemokine for chemotaxis of polymorphonuclear leukocytes and monocytes/macrophages when acting on CXCR1 and CXCR2. CXCL8…”
Get full text

Apoptotic caspases cut down the immunogenicity of radiation by Buqué, Aitziber, Rodriguez-Ruiz, Maria Esperanza, Fucikova, Jitka, Galluzzi, Lorenzo

“…Caspases are known for their ability to precipitate apoptosis. Our findings indicate that accelerating the terminal inactivation of cells dying in response to…”
Get full text

Immunological impact of cell death signaling driven by radiation on the tumor microenvironment by Rodriguez-Ruiz, Maria Esperanza, Vitale, Ilio, Harrington, Kevin J., Melero, Ignacio, Galluzzi, Lorenzo

“…Therapeutic irradiation of the tumor microenvironment causes differential activation of pro-survival and pro-death pathways in malignant, stromal, endothelial…”
Get full text

Prophylactic TNF blockade uncouples efficacy and toxicity in dual CTLA-4 and PD-1 immunotherapy by Perez-Ruiz, Elisabeth, Minute, Luna, Otano, Itziar, Alvarez, Maite, Ochoa, Maria Carmen, Belsue, Virginia, de Andrea, Carlos, Rodriguez-Ruiz, Maria Esperanza, Perez-Gracia, Jose Luis, Marquez-Rodas, Ivan, Llacer, Casilda, Alvarez, Martina, de Luque, Vanesa, Molina, Carmen, Teijeira, Alvaro, Berraondo, Pedro, Melero, Ignacio

“…Combined PD-1 and CTLA-4-targeted immunotherapy with nivolumab and ipilimumab is effective against melanoma, renal cell carcinoma and non-small-cell lung…”
Get full text

Apoptotic caspases inhibit abscopal responses to radiation and identify a new prognostic biomarker for breast cancer patients by Rodriguez-Ruiz, Maria Esperanza, Buqué, Aitziber, Hensler, Michal, Chen, Jonathan, Bloy, Norma, Petroni, Giulia, Sato, Ai, Yamazaki, Takahiro, Fucikova, Jitka, Galluzzi, Lorenzo

“…Caspase 3 (CASP3) has a key role in the execution of apoptosis, and many cancer cells are believed to disable CASP3 as a mechanism of resistance to cytotoxic…”
Get full text

Pneumomediastinum as a complication of SABR for lung metastases by Rodríguez-Ruiz, María Esperanza, Arévalo, Estefanía, Gil-Bazo, Ignacio, Olarte García, Alicia, Valtueña, German, Moreno-Jiménez, Marta, Arbea-Moreno, Leire, Aristu, Javier

“…Stereotactic ablative body radiation (SABR) is a novel and sophisticated radiation modality that involves the irradiation of extracranial tumors through…”
Get full text

Pathological vertebral fracture after stereotactic body radiation therapy for lung metastases. Case report and literature review by Rodríguez-Ruiz, María Esperanza, San Miguel, Iñigo, Gil-Bazo, Ignacio, Perez-Gracia, Jose Luis, Arbea, Leire, Moreno-Jimenez, Marta, Aristu, Javier

“…Stereotactic body radiation therapy (SBRT) is a radiation technique used in patients with oligometastatic lung disease. Lung and chest wall toxicities have…”
Get full text

Strategies to design clinical studies to identify predictive biomarkers in cancer research by Luis Perez-Gracia, Jose, Sanmamed, Miguel F, Bosch, Ana, Patiño-Garcia, Ana, Schalper, Kurt A, Segura, Victor, Bellmunt, Joaquim, Tabernero, Josep, Sweeney, Christopher J, Choueiri, Toni K, Martín, Miguel, Pablo Fusco, Juan, Esperanza Rodriguez-Ruiz, Maria, Calvo, Alfonso, Prior, Celia, Paz-Ares, Luis, Pio, Ruben, Gonzalez Billalabeitia, Enrique, Gonzalez Hernandez, Alvaro, Páez, David, María Piulats, Jose, Gurpide, Alfonso, Andueza, Mapi, de Velasco, Guillermo, Pazo, Roberto, Grande, Enrique, Nicolas, Pilar, Abad-Santos, Francisco, Garcia-Donas, Jesus, Castellano, Daniel, Pajares, María J, Suarez, Cristina, Colomer, Ramon, Montuenga, Luis M, Melero, Ignacio

“…Highlights • Predictive biomarkers are essential to improve the efficacy of anticancer drugs. • Biomarker identification requires well-designed studies that…”
Get full text

International Symposium: Trailblazing in Cancer Immunotherapy, October 29–31, 2017, Pamplona, Spain by Berraondo, Pedro, Aznar, Maria Angela, Perez-Ruiz, Elisabeth, Rodriguez-Ruiz, Maria Esperanza, Castañon, Eduardo, Perez-Gracia, Jose Luis, Melero, Ignacio

Get full text

Endoscopical and pathological dissociation in severe colitis induced by immune-checkpoint inhibitors by de Andrea, Carlos Eduardo, Perez-Gracia, Jose Luis, Castanon, Eduardo, Ponz-Sarvise, Mariano, Echeveste, Jose I, Melero, Ignacio, Sanmamed, Miguel F, Rodriguez-Ruiz, Maria Esperanza

“…Checkpoint inhibitors have improved the survival of patients with advanced tumors and show a manageable toxicity profile. However, auto-immune colitis remains…”
Get full text

Abstract 1698: Cellular cytotoxicity is a form of immunogenic cell death by Minute, Luna, Teijeira, Alvaro, Sánchez-Paulete, Alfonso Rodriguez, del Carmen Ochoa, Maria, Alvarez, Maite, Otano, Itziar, Etxeberria, Iñaki, Bolaños, Elixabet, Azpilikueta, Arantza, Garasa, Saray, Casares, Noelia, Pérez-Gracia, José Luiz, Rodríguez-Ruiz, Maria Esperanza, Berraondo, Pedro, Melero, Ignacio

“…Background: The immune response to cancer is often conceptualized with the Cancer Immunity Cycle. An essential step in this interpretation is that antigens…”
Get full text

A simple method to assess clonogenic survival of irradiated cancer cells by Serrano-Mendioroz, Irantzu, Garate-Soraluze, Eneko, Rodriguez-Ruiz, María Esperanza

“…The clonogenic assay is an in vitro method based on the ability of a single cell to proliferate indefinitely into a colony. This assay is the gold standard…”
Get full text

Flow cytometry-assisted quantification of immune cells infiltrating irradiated tumors in mice by Labiano, Sara, Serrano-Mendioroz, Irantzu, Rodriguez-Ruiz, María Esperanza

“…The immunomodulatory properties of local hypofractionated radiotherapy are known to promote the generation of anti-tumor immune responses. Such responses are…”
Get full text

Immunostimulatory Monoclonal Antibodies and Immunomodulation: Harvesting the Crop by Berraondo, Pedro, Ochoa, María Carmen, Rodriguez-Ruiz, María Esperanza, Minute, Luna, Lasarte, Juan José, Melero, Ignacio

“…The recent approval by the FDA of the combination of anti-CTLA4 and anti-PD-1 mAbs for the treatment of BRAF-unmutated unresectable or metastatic melanoma is a…”
Get full text

Abstract CT176: Pharmacokinetic/pharmacodynamic (PK/PD) relationships of the novel Treg depleter RG6292 in Phase Ia and Ib studies in patients with solid tumors by Tanos, Tamara, Smart, Kevin, Gambardella, Valentina, Rohrberg, Kristoffer, Ong, Michael, Rodriguez Ruiz, Maria Esperanza, Machiels, Jean-Pascal, Sanmamed, Miguel Fernández, Tabernero, Josep, Spreafico, Anna, Renouf, Daniel, Luen, Stephen, Galot, Rachel, Doger, Bernard, Calvo, Emiliano, Naing, Aung, Curdt, Samira, Staedler, Nicolas, Flores, Mike, Alcaide, Enrique Gómez, Ooi, Chiahuey, Hettich, Michael, Dziadek, Sebastian, Xie, Yuying, Schnetzler, Gabriel, Kolben, Theresa, Xu, Linxinyu, Karanikas, Vaios, Boetsch, Christophe

“…INTRODUCTION: Activated Tregs in the tumor micro-environment are correlated with poor outcomes, and are considered as key players in tumor immune-escape. So…”
Get full text

Abstract CT110: Safety and anti-tumor activity of a novel Treg depleter RG6292, as a single agent and in combination with atezolizumab in patients with solid tumors by Gambardella, Valentina, Ong, Michael, Ruiz, Maria Esperanza Rodriguez, Machiels, Jean-Pascal, de Sanmamed, Miguel Fernandez, Tabernero, Josep Maria, Spreafico, Anna, Renouf, Daniel J, Luen, Stephen J, Galot, Rachel, de Speville Uribe, Bernard Doger, Aller, Emiliano Calvo, Naing, Aung, Curdt, Samira, Rossmann, Eva, Tanos, Tamara, Smart, Kevin, Amann, Maria, Xie, Yuying, Schnetzler, Gabriel, Boetsch, Christophe, Karanikas, Vaios, Kolben, Theresa, Xu, Linxinyu, Rohrberg, Kristoffer S

“…Background RG6292 is the first anti-human CD25 antibody developed to specifically deplete human Tregs while preserving IL-2R STAT5 signaling and Teff activity…”
Get full text

Assessment of hypoxia by pimonidazole staining following radiotherapy by Labiano, Sara, Serrano-Mendioroz, Irantzu, Rodriguez-Ruiz, María Esperanza

Get full text

Endoscopical and pathological dissociation in severe colitis induced by immune-checkpoint inhibitors by de Andrea, Carlos Eduardo, Perez-Gracia, Jose Luis, Castanon, Eduardo, Ponz-Sarvise, Mariano, Echeveste, Jose I., Melero, Ignacio, Sanmamed, Miguel F., Rodriguez-Ruiz, Maria Esperanza

“…Checkpoint inhibitors have improved the survival of patients with advanced tumors and show a manageable toxicity profile. However, auto-immune colitis remains…”
Get full text