Renal disease in diabetics. Immunological bases of tubule-interstitial fibrosis and glomeruloesclerosis. Current therapeutic approach

Susceptibility of kidney to become target of the immunological aggression is easily recognizable when we consider the high number of diseases that, with a pathogenesis explained by autoimmunity mechanisms, have the kidney as a target organ. In diabetes mellitus, hyperglycemic state stimulates differ...

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Published in:	Revista alergia Mexico (Tecamachalco, Pueblo, Mexico : 1993) Vol. 51; no. 4; pp. 155 - 161
Main Authors:	Orozco, Alain R Rodríguez, Jiménez, Rafael Leyva, Aguilar, Alvarez Cleto, Arredondo, Martha Cortés, Rodríguez, Victor M Farías
Format:	Journal Article
Language:	Spanish
Published:	Mexico 01-07-2004
Subjects:	Angiotensin II - physiology Animals Antigens, Surface Cell Adhesion Molecules - immunology Diabetic Nephropathies - immunology Diabetic Nephropathies - pathology Diabetic Nephropathies - therapy Disease Progression Fibrosis Glycation End Products, Advanced - metabolism Humans Membrane Glycoproteins - immunology Nephritis, Interstitial - immunology Nephritis, Interstitial - pathology Nephritis, Interstitial - therapy NF-kappa B - physiology Protein Kinase C - physiology Transforming Growth Factor beta - physiology Tumor Necrosis Factor-alpha - physiology
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Summary:	Susceptibility of kidney to become target of the immunological aggression is easily recognizable when we consider the high number of diseases that, with a pathogenesis explained by autoimmunity mechanisms, have the kidney as a target organ. In diabetes mellitus, hyperglycemic state stimulates different molecular factors conditioning tubule-interstitial fibrosis and glomerulosclerosis, among them the most important are: formation of products of advanced glycation; activation of protein kinase C, activation of the angiotensin II and the activation of the nuclear factor kappaB. These factors are closely related to the production of inflammatory cytokines and to the progression of renal damage. This paper reviews the role of these factors in the renal damage of diabetic patients and the effect of some drugs on the progression of the immunological damage.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1
ISSN:	0002-5151