Search Results - "Rodríguez, Jake W Carrasquillo"
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Cell cycle regulation of ER membrane biogenesis protects against chromosome missegregation
Published in Developmental cell (20-12-2021)“…Failure to reorganize the endoplasmic reticulum (ER) in mitosis results in chromosome missegregation. Here, we show that accurate chromosome segregation in…”
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Promotion of adipogenesis by JMJD6 requires the AT hook-like domain and is independent of its catalytic function
Published in PloS one (20-08-2019)“…JMJD6 is a member of the Jumonji C domain containing enzymes that demethylate and/or hydroxylate substrate proteins. It is a multi-functional protein that has…”
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A membrane-sensing mechanism links lipid metabolism to protein degradation at the nuclear envelope
Published in The Journal of cell biology (04-09-2023)“…Lipid composition determines organelle identity; however, whether the lipid composition of the inner nuclear membrane (INM) domain of the ER contributes to its…”
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Differential reliance of CTD-nuclear envelope phosphatase 1 on its regulatory subunit in ER lipid synthesis and storage
Published in Molecular biology of the cell (01-07-2024)“…Lipin 1 is an ER enzyme that produces diacylglycerol, the lipid intermediate that feeds into the synthesis of glycerophospholipids for membrane expansion or…”
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Structure and mechanism of the human CTDNEP1-NEP1R1 membrane protein phosphatase complex necessary to maintain ER membrane morphology
Published in Proceedings of the National Academy of Sciences - PNAS (28-05-2024)“…C-terminal Domain Nuclear Envelope Phosphatase 1 (CTDNEP1) is a noncanonical protein serine/threonine phosphatase that has a conserved role in regulating ER…”
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