Linkage disequilibrium patterns and genetic structure of Amerindian and non-Amerindian Brazilian populations revealed by long-range X-STR markers

The extent of X‐chromosome linkage disequilibrium (LD) was studied in a southern Brazilian population, and in a pool of samples from Amerindian populations. For this purpose, 11 microsatellites, located mostly in a Xq region comprising ∼86 Mb was investigated. The lower Amerindian gene diversity ass...

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Bibliographic Details
Published in:	American journal of physical anthropology Vol. 139; no. 3; pp. 404 - 412
Main Authors:	Leite, Fabio P.N., Santos, Sidney E.B., Rodríguez, Elzemar M.R., Callegari-Jacques, Sidia M., Demarchi, Dario A., Tsuneto, Luiza T., Petzl-Erler, M. Luiza, Salzano, Francisco M., Hutz, Mara H.
Format:	Journal Article
Language:	English
Published:	Hoboken Wiley Subscription Services, Inc., A Wiley Company 01-07-2009 Wiley-Liss
Subjects:	Analysis of Variance Ancestry Biological anthropology Brazil Chromosomes, Human, X - genetics DNA Ethnology Gene Frequency Genetic Variation Genetics, Population Human ecology, environment Human genetics Human origins Humans Indians, South American - genetics Linkage Disequilibrium Male Microsatellite Repeats - genetics Migration research Morphological source materials Native Americans Physical anthropology Physical anthropology, ethnobiology Population population diversity South America South Amerindians X-chromosome microsatellites South America Brazil Amerindian X-chromosome microsatellites Statistical analysis population diversity Brazil Native Americans Afro-Brazilian European Structure Human diversity Population genetics linkage disequilibrium
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Summary:	The extent of X‐chromosome linkage disequilibrium (LD) was studied in a southern Brazilian population, and in a pool of samples from Amerindian populations. For this purpose, 11 microsatellites, located mostly in a Xq region comprising ∼86 Mb was investigated. The lower Amerindian gene diversity associated with significant differences between the populations studied indicated population structure as the main cause for the higher LD values in the Amerindian pool. On the other hand, the LD levels of the non‐Amerindian Brazilian sample, although less extensive than that of the Amerindians, were probably determined by admixture events. Our results indicated that different demographic histories have significant effects on LD levels of human populations, and provide a first approach to the X‐chromosome ancestry of Amerindian and non‐Amerindian Brazilian populations, being valuable for future studies involving mapping and population genetic studies. Am J Phys Anthropol 2009. © 2009 Wiley‐Liss, Inc.
Bibliography:	Secretaria Nacional de Segurança Pública Programa de Apoio a Grupos de Excelência Conselho Nacional de Desenvolvimento Científico e Tecnológico ark:/67375/WNG-C3146M38-1 Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul Instituto Geral de Perícias do Rio Grande do Sul Institutos do Milênio istex:089C533BD595D2F90F436ABBA1CFBB521DE93330 ArticleID:AJPA20998 ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Article-1 ObjectType-Feature-2
ISSN:	0002-9483 1096-8644
DOI:	10.1002/ajpa.20998