Search Results - "Rodman, John H"

Simultaneous measurement of intracellular triphosphate metabolites of zidovudine, lamivudine and abacavir (carbovir) in human peripheral blood mononuclear cells by combined anion exchange solid phase extraction and LC–MS/MS by Robbins, Brian L., Poston, Philip A., Neal, Erin F., Slaughter, Clive, Rodman, John H.

“…All nucleoside reverse transcriptase inhibitors (NRTI) must first be metabolized to their triphosphate forms in order to be active against HIV. Zidovudine…”
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Model for Intracellular Lamivudine Metabolism in Peripheral Blood Mononuclear Cells Ex Vivo and in Human Immunodeficiency Virus Type 1-Infected Adolescents by ZEXUN ZHOU, RODMAN, John H, FLYNN, Patricia M, ROBBINS, Brian L, WILCOX, Carrie K, D'ARGENIO, David Z

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Systemic Pharmacokinetics and Cellular Pharmacology of Zidovudine in Human Immunodeficiency Virus Type 1—Infected Women and Newborn Infants by Rodman, John H., Flynn, Patricia M., Robbins, Brian, Jimenez, Eleanor, Bardeguez, Arlene D., Rodriguez, Jose F., Blanchard, Suzette, Fridland, Arnold

“…Systemic and intracellular pharmacokinetics of zidovudine were determined for 28 human immunodeficiency virus type 1—infected pregnant women and their newborn…”
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Pharmacokinetics, safety and efficacy of lopinavir/ritonavir in infants less than 6 months of age : 24 week results by CHADWICK, Ellen G, CAPPARELLI, Edmund V, HUGHES, Michael, YOGEV, Ram, PINTO, Jorge A, ROBBINS, Brian, RODMAN, John H, JIE CHEN, PALUMBO, Paul, SERCHUCK, Leslie, SMITH, Elizabeth

“…To investigate pharmacokinetics, safety and efficacy of lopinavir/ritonavir (LPV/r)-based therapy in HIV-1-infected infants 6 weeks to 6 months of age. A…”
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Conventional Compared with Individualized Chemotherapy for Childhood Acute Lymphoblastic Leukemia by Evans, William E, Relling, Mary V, Rodman, John H, Crom, William R, Boyett, James M, Pui, Ching-Hon

“…Childhood acute lymphoblastic leukemia is curable in approximately 70 percent of children. 1 , 2 Many of the children who are not cured have presenting…”
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Single-Dose Pharmacokinetics and Safety of the Oral Antiviral Compound Adefovir Dipivoxil in Children Infected with Human Immunodeficiency Virus Type 1 by HUGHES, W. T, SHENEP, J. L, ZIMMER, B, BURCHETT, S, READ, J. S, RODMAN, J. H, FRIDLAND, A, WILLOUGHBY, R, BLANCHARD, S, PURDUE, L, COAKLEY, D. F, CUNDY, K. C, CULNANE, M

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Ritonavir-Based Highly Active Antiretroviral Therapy in Human Immunodeficiency Virus Type 1-Infected Infants Younger Than 24 Months of Age by Gould Chadwick, Ellen, Rodman, John H, Britto, Paula, Powell, Christine, Palumbo, Paul, Luzuriaga, Katherine, Hughes, Michael, Abrams, Elaine J, Flynn, Patricia M, Borkowsky, William, Yogev, Ram

“…BACKGROUND:Few data are available regarding clinical outcomes or dosing requirements for the protease inhibitor ritonavir in human immunodeficiency virus…”
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Abacavir and Metabolite Pharmacokinetics in HIV-1-Infected Children and Adolescents by Cross, Shane J, Rodman, John H, Lindsey, Jane C, Robbins, Brian L, Rose, Charles H, Yuen, Geoffrey J, DʼAngelo, Lawrence J

“…OBJECTIVES:Abacavir (ABC) oral clearance, adjusted for body size, is approximately 2 times higher for children than adults with a corresponding difference in…”
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Metabolism of Tenofovir and Didanosine in Quiescent or Stimulated Human Peripheral Blood Mononuclear Cells by Robbins, Brian L., Wilcox, Carrie K., Fridland, Arnold, Rodman, John H.

“…Objective. As tenofovir disoproxil fumarate substantially increases plasma concentrations of didanosine in patients with human immunodeficiency virus‐1…”
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Opportunities for integration of pharmacokinetics, pharmacodynamics, and toxicokinetics in rational drug development by Peck, C C, Barr, W H, Benet, L Z, Collins, J, Desjardins, R E, Furst, D E, Harter, J G, Levy, G, Ludden, T, Rodman, J H

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A Systemic and Cellular Model for Zidovudine Plasma Concentrations and Intracellular Phosphorylation in Patients by Rodman, John H., Robbins, Brian, Flynn, Patricia M., Fridland, Arnold

“…In a pharmacokinetic model for the systemic and cellular disposition of zidovudine in patients, serial measurements of plasma zidovudine and intracellular…”
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A Randomized Study of Outpatient Treatment with Ceftriaxone for Selected Febrile Children with Sickle Cell Disease by Wilimas, Judith A, Flynn, Patricia M, Harris, Sylvia, Day, Sara W, Smith, Ralph, Chesney, P. Joan, Rodman, John H, Eguiguren, Jose M, Fairclough, Diane L, Wang, Winfred C

“…Despite the use of pneumococcal vaccine and prophylactic oral penicillin, septicemia due to infection with Streptococcus pneumoniae remains a major cause of…”
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The pharmacokinetics of high-dose carboplatin in pediatric patients with cancer by Madden, T, Sunderland, M, Santana, V M, Rodman, J H

“…Carboplatin disposition was studied in 18 pediatric patients with cancer over a dosage range of 400 to 700 mg/m2 given on an alternate-day schedule (total…”
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Phase I study of escalating targeted doses of carboplatin combined with ifosfamide and etoposide in treatment of newly diagnosed pediatric solid tumors by Marina, N M, Rodman, J H, Murry, D J, Shema, S J, Bowman, L C, Jones, D P, Furman, W, Meyer, W H, Pratt, C B

“…The combination of carboplatin, ifosfamide, and etoposide has shown promising activity in a variety of relapsed childhood solid tumors but has not been studied…”
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Pharmacokinetics and acute renal effects of continuously infused carboplatin by Murry, D J, Sandlund, J T, Stricklin, L M, Rodman, J H

“…Carboplatin was given as a 24-hour infusion at high doses to pediatric patients with cancer (n = 11) and pharmacokinetic parameters and renal effects were…”
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Phenytoin pharmacokinetics in critically ill trauma patients by Boucher, B A, Rodman, J H, Jaresko, G S, Rasmussen, S N, Watridge, C B, Fabian, T C

“…Preliminary data have suggested that phenytoin systemic clearance may increase during initial therapy in critically ill patients. The objectives for this study…”
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Pharmacokinetics of continuous infusion of methotrexate and teniposide in pediatric cancer patients by RODMAN, J. H, SUNDERLAND, M, KAVANAGH, R. L, OCHS, J, YALOWICH, J, EVANS, W. E, RIVERA, G. K

“…Laboratory studies have demonstrated the ability of teniposide to markedly enhance the intracellular accumulation of methotrexate suggesting that combination…”
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Phase I clinical trial of orally administered 4-demethoxydaunorubicin (idarubicin) with pharmacokinetic and in vitro drug sensitivity testing in children with refractory leukemia by Pui, C H, de Graaf, S S, Dow, L W, Rodman, J H, Evans, W E, Alpert, B S, Murphy, S B

“…Fifteen children with acute leukemia in relapse, refractory to conventional therapy, were treated with idarubicin administered orally for 3 consecutive days in…”
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Patient characteristics associated with high-risk methotrexate concentrations and toxicity by Relling, M V, Fairclough, D, Ayers, D, Crom, W R, Rodman, J H, Pui, C H, Evans, W E

“…Following high-dose methotrexate (HD-MTX) treatment, delayed MTX elimination is an important problem because it necessitates increased leucovorin rescue and…”
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Design of antiretroviral clinical trials for HIV-1 infected pregnant women and their newborn infants by Rodman, John H.

“…Antiretroviral therapy has been highly successful in reducing mother to child transmission of human immunodeficiency virus-1 infection in pregnant women…”
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