Search Results - "Rodman, David"

Effect of an intravitreal antisense oligonucleotide on vision in Leber congenital amaurosis due to a photoreceptor cilium defect by Cideciyan, Artur V., Jacobson, Samuel G., Drack, Arlene V., Ho, Allen C., Charng, Jason, Garafalo, Alexandra V., Roman, Alejandro J., Sumaroka, Alexander, Han, Ian C., Hochstedler, Maria D., Pfeifer, Wanda L., Sohn, Elliott H., Taiel, Magali, Schwartz, Michael R., Biasutto, Patricia, Wit, Wilma de, Cheetham, Michael E., Adamson, Peter, Rodman, David M., Platenburg, Gerard, Tome, Maria D., Balikova, Irina, Nerinckx, Fanny, Zaeytijd, Julie De, Van Cauwenbergh, Caroline, Leroy, Bart P., Russell, Stephen R.

“…Photoreceptor ciliopathies constitute the most common molecular mechanism of the childhood blindness Leber congenital amaurosis. Ten patients with Leber…”
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A CFTR corrector (lumacaftor) and a CFTR potentiator (ivacaftor) for treatment of patients with cystic fibrosis who have a phe508del CFTR mutation: a phase 2 randomised controlled trial by Boyle, Michael P, Dr, Bell, Scott C, Prof, Konstan, Michael W, Prof, McColley, Susanna A, Prof, Rowe, Steven M, MD, Rietschel, Ernst, Prof, Huang, Xiaohong, PhD, Waltz, David, MD, Patel, Naimish R, MD, Rodman, David, MD

“…Summary Background The phe508del CFTR mutation causes cystic fibrosis by limiting the amount of CFTR protein that reaches the epithelial cell surface. We…”
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Bone morphogenetic protein receptor II regulates pulmonary artery endothelial cell barrier function by Burton, Victoria J., Ciuclan, Loredana I., Holmes, Alan M., Rodman, David M., Walker, Christoph, Budd, David C.

“…Mutations in bone morphogenetic protein receptor II (BMPR-II) underlie most heritable cases of pulmonary arterial hypertension (PAH). However, less than half…”
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Cystic fibrosis adult care: consensus conference report by Yankaskas, James R, Marshall, Bruce C, Sufian, Beth, Simon, Richard H, Rodman, David

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Interaction of interleukin-6 and the BMP pathway in pulmonary smooth muscle by Hagen, Moira, Fagan, Karen, Steudel, Wolfgang, Carr, Michelle, Lane, Kirk, Rodman, David M, West, James

“…The majority of familial pulmonary arterial hypertension (PAH) cases are caused by mutations in the type 2 bone morphogenetic protein receptor (BMPR2)…”
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First‐in‐human study evaluating safety, pharmacokinetics, and pharmacodynamics of lorundrostat, a novel and highly selective aldosterone synthase inhibitor by Shimizu, Hidetoshi, Tortorici, Michael A., Ohta, Yoshiyasu, Ogawa, Kei, Rahman, Sheikh Mohammed Ashfaq, Fujii, Aya, Hiraga, Yuki, Kawai, Mizue, Sugimoto‐Kawabata, Kanami, Iersel, Mattheus (Thijs), Lier, Jan Jaap, Djedjos, Stephen, Slingsby, B. T., Rodman, David M.

“…Dysregulation of the mineralocorticoid hormone aldosterone is an increasingly prevalent cause of hypertension. Aldosterone synthase (CYP11B2) shares 93%…”
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Pulmonary Hypertension in Transgenic Mice Expressing a Dominant-Negative BMPRII Gene in Smooth Muscle by West, James, Fagan, Karen, Steudel, Wolfgang, Fouty, Brian, Lane, Kirk, Harral, Julie, Hoedt-Miller, Marloes, Tada, Yuji, Ozimek, John, Tuder, Rubin, Rodman, David M

“…ABSTRACT—Bone morphogenetic peptides (BMPs), a family of cytokines critical to normal development, were recently implicated in the pathogenesis of familial…”
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The effects of an anti–IL-13 mAb on cytokine levels and nasal symptoms following nasal allergen challenge by Nicholson, Grant C., BSc, Kariyawasam, Harsha H., MBBS, PhD, Tan, Andrew J., MSc, Hohlfeld, Jens M., MD, Quinn, Deborah, MD, Walker, Christoph, PhD, Rodman, David, MD, Westwick, John, PhD, Jurcevic, Stipo, PhD, Kon, Onn Min, MD, Barnes, Peter J., FMedSci, FRS, Krug, Norbert, MD, Hansel, Trevor T., MBBCh, PhD

“…Background IL-13 is a key TH 2 cytokine that is implicated in allergic responses. Objective We evaluated the effects of an anti–IL-13–blocking antibody…”
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Transgenic Mice Overexpressing the 5-Hydroxytryptamine Transporter Gene in Smooth Muscle Develop Pulmonary Hypertension by Guignabert, Christophe, Izikki, Mohamed, Tu, Ly Ieng, Li, Zhenlin, Zadigue, Patricia, Barlier-Mur, Anne-Marie, Hanoun, Naïma, Rodman, David, Hamon, Michel, Adnot, Serge, Eddahibi, Saadia

“…One intrinsic abnormality of pulmonary artery smooth muscle cells (PA-SMCs) in human idiopathic pulmonary hypertension (iPH) is an exaggerated proliferative…”
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Role of endothelin-1 in lung disease by Fagan, K A, McMurtry, I F, Rodman, D M

“…Endothelin-1 (ET-1) is a 21 amino acid peptide with diverse biological activity that has been implicated in numerous diseases. ET-1 is a potent mitogen…”
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Low-Voltage-Activated (T-Type) Calcium Channels Control Proliferation of Human Pulmonary Artery Myocytes by Rodman, David M, Reese, Katherine, Harral, Julie, Fouty, Brian, Wu, Songwei, West, James, Hoedt-Miller, Marloes, Tada, Yuji, Li, Kai-Xun, Cool, Carlyne, Fagan, Karen, Cribbs, Leanne

“…While Ca influx is essential for activation of the cell cycle machinery, the processes that regulate Ca influx in this context have not been fully elucidated…”
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BMP signaling controls PASMC KV channel expression in vitro and in vivo by Young, Katharine A, Ivester, Charles, West, James, Carr, Michelle, Rodman, David M

“…Bone morphogenetic proteins (BMPs) have been implicated in the pathogenesis of familial pulmonary arterial hypertension. The type 2 receptor (BMPR2) is…”
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Late Diagnosis Defines a Unique Population of Long-term Survivors of Cystic Fibrosis by Rodman, David M, Polis, Jillian M, Heltshe, Sonya L, Sontag, Marci K, Chacon, Cathy, Rodman, Rachel V, Brayshaw, Sara J, Huitt, Gwen A, Iseman, Michael D, Saavedra, Milene T, Taussig, Lynn M, Wagener, Jeffrey S, Accurso, Frank J, Nick, Jerry A

“…Although the median survival for patients with cystic fibrosis (CF) is 32.9 years, a small group of patients live much longer. We analyzed the genotype and…”
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Pulmonary Fibrosis and Chronic Lung Inflammation in ET-1 Transgenic Mice by Hocher, Berthold, Schwarz, Anja, Fagan, Karen A, Thone-Reineke, Christa, El-Hag, Karim, Kusserow, Heike, Elitok, Saban, Bauer, Christian, Neumayer, Hans-H, Rodman, David M, Theuring, Franz

“…The pulmonary endothelin (ET) system has been implicated in the pathogenesis of chronic lung diseases such as pulmonary hypertension, asthma, chronic…”
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Abstract 17143: Lorundrostat for Treatment of Obesity-Related, Aldosterone-Dependent Hypertension - An Endotype-Specific, Targeted Approach to the Treatment of Uncontrolled Hypertension by Rodman, David, Cizman, Borut

“…Abstract only Hyperaldosteronism manifests as low renin hypertension (HTN) with endothelial dysfunction and vascular fibrosis. In the aging vasculature, these…”
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Effect of the S‐nitrosoglutathione reductase inhibitor N6022 on bronchial hyperreactivity in asthma by Que, Loretta G., Yang, Zhonghui, Lugogo, Njira L., Katial, Rohit K., Shoemaker, Steven A., Troha, Janice M., Rodman, David M., Tighe, Robert M., Kraft, Monica

“…Rationale Patients with asthma demonstrate depletion of the endogenous bronchodilator GSNO and upregulation of GSNOR. Objectives An exploratory proof of…”
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Localization of Endothelial Nitric-oxide Synthase Phosphorylated on Serine 1179 and Nitric Oxide in Golgi and Plasma Membrane Defines the Existence of Two Pools of Active Enzyme by Fulton, David, Fontana, Jason, Sowa, Grzegorz, Gratton, Jean-Philippe, Lin, Michelle, Li, Kai-Xun, Michell, Belinda, Kemp, Bruce E., Rodman, David, Sessa, William C.

“…The subcellular localization of endothelial nitric-oxide synthase (eNOS) is critical for optimal coupling of extracellular stimulation to nitric oxide…”
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Second-Strand Genome Conversion of Adeno-Associated Virus Type 2 (AAV-2) and AAV-5 Is Not Rate Limiting following Apical Infection of Polarized Human Airway Epithelia by Ding, Wei, Yan, Ziying, Zak, Roman, Saavedra, Milene, Rodman, David M, Engelhardt, John F

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Upregulation of nitric oxide synthase in mice with severe hypoxia-induced pulmonary hypertension by Fagan, K A, Morrissey, B, Fouty, B W, Sato, K, Harral, J W, Morris, Jr, K G, Hoedt-Miller, M, Vidmar, S, McMurtry, I F, Rodman, D M

“…The importance of nitric oxide (NO) in hypoxic pulmonary hypertension has been demonstrated using nitric oxide synthase (NOS) knockout mice. In that model NO…”
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Pulmonary arterial hypertension : Future directions report of a national heart, lung and blood institute/office of rare diseases workshop by NEWMAN, John H, FANBURG, Barry L, MORSE, Jane H, NICHOLS, William C, RABINOVITCH, Marlene, RODMAN, David M, STEVENS, Troy, TUDER, Rubin M, VOELKEL, Norbert F, GAIL, Dorothy B, ARCHER, Stephen L, BADESCH, David B, BARST, Robyn J, GARCIA, Joe G. N, KAO, Peter N, KNOWLES, James A, LOYD, James E, MCGOON, Michael D

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