Quantification of mast cells in different stages of human periodontal disease

Objective and methods: Among the cells involved in immune and inflammatory responses in periodontal disease, mast cells have been shown to be capable of generating a large number of biologically active substances. The present study was undertaken to identify and quantify the presence of mast cells...

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Bibliographic Details
Published in:	Oral diseases Vol. 11; no. 4; pp. 249 - 254
Main Authors:	Batista, AC, Rodini, CO, Lara, VS
Format:	Journal Article
Language:	English
Published:	Oxford, UK Munksgaard International Publishers 01-07-2005
Subjects:	Analysis of Variance Cell Count Chronic Disease Dentistry Gingivitis - immunology Gingivitis - pathology Histocytochemistry Humans Immunoenzyme Techniques lymphocytes Mast Cells periodontal disease Periodontitis - immunology Periodontitis - pathology Staining and Labeling - methods
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Summary:	Objective and methods: Among the cells involved in immune and inflammatory responses in periodontal disease, mast cells have been shown to be capable of generating a large number of biologically active substances. The present study was undertaken to identify and quantify the presence of mast cells in different stages of human periodontal disease using histochemical (toluidine blue) and immunohistochemical (tryptase‐positive mast cells) techniques. Results: Mast cell densities (cells per mm2) were significantly increased in chronic periodontitis/gingivitis lesions compared with clinically healthy gingival tissues (Health) uniquely by immunohistochemical technique. Interestingly, mast cells were distributed specially in close apposition to mononuclear cells. Conclusions: In human periodontal disease there is an increase in the number of mast cells that may be participating either in the destructive events or in the defense mechanism of periodontal disease via secretion of cytokines, including perpetuation of the Th2 response, and cellular migration and healing processes.
Bibliography:	ark:/67375/WNG-Q7FZTS59-5 istex:E9BBCA756F1F5CC74601F9673E99E2955A9DEF18 ArticleID:ODI1113 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1354-523X 1601-0825
DOI:	10.1111/j.1601-0825.2005.01113.x