Search Results - "Rodin, Sergei N"

On origin of genetic code and tRNA before translation by Rodin, Andrei S, Szathmáry, Eörs, Rodin, Sergei N

“…Synthesis of proteins is based on the genetic code - a nearly universal assignment of codons to amino acids (aas). A major challenge to the understanding of…”
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CpG island clusters and pro-epigenetic selection for CpGs in protein-coding exons of HOX and other transcription factors by Branciamore, Sergio, Chen, Zhao-Xia, Riggs, Arthur D., Rodin, Sergei N.

“…CpG dinucleotides contribute to epigenetic mechanisms by being the only site for DNA methylation in mammalian somatic cells. They are also mutation hotspots…”
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Enhanced evolution by stochastically variable modification of epigenetic marks in the early embryo by Branciamore, Sergio, Rodin, Andrei S., Riggs, Arthur D., Rodin, Sergei N.

“…Evolution by gene duplication is generally accepted as one of the crucial driving forces for the gain of new complexity and functions, but the formation of…”
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Epigenetic silencing may aid evolution by gene duplication by Rodin, Sergei N, Riggs, Arthur D

“…Gene duplication is commonly regarded as the main evolutionary path toward the gain of a new function. However, even with gene duplication, there is a…”
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One ancestor for two codes viewed from the perspective of two complementary modes of tRNA aminoacylation by Rodin, Andrei S, Szathmáry, Eörs, Rodin, Sergei N

“…The genetic code is brought into action by 20 aminoacyl-tRNA synthetases. These enzymes are evenly divided into two classes (I and II) that recognize tRNAs…”
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Human Lung Cancer and p53: The Interplay between Mutagenesis and Selection by Rodin, Sergei N., Rodin, Andrew S.

“…It is an almost consensus opinion that the major carcinogenic risk of tobacco smoke is in its direct mutagenic action on DNA of cancer-related genes. The key…”
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Origin of the genetic code: first aminoacyl-tRNA synthetases could replace isofunctional ribozymes when only the second base of codons was established by Rodin, Sergei N, Rodin, Andrei S

“…Analysis of the updated compilation of more than 8,000 tRNA gene sequences confirmed our previously reported finding that in pairs of consensus tRNAs with…”
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Position-associated GC asymmetry of gene duplicates by Rodin, Sergei N, Parkhomchuk, Dmitri V

“…It is well known that repositioning of a gene often exerts a strong impact on its own expression and whole development. Here we report the results of…”
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Four Primordial Modes of tRNA-Synthetase Recognition, Determined by the (G,C) Operational Code by Rodin, Sergei N., Ohno, Susumu

“…In distinction to single-stranded anticodons built of G, C, A, and U bases, their presumable double-stranded precursors at the first three positions of the…”
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Strand Asymmetry of CpG Transitions as Indicator of G1 Phase-Dependent Origin of Multiple Tumorigenic p53 Mutations in Stem Cells by Rodin, Sergei N., Rodin, Andrew S.

“…In dividing cells, expression of mutations is DNA strand symmetric. Of all mutations originating de novo in nondividing cells, only those in the transcribed…”
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On Primordial Sense-Antisense Coding by Rodin, Andrei S, Rodin, Sergei N, Carter, Charles W. Jr

“…The genetic code is implemented by aminoacyl-tRNA synthetases (aaRS). These 20 enzymes are divided into two classes that, despite performing same functions,…”
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Origins and selection of p53 mutations in lung carcinogenesis by Rodin, Sergei N, Rodin, Andrei S

“…Molecular epidemiologists usually consider the spectrum of p53 mutations found in human tumors to be a signature of the corresponding environmental…”
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Partitioning of aminoacyl-tRNA synthetases in two classes could have been encoded in a strand-symmetric RNA world by Rodin, Sergei N, Rodin, Andrei S

“…The "chicken-or-egg" dilemma dictates that archaic tRNAs be aminoacylated by ribozymic aminoacyl-tRNA synthetases, rAARSs, with protein synthetases (pAARSs)…”
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Translation of Both Complementary Strands Might Govern Early Evolution of the Genetic Code by Rodin, Andrei S., Rodin, Sergei N.

“…The updated structural and phylogenetic analyses of tRNA pairs with complementary anticodons provide independent support for our earlier finding, namely that…”
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Repositioning-dependent fate of duplicate genes by Rodin, Sergei N, Parkhomchuk, Dmitri V, Rodin, Andrei S, Holmquist, Gerald P, Riggs, Arthur D

“…Gene duplication is the main source of evolutionary novelties. However, the problem with duplicates is that the purifying selection overlooks deleterious…”
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On the origin of p53 G:C --> T:A transversions in lung cancers by Rodin, Sergei N, Rodin, Andrew S

“…The high frequency of G-->T transversions in the p53 gene is a distinctive feature of lung cancer patients with a smoking history and is commonly believed to…”
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On the excess of G --> T transversions in the p53 gene in lung cancer cell lines. Reply to Pfeifer and Hainaut by Rodin, Sergei N, Rodin, Andrei S

“…Our recent retrospective analysis of the lung cancer-associated p53 mutation data [Mutat. Res. 508 (2002) 1] showed the possibility of (i) inhibiting action of…”
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Fifth International Conference on Bioinformatics of Genome Regulation and Structure-BGRS'2006 by Rodin, Sergei N., Kolchanov, Nikolay A.

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On the origin of p53 G:C → T:A transversions in lung cancers by RODIN, Sergei N, RODIN, Andrew S

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Strand asymmetry of CpG transitions as indicator of G 1 phase-dependent origin of multiple tumorigenic p53 mutations in stem cells by Rodin, Sergei N., Rodin, Andrew S.

“…In dividing cells, expression of mutations is DNA strand symmetric. Of all mutations originating de novo in nondividing cells, only those in the transcribed…”
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