Search Results - "Rodgers, Karla"

Riches in RAGs: Revealing the V(D)J Recombinase through High-Resolution Structures by Rodgers, Karla K.

“…Development of the adaptive immune system is dependent on V(D)J recombination, which forms functional antigen receptor genes through rearrangement of component…”
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An updated definition of V(D)J recombination signal sequences revealed by high-throughput recombination assays by Hoolehan, Walker, Harris, Justin C, Byrum, Jennifer N, Simpson, Destiny A, Rodgers, Karla K

“…In the adaptive immune system, V(D)J recombination initiates the production of a diverse antigen receptor repertoire in developing B and T cells. Recombination…”
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RAG2 localization and dynamics in the pre-B cell nucleus by Rodgers, William, Byrum, Jennifer N, Simpson, Destiny A, Hoolehan, Walker, Rodgers, Karla K

“…RAG2 of the V(D)J recombinase is essential for lymphocyte development. Within the RAG2 noncore region is a plant homeodomain (PHD) that interacts with the…”
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Molecular Mechanisms of DNA Sequence Selectivity in V(D)J Recombination by Hoolehan, Walker, Harris, Justin C., Rodgers, Karla K.

“…Antigen receptor (AgR) diversity is central to the ability of adaptive immunity in jawed vertebrates to protect against pathogenic agents. The production of…”
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Full length RAG2 expression enhances the DNA damage response in pre-B cells by Byrum, Jennifer N., Hoolehan, Walker E., Simpson, Destiny A., Rodgers, William, Rodgers, Karla K.

“…V(D)J recombination by the RAG1 and RAG2 protein complex in developing lymphocytes includes DNA double strand break (DSB) intermediates. RAG2 undergoes export…”
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A Unique Loop Structure in Oncostatin M Determines Binding Affinity toward Oncostatin M Receptor and Leukemia Inhibitory Factor Receptor by Chollangi, Srinivas, Mather, Timothy, Rodgers, Karla K., Ash, John D.

“…Oncostatin M (OSM) and leukemia inhibitory factor are pleiotropic cytokines that belong to the interleukin-6 (IL-6) family. These cytokines play a crucial role…”
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Lack of activity of HIV-1 integrase strand-transfer inhibitors on recombinase activating gene (RAG) activity at clinically relevant concentrations by Demirdjian, Sally, Duong, Vincent N., Byrum, Jennifer N., Nayak, Arabinda, McKinney, Cooper B., Perry, Jason K., Callebaut, Christian, Rodgers, Karla K., Falkard, Brie, Feng, Joy Y.

“…Human immunodeficiency virus 1 (HIV-1) infection remains a global health concern, with nearly 30 million people on antiretroviral (ARV) treatment. Integrase…”
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Binding to lipid membrane induces conformational changes in RPE65: implications for its isomerohydrolase activity by Nikolaeva, Olga, Moiseyev, Gennadiy, Rodgers, Karla K, Ma, Jian-Xing

“…The visual cycle is a multi-step pathway to recycle 11-cis retinal, the chromophore for both rod and cone visual pigments. The isomerohydrolase RPE65, a…”
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Effects of SPA4 peptide on lipopolysaccharide‐disrupted lung epithelial barrier, injury, and function in a human cell system and mouse model of lung injury by Chowdhury, Asif Alam, Godbole, Nachiket M., Chataut, Neha, Kosanke, Stanley, Rodgers, Karla, Awasthi, Shanjana

“…Disrupted epithelial barrier, fluid accumulation, inflammation, and compromised physiology are hallmarks of lung injury. Here we investigated the structural…”
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An interdomain boundary in RAG1 facilitates cooperative binding to RAG2 in formation of the V(D)J recombinase complex by Byrum, Jennifer N, Zhao, Shuying, Rahman, Negar S, Gwyn, Lori M, Rodgers, William, Rodgers, Karla K

“…V(D)J recombination assembles functional antigen receptor genes during lymphocyte development. Formation of the recombination complex containing the…”
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Mechanism of Anti-Inflammatory Activity of TLR4-Interacting SPA4 Peptide by Awasthi, Shanjana, Kumar, Gaurav, Ramani, Vijay, Awasthi, Vibhudutta, Rodgers, Karla K, Xie, Jun, Beierle, Jacob, Kyere-Davies, Gertrude, Singh, Bhupinder, Rahman, Negar, Chowdhury, Asif Alam, Chataut, Neha

“…The TLR4-interacting SPA4 peptide suppresses inflammation. We assessed the structural and physicochemical properties and binding of SPA4 peptide to TLR4-MD2…”
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Glycosylation of Skp1 Affects Its Conformation and Promotes Binding to a Model F‑Box Protein by Sheikh, M. Osman, Schafer, Christopher M, Powell, John T, Rodgers, Karla K, Mooers, Blaine H. M, West, Christopher M

“…In the social amoeba Dictyostelium, Skp1 is hydroxylated on proline 143 and further modified by three cytosolic glycosyltransferases to yield an O-linked…”
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Structural characterization of the second intra‐discal loop of the photoreceptor tetraspanin RDS by Chakraborty, Dibyendu, Rodgers, Karla K., Conley, Shannon M., Naash, Muna I.

“…Vertebrate photoreceptors contain a unique tetraspanin protein known as ‘retinal degeneration slow’ (RDS). Mutations in the RDS gene have been identified in a…”
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Spatio-temporal regulation of RAG2 following genotoxic stress by Rodgers, William, Byrum, Jennifer N., Sapkota, Hem, Rahman, Negar S., Cail, Robert C., Zhao, Shuying, Schatz, David G., Rodgers, Karla K.

“…•Genotoxic stress triggers nuclear export and centrosome targeting of RAG2.•Inhibitors to DNA damage response factors blocked redistribution of RAG2.•Following…”
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The B3 Subunit of the Cone Cyclic Nucleotide-gated Channel Regulates the Light Responses of Cones and Contributes to the Channel Structural Flexibility by Ding, Xi-Qin, Thapa, Arjun, Ma, Hongwei, Xu, Jianhua, Elliott, Michael H., Rodgers, Karla K., Smith, Marci L., Wang, Jin-Shan, Pittler, Steven J., Kefalov, Vladimir J.

“…Cone photoreceptor cyclic nucleotide-gated (CNG) channels play a pivotal role in cone phototransduction, which is a process essential for daylight vision,…”
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Elucidating the domain architecture and functions of non-core RAG1: the capacity of a non-core zinc-binding domain to function in nuclear import and nucleic acid binding by Arbuckle, Janeen L, Rahman, Negar S, Zhao, Shuying, Rodgers, William, Rodgers, Karla K

“…The repertoire of the antigen-binding receptors originates from the rearrangement of immunoglobulin and T-cell receptor genetic loci in a process known as…”
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A Non-Sequence-Specific DNA Binding Mode of RAG1 Is Inhibited by RAG2 by Zhao, Shuying, Gwyn, Lori M., De, Pallabi, Rodgers, Karla K.

“…RAG1 and RAG2 proteins catalyze site-specific DNA cleavage reactions in V(D)J recombination, a process that assembles antigen receptor genes from component…”
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Putting the pieces together: identification and characterization of structural domains in the V(D)J recombination protein RAG1 by De, Pallabi, Rodgers, Karla K.

“…V(D)J recombination generates functional immunoglobulin and T‐cell receptor genes in developing lymphocytes. The recombination‐activating gene 1 (RAG1) and…”
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The Disease-Causing Mutations in the Carboxyl Terminus of the Cone Cyclic Nucleotide-Gated Channel CNGA3 Subunit Alter the Local Secondary Structure and Interfere with the Channel Active Conformational Change by Matveev, Alexander V, Fitzgerald, J. Browning, Xu, Jianhua, Malykhina, Anna P, Rodgers, Karla K, Ding, Xi-Qin

“…The cone photoreceptor cyclic nucleotide-gated (CNG) channel plays a pivotal role in phototransducton. Mutations in the channel subunits are associated with…”
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Biochemical and Structural Characterization of the Interaction of Memapsin 2 (β-Secretase) Cytosolic Domain with the VHS Domain of GGA Proteins by He, Xiangyuan, Zhu, Guangyu, Koelsch, Gerald, Rodgers, Karla K, Zhang, Xuejun C, Tang, Jordan

“…Memapsin 2 (β-secretase) is a membrane-associated aspartic protease that initiates the hydrolysis of β-amyloid precursor protein (APP) leading to the…”
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