Search Results - "Rodgers, Jean"

Trypanosomiasis and the brain by Rodgers, Jean

“…Neurological involvement following trypanosome infection has been recognised for over a century. However, there are still many unanswered questions concerning…”
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Clinical and Neuropathogenetic Aspects of Human African Trypanosomiasis by Kennedy, Peter G E, Rodgers, Jean

“…Trypanosomiasis has been recognized as a scourge in sub-Saharan Africa for centuries. The disease, caused by protozoan parasites of the genus, is a major cause…”
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Serial magnetic resonance imaging of splenomegaly in the Trypanosoma brucei infected mouse by Paterson, Samantha, Holmes, William Matthew, Rodgers, Jean

“…Splenomegaly, an enlargement of the spleen, is a known clinical sign of the parasitic disease, human African trypanosomiasis. This study follows the…”
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Application of diffusion weighted multiple boli ASL to a murine model of human African trypanosomiasis by Paterson, Samantha, Vallatos, Antoine, Rodgers, Jean, Holmes, William M.

“…Human African Trypanosomiasis (HAT) is a parasitic disease originating in sub-Saharan Africa. There is limited information about the changes in the blood brain…”
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Microarray profiling predicts early neurological and immune phenotypic traits in advance of CNS disease during disease progression in Trypanosoma. b. brucei infected CD1 mouse brains by Montague, Paul, Bradley, Barbara, Rodgers, Jean, Kennedy, Peter G E

“…Human African trypanosomiasis (HAT), also known as sleeping sickness, is a major cause of mortality and morbidity in sub-Saharan Africa. We hypothesised that…”
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Comparison of loop-mediated isothermal amplification (LAMP) and PCR for the diagnosis of infection with Trypanosoma brucei ssp. in equids in The Gambia by Gummery, Lauren, Jallow, Saloum, Raftery, Alexandra G, Bennet, Euan, Rodgers, Jean, Sutton, David G. M

“…Introduction Infection of equids with Trypanosoma brucei (T. brucei) ssp. is of socioeconomic importance across sub-Saharan Africa as the disease often…”
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Safety and efficacy of three trypanocides in confirmed field cases of trypanosomiasis in working equines in The Gambia: a prospective, randomised, non-inferiority trial by Raftery, Alexandra G, Jallow, Saloum, Rodgers, Jean, Sutton, David G M

“…Globally, working equines have a continued and growing socioeconomic role in supporting the livelihoods of between 300-600 million people in low income…”
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Trypanosoma brucei Invasion and T-Cell Infiltration of the Brain Parenchyma in Experimental Sleeping Sickness: Timing and Correlation with Functional Changes by Laperchia, Claudia, Palomba, Maria, Seke Etet, Paul F, Rodgers, Jean, Bradley, Barbara, Montague, Paul, Grassi-Zucconi, Gigliola, Kennedy, Peter G E, Bentivoglio, Marina

“…The timing of Trypanosoma brucei entry into the brain parenchyma to initiate the second, meningoencephalitic stage of human African trypanosomiasis or sleeping…”
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Intravital imaging of a massive lymphocyte response in the cortical dura of mice after peripheral infection by trypanosomes by Coles, Jonathan A, Myburgh, Elmarie, Ritchie, Ryan, Hamilton, Alana, Rodgers, Jean, Mottram, Jeremy C, Barrett, Michael P, Brewer, James M

“…Peripheral infection by Trypanosoma brucei, the protozoan responsible for sleeping sickness, activates lymphocytes, and, at later stages, causes…”
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Pentamidine movement across the murine blood-brain and blood-cerebrospinal fluid barriers: effect of trypanosome infection, combination therapy, P-glycoprotein, and multidrug resistance-associated protein by Sanderson, Lisa, Dogruel, Murat, Rodgers, Jean, De Koning, Harry Pieter, Thomas, Sarah Ann

“…During the first stage of human African trypanosomiasis (HAT), Trypanosoma brucei gambiense is found mainly in the blood, and pentamidine treatment is used…”
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Variation in disease phenotype is marked in equine trypanosomiasis by Raftery, Alexandra G, Jallow, Saloum, Coultous, Robert M, Rodgers, Jean, Sutton, David G M

“…Equine trypanosomiasis is a severe and prevalent disease that has the greatest impact globally upon working equids due to its distribution across lower income…”
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Expression of interferon-inducible chemokines and sleep/wake changes during early encephalitis in experimental African trypanosomiasis by Laperchia, Claudia, Tesoriero, Chiara, Seke-Etet, Paul F, La Verde, Valentina, Colavito, Valeria, Grassi-Zucconi, Gigliola, Rodgers, Jean, Montague, Paul, Kennedy, Peter G E, Bentivoglio, Marina

“…Human African trypanosomiasis or sleeping sickness, caused by the parasite Trypanosoma brucei, leads to neuroinflammation and characteristic sleep/wake…”
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In vivo imaging of trypanosome-brain interactions and development of a rapid screening test for drugs against CNS stage trypanosomiasis by Myburgh, Elmarie, Coles, Jonathan A, Ritchie, Ryan, Kennedy, Peter G E, McLatchie, Alex P, Rodgers, Jean, Taylor, Martin C, Barrett, Michael P, Brewer, James M, Mottram, Jeremy C

“…HUMAN AFRICAN TRYPANOSOMIASIS (HAT) MANIFESTS IN TWO STAGES OF DISEASE: firstly, haemolymphatic, and secondly, an encephalitic phase involving the central…”
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Melarsoprol cyclodextrin inclusion complexes as promising oral candidates for the treatment of human African trypanosomiasis by Rodgers, Jean, Jones, Amy, Gibaud, Stéphane, Bradley, Barbara, McCabe, Christopher, Barrett, Michael P, Gettinby, George, Kennedy, Peter G E

“…Human African trypanosomiasis (HAT), or sleeping sickness, results from infection with the protozoan parasites Trypanosoma brucei (T. b.) gambiense or T. b…”
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Magnetic Resonance Imaging to Assess Blood―Brain Barrier Damage in Murine Trypanosomiasis by RODGERS, Jean, MCCABE, Christopher, GETTINBY, George, BRADLEY, Barbara, CONDON, Barrie, KENNEDY, Peter G. E

“…The ability of trypanosomes to invade the brain and induce an inflammatory reaction is well-recognized. This study uses magnetic resonance imaging (MRI) in…”
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Kynurenine pathway metabolism following prenatal KMO inhibition and in Mecp2+/− mice, using liquid chromatography-tandem mass spectrometry by Forrest, Caroline M., Kennedy, Peter G.E., Rodgers, Jean, Dalton, R. Neil, Turner, Charles, Darlington, L. Gail, Cobb, Stuart R., Stone, Trevor W.

“…To quantify the full range of tryptophan metabolites along the kynurenine pathway, a liquid chromatography – tandem mass spectrometry method was developed and…”
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Central Nervous System Parasitosis and Neuroinflammation Ameliorated by Systemic IL-10 Administration in Trypanosoma brucei-Infected Mice by Rodgers, Jean, Bradley, Barbara, Kennedy, Peter G E, Sternberg, Jeremy M

“…Invasion of the central nervous system (CNS) by African trypanosomes represents a critical step in the development of human African trypanosomiasis. In both…”
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Translational Physiology of Anti-Müllerian Hormone: Clinical Applications in Female Fertility Preservation and Cancer Treatment by Rodgers, Rachael Jean, Abbott, Jason Anthony, Walters, Kirsty A, Ledger, William Leigh

“…Whilst the ability of AMH to induce the regression of the Müllerian ducts in the male fetus is well appreciated, AMH has additional biological actions in…”
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AFRICAN TRYPANOSOME INTERACTIONS WITH AN IN VITRO MODEL OF THE HUMAN BLOOD–BRAIN BARRIER by Grab, Dennis J, Nikolskaia, Olga, Kim, Yuri V, Lonsdale-Eccles, John D, Ito, Susumu, Hara, Tatsuru, Fukuma, Toshihide, Nyarko, Elvis, Kim, Kee Jun, Stins, Monique F, Delannoy, Michael J, Rodgers, Jean, Kim, Kwang Sik

“…The neurological manifestations of sleeping sickness in man are attributed to the penetration of the blood–brain barrier (BBB) and invasion of the central…”
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Combination chemotherapy with a substance P receptor antagonist (aprepitant) and melarsoprol in a mouse model of human African trypanosomiasis by Rodgers, Jean, Bradley, Barbara, Kennedy, Peter GE

“…Abstract Drug therapy for late-stage (encephalitic) human African trypanosomiasis (HAT) is currently very unsatisfactory with the most commonly used drug,…”
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