Search Results - "Rodgers, David W."

Structure of puromycin-sensitive aminopeptidase and polyglutamine binding by Madabushi, Sowmya, Chow, K Martin, Song, Eun Suk, Goswami, Anwesha, Hersh, Louis B, Rodgers, David W

“…Puromycin-sensitive aminopeptidase (E.C. 3.4.11.14, UniProt P55786), a zinc metallopeptidase belonging to the M1 family, degrades a number of bioactive…”
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Understanding Laccase–Ionic Liquid Interactions toward Biocatalytic Lignin Conversion in Aqueous Ionic Liquids by Stevens, Joseph C, Das, Lalitendu, Mobley, Justin K, Asare, Shardrack O, Lynn, Bert C, Rodgers, David W, Shi, Jian

“…Lignin is a crucial component of plant matter; however, it is also largely responsible for the recalcitrance of lignocellulosic biomass when subjected to…”
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The Structural Basis for Activation of the Rab Ypt1p by the TRAPP Membrane-Tethering Complexes by Cai, Yiying, Chin, Harvey F., Lazarova, Darina, Menon, Shekar, Fu, Chunmei, Cai, Huaqing, Sclafani, Anthony, Rodgers, David W., De La Cruz, Enrique M., Ferro-Novick, Susan, Reinisch, Karin M.

“…The multimeric membrane-tethering complexes TRAPPI and TRAPPII share seven subunits, of which four (Bet3p, Bet5p, Trs23p, and Trs31p) are minimally needed to…”
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An Extended Polyanion Activation Surface in Insulin Degrading Enzyme by Song, Eun Suk, Ozbil, Mehmet, Zhang, Tingting, Sheetz, Michael, Lee, David, Tran, Danny, Li, Sheng, Prabhakar, Rajeev, Hersh, Louis B, Rodgers, David W

“…Insulin degrading enzyme (IDE) is believed to be the major enzyme that metabolizes insulin and has been implicated in the degradation of a number of other…”
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Active site mutations change the cleavage specificity of neprilysin by Sexton, Travis, Hitchcook, Lisa J, Rodgers, David W, Bradley, Luke H, Hersh, Louis B

“…Neprilysin (NEP), a member of the M13 subgroup of the zinc-dependent endopeptidase family is a membrane bound peptidase capable of cleaving a variety of…”
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Identification of the allosteric regulatory site of insulysin by Noinaj, Nicholas, Bhasin, Sonia K, Song, Eun Suk, Scoggin, Kirsten E, Juliano, Maria A, Juliano, Luiz, Hersh, Louis B, Rodgers, David W

“…Insulin degrading enzyme (IDE) is responsible for the metabolism of insulin and plays a role in clearance of the Aβ peptide associated with Alzheimer's…”
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A monomeric variant of insulin degrading enzyme (IDE) loses its regulatory properties by Song, Eun Suk, Rodgers, David W, Hersh, Louis B

“…Insulin degrading enzyme (IDE) is a key enzyme in the metabolism of both insulin and amyloid beta peptides. IDE is unique in that it is subject to allosteric…”
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Crystal Structure of Human Thimet Oligopeptidase Provides Insight into Substrate Recognition, Regulation, and Localization by Ray, Kallol, Hines, Christina S, Coll-Rodriguez, Jerry, Rodgers, David W

“…Thimet oligopeptidase (TOP) is a zinc metallopeptidase that metabolizes a number of bioactive peptides and degrades peptides released by the proteasome,…”
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Cysteine 904 is required for maximal insulin degrading enzyme activity and polyanion activation by Song, Eun Suk, Melikishvili, Manana, Fried, Michael G, Juliano, Maria A, Juliano, Luiz, Rodgers, David W, Hersh, Louis B

“…Cysteine residues in insulin degrading enzyme have been reported as non-critical for its activity. We found that converting the twelve cysteine residues in rat…”
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Swapping the Substrate Specificities of the Neuropeptidases Neurolysin and Thimet Oligopeptidase by Lim, Eun Jeong, Sampath, Sowmya, Coll-Rodriguez, Jerry, Schmidt, Jack, Ray, Kallol, Rodgers, David W.

“…Thimet oligopeptidase (EC 3.4.24.15) and neurolysin (EC 3.4.24.16) are closely related zinc-dependent metallopeptidases that metabolize small bioactive…”
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Impaired activity and membrane association of most calpain-5 mutants causal for neovascular inflammatory vitreoretinopathy by Geddes, James W, Bondada, Vimala, Croall, Dorothy E, Rodgers, David W, Gal, Jozsef

“…Neovascular inflammatory vitreoretinopathy (NIV) is a rare eye disease that ultimately leads to complete blindness and is caused by mutations in the gene…”
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Mass transfer along the Yellowstone hotspot track I: Petrologic constraints on the volume of mantle-derived magma by McCurry, Michael, Rodgers, David W.

“…This paper estimates mantle mass transfer to the crust along the Yellowstone–Snake River Plain (YSRP) hotspot track by applying a simple mass-balance analysis…”
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Insulin-degrading enzyme is not secreted from cultured cells by Song, Eun Suk, Rodgers, David W., Hersh, Louis B.

“…Insulin-degrading enzyme (IDE) functions in the catabolism of bioactive peptides. Established roles include degrading insulin and the amyloid beta peptide…”
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Kinematic analysis of fractures in the Great Rift, Idaho: Implications for subsurface dike geometry, crustal extension, and magma dynamics by Holmes, Adrian A. J., Rodgers, David W., Hughes, Scott S.

“…Extension across the southern Great Rift of the Eastern Snake River Plain (ESRP), Idaho, was measured to calculate the dimensions of underlying dikes and…”
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Automated parasite faecal egg counting using fluorescence labelling, smartphone image capture and computational image analysis by Slusarewicz, Paul, Pagano, Stefanie, Mills, Christopher, Popa, Gabriel, Chow, K. Martin, Mendenhall, Michael, Rodgers, David W., Nielsen, Martin K.

“…[Display omitted] •Chitin is a potential universal egg marker.•A smartphone-based system for parasite faecal egg counts was constructed.•Smartphone generated…”
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Single-domain antibodies for functional targeting of the signaling scaffold Shoc2 by Jang, HyeIn, Wilson, Patricia G., Sau, Mary, Chawla, Udeep, Rodgers, David W., Galperin, Emilia

“…•Single-domain Shoc2 antibodies (sdAbs) were selected from the synthetic phage display library of humanized llama sdAbs.•sdAbs were purified and examined for…”
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Mechanism-Informed Refinement Reveals Altered Substrate-Binding Mode for Catalytically Competent Nitroreductase by Pitsawong, Warintra, Haynes, Chad A., Koder, Ronald L., Rodgers, David W., Miller, Anne-Frances

“…Nitroreductase (NR) from Enterobacter cloacae reduces diverse nitroaromatics including herbicides, explosives, and prodrugs, and holds promise for…”
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Reduction of amyloid-beta levels in mouse eye tissues by intra-vitreally delivered neprilysin by Parthasarathy, Rajni, Chow, K. Martin, Derafshi, Zahra, Fautsch, Michael P., Hetling, John R., Rodgers, David W., Hersh, Louis B., Pepperberg, David R.

“…Amyloid-beta (Aβ) is a group of aggregation-prone, 38- to 43-amino acid peptides generated in the eye and other organs. Numerous studies suggest that the…”
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Insights into the substrate specificity of plant peptide deformylase, an essential enzyme with potential for the development of novel biotechnology applications in agriculture by Dirk, Lynnette M A, Schmidt, Jack J, Cai, Yiying, Barnes, Jonathan C, Hanger, Katherine M, Nayak, Nihar R, Williams, Mark A, Grossman, Robert B, Houtz, Robert L, Rodgers, David W

“…The crystal structure of AtPDF1B [Arabidopsis thaliana PDF (peptide deformylase) 1B; EC 3.5.1.88], a plant specific deformylase, has been determined at a…”
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Inositol phosphates and phosphoinositides activate insulin-degrading enzyme, while phosphoinositides also mediate binding to endosomes by Song, Eun Suk, Jang, HyeIn, Guo, Hou-Fu, Juliano, Maria A., Juliano, Luiz, Morris, Andrew J., Galperin, Emilia, Rodgers, David W., Hersh, Louis B.

“…Insulin-degrading enzyme (IDE) hydrolyzes bioactive peptides, including insulin, amylin, and the amyloid β peptides. Polyanions activate IDE toward some…”
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