Search Results - "Roder, John"

Behavioral Phenotypes of Disc1 Missense Mutations in Mice by Clapcote, Steven J., Lipina, Tatiana V., Millar, J. Kirsty, Mackie, Shaun, Christie, Sheila, Ogawa, Fumiaki, Lerch, Jason P., Trimble, Keith, Uchiyama, Masashi, Sakuraba, Yoshiyuki, Kaneda, Hideki, Shiroishi, Toshihiko, Houslay, Miles D., Henkelman, R. Mark, Sled, John G., Gondo, Yoichi, Porteous, David J., Roder, John C.

“…To support the role of DISC1 in human psychiatric disorders, we identified and analyzed two independently derived ENU-induced mutations in Exon 2 of mouse…”
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The involvement of the NMDA receptor d-serine/glycine site in the pathophysiology and treatment of schizophrenia by Labrie, Viviane, Roder, John C.

“…Hypofunction of the N-methyl- d-aspartate receptor (NMDAR) has been implicated in the pathophysiology of schizophrenia. The NMDAR contains a d-serine/glycine…”
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A Dopamine D2 Receptor-DISC1 Protein Complex may Contribute to Antipsychotic-Like Effects by Su, Ping, Li, Shupeng, Chen, Sheng, Lipina, Tatiana V., Wang, Min, Lai, Terence K.Y., Lee, Frankie H.F., Zhang, Hailong, Zhai, Dongxu, Ferguson, Stephen S.G., Nobrega, José N., Wong, Albert H.C., Roder, John C., Fletcher, Paul J., Liu, Fang

“…Current antipsychotic drugs primarily target dopamine D2 receptors (D2Rs), in conjunction with other receptors such as those for serotonin. However, these…”
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Mice with reduced NMDA receptor glycine affinity model some of the negative and cognitive symptoms of schizophrenia by Labrie, Viviane, Lipina, Tatiana, Roder, John C.

“…Rationale Schizophrenic patients demonstrate prominent negative and cognitive symptoms that are poorly responsive to antipsychotic treatment. Abnormal…”
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Disrupted-In-Schizophrenia-1 (DISC1) interactome and mental disorders: Impact of mouse models by LIPINA, Tatiana V, RODER, John C

“…Disrupted-In-Schizophrenia-1 (DISC1) has captured much attention because it predisposes individuals to a wide range of mental illnesses. Notably, a number of…”
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D-Serine Augments NMDA-NR2B Receptor-Dependent Hippocampal Long-Term Depression and Spatial Reversal Learning by DUFFY, Steven, LABRIE, Viviane, RODER, John C

“…The contributions of hippocampal long-term depression (LTD) to explicit learning and memory are poorly understood. Electrophysiological and behavioral studies…”
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Maternal immune activation during gestation interacts with Disc1 point mutation to exacerbate schizophrenia-related behaviors in mice by Lipina, Tatiana V, Zai, Clement, Hlousek, Daniela, Roder, John C, Wong, Albert H C

“…Schizophrenia is thought to result from interactions between susceptible genotypes and environmental risk factors. DISC1 is an important gene for schizophrenia…”
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Synergistic interactions between PDE4B and GSK-3: DISC1 mutant mice by Lipina, Tatiana V., Wang, Min, Liu, Fang, Roder, John C.

“…Disrupted-In-Schizophrenia-1 (DISC1) is a strong genetic risk factor associated with psychiatric disorders. Two distinct mutations in the second exon of the…”
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Contributions of the d-serine pathway to schizophrenia by Labrie, Viviane, Wong, Albert H.C., Roder, John C.

“…The glutamate neurotransmitter system is one of the major candidate pathways for the pathophysiology of schizophrenia, and increased understanding of the…”
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Neto1 is a novel CUB-domain NMDA receptor-interacting protein required for synaptic plasticity and learning by Ng, David, Pitcher, Graham M, Szilard, Rachel K, Sertié, Andréa, Kanisek, Marijana, Clapcote, Steven J, Lipina, Tatiana, Kalia, Lorraine V, Joo, Daisy, McKerlie, Colin, Cortez, Miguel, Roder, John C, Salter, Michael W, McInnes, Roderick R

“…The N-methyl-D-aspartate receptor (NMDAR), a major excitatory ligand-gated ion channel in the central nervous system (CNS), is a principal mediator of synaptic…”
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NCS-1 in the Dentate Gyrus Promotes Exploration, Synaptic Plasticity, and Rapid Acquisition of Spatial Memory by Saab, Bechara J., Georgiou, John, Nath, Arup, Lee, Frank J.S., Wang, Min, Michalon, Aubin, Liu, Fang, Mansuy, Isabelle M., Roder, John C.

“…The molecular underpinnings of exploration and its link to learning and memory remain poorly understood. Here we show that inducible, modest overexpression of…”
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Mania-like behavior induced by genetic dysfunction of the neuron-specific Na+,K+-ATPase α3 sodium pump by Kirshenbaum, Greer S, Clapcote, Steven J, Duffy, Steven, Burgess, Christian R, Petersen, Janne, Jarowek, Karolina J, Yücel, Yeni H, Cortez, Miguel A, Snead, O. Carter III, Vilsen, Bente, Peever, John H, Ralph, Martin R, Roder, John C

“…Bipolar disorder is a debilitating psychopathology with unknown etiology. Accumulating evidence suggests the possible involvement of Na+,K+-ATPase dysfunction…”
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A mouse model of Down syndrome trisomic for all human chromosome 21 syntenic regions by Yu, Tao, Li, Zhongyou, Jia, Zhengping, Clapcote, Steven J., Liu, Chunhong, Li, Shaomin, Asrar, Suhail, Pao, Annie, Chen, Rongqing, Fan, Ni, Carattini-Rivera, Sandra, Bechard, Allison R., Spring, Shoshana, Henkelman, R. Mark, Stoica, George, Matsui, Sei-Ichi, Nowak, Norma J., Roder, John C., Chen, Chu, Bradley, Allan, Yu, Y. Eugene

“…Down syndrome (DS) is caused by the presence of an extra copy of human chromosome 21 (Hsa21) and is the most common genetic cause for developmental cognitive…”
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Dual inhibitor of PDE7 and GSK-3 – VP1.15 acts as antipsychotic and cognitive enhancer in C57BL/6J mice by Lipina, Tatiana V., Palomo, Valle, Gil, Carmen, Martinez, Ana, Roder, John C.

“…Cognitive deficit is a core of schizophrenia and it is not effectively treated by the available antipsychotic drugs, hence new and more effective therapy is…”
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Specific Inhibition of Phosphodiesterase-4B Results in Anxiolysis and Facilitates Memory Acquisition by McGirr, Alexander, Lipina, Tatiana V, Mun, Ho-Suk, Georgiou, John, Al-Amri, Ahmed H, Ng, Enoch, Zhai, Dongxu, Elliott, Christina, Cameron, Ryan T, Mullins, Jonathan G L, Liu, Fang, Baillie, George S, Clapcote, Steven J, Roder, John C

“…Cognitive dysfunction is a core feature of dementia and a prominent feature in psychiatric disease. As non-redundant regulators of intracellular cAMP…”
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Cognitive Deficits in Calsyntenin-2-deficient Mice Associated with Reduced GABAergic Transmission by Lipina, Tatiana V, Prasad, Tuhina, Yokomaku, Daisaku, Luo, Lin, Connor, Steven A, Kawabe, Hiroshi, Wang, Yu Tian, Brose, Nils, Roder, John C, Craig, Ann Marie

“…Calsyntenin-2 has an evolutionarily conserved role in cognition. In a human genome-wide screen, the CLSTN2 locus was associated with verbal episodic memory,…”
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Mice lacking neuronal calcium sensor-1 show social and cognitive deficits by Ng, Enoch, Georgiou, John, Avila, Ariel, Trought, Kathleen, Mun, Ho-Suk, Hodgson, Meggie, Servinis, Panayiotis, Roder, John C., Collingridge, Graham L., Wong, Albert H.C.

“…•Neuronal Calcium Sensor-1 (NCS-1) is implicated in brain disorders.•Ncs1 knockout mice have a mild deficit in social approach.•Ncs1 knockout mice have…”
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Mania-like behavior induced by genetic dysfunction of the neuron-specific Na+,K+-ATPase alpha 3 sodium pump by Kirshenbaum, Greer S, Clapcote, Steven J, Duffy, Steven, Burgess, Christian R, Petersen, Janne, Jarowek, Karolina J, Yuecel, Yeni H, Cortez, Miguel A, Snead, OCarter, Vilsen, Bente, Peever, John H, Ralph, Martin R, Roder, John C

“…Bipolar disorder is a debilitating psychopathology with unknown etiology. Accumulating evidence suggests the possible involvement of Na+,K+-ATPase dysfunction…”
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A Far-Red Emitting Probe for Unambiguous Detection of Mobile Zinc in Acidic Vesicles and Deep Tissue by Rivera-Fuentes, Pablo, Wrobel, Alexandra T, Zastrow, Melissa L, Khan, Mustafa, Georgiou, John, Luyben, Thomas T, Roder, John C, Okamoto, Kenichi, Lippard, Stephen J

“…Imaging mobile zinc in acidic environments remains challenging because most small-molecule optical probes display pH-dependent fluorescence. Here we report a…”
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Characterization of Cognitive Deficits in Mice With an Alternating Hemiplegia-Linked Mutation by Kirshenbaum, Greer S., Dachtler, James, Roder, John C., Clapcote, Steven J.

“…Cognitive impairment is a prominent feature in a range of different movement disorders. Children with Alternating Hemiplegia of Childhood are prone to…”
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