Search Results - "Rodenburg, Lisa W."

Exploring intrinsic variability between cultured nasal and bronchial epithelia in cystic fibrosis by Rodenburg, Lisa W., Metzemaekers, Mieke, van der Windt, Isabelle S., Smits, Shannon M. A., den Hertog-Oosterhoff, Loes A., Kruisselbrink, Evelien, Brunsveld, Jesse E., Michel, Sabine, de Winter-de Groot, Karin M., van der Ent, Cornelis K., Stadhouders, Ralph, Beekman, Jeffrey M., Amatngalim, Gimano D.

“…The nasal and bronchial epithelium are unified parts of the respiratory tract that are affected in the monogenic disorder cystic fibrosis (CF). Recent studies…”
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Protocol for generating airway organoids from 2D air liquid interface-differentiated nasal epithelia for use in a functional CFTR assay by Rodenburg, Lisa W., van der Windt, Isabelle S., Dreyer, Henriette H.M., Smits, Shannon M.A., den Hertog - Oosterhoff, Loes A., Aarts, Ellen M., Beekman, Jeffrey M., Amatngalim, Gimano D.

“…We present a protocol to generate organoids from air-liquid-interface (ALI)-differentiated nasal epithelia. We detail their application as cystic fibrosis (CF)…”
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Dynamic regulation of airway surface liquid pH by TMEM16A and SLC26A4 in cystic fibrosis nasal epithelia with rare mutations by Delpiano, Livia, Rodenburg, Lisa W., Burke, Matthew, Nelson, Glyn, Amatngalim, Gimano D., Beekman, Jeffrey M., Gray, Michael A.

“…In cystic fibrosis (CF), defects in the CF transmembrane conductance regulator (CFTR) channel lead to an acidic airway surface liquid (ASL), which compromises…”
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The SLC26A9 inhibitor S9‐A13 provides no evidence for a role of SLC26A9 in airway chloride secretion but suggests a contribution to regulation of ASL pH and gastric proton secretion by Jo, Sungwoo, Centeio, Raquel, Park, Jinhong, Ousingsawat, Jiraporn, Jeon, Dong‐kyu, Talbi, Khaoula, Schreiber, Rainer, Ryu, Kunhi, Kahlenberg, Kristin, Somoza, Veronika, Delpiano, Livia, Gray, Michael A., Amaral, Margarida D., Railean, Violeta, Beekman, Jeffrey M., Rodenburg, Lisa W., Namkung, Wan, Kunzelmann, Karl

“…The solute carrier 26 family member A9 (SLC26A9) is an epithelial anion transporter that is assumed to contribute to airway chloride secretion and surface…”
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Recurrent Respiratory Syncytial Virus Infection in a CD14-Deficient Patient by Besteman, Sjanna B, Phung, Emily, Raeven, Henriette H M, Amatngalim, Gimano D, Rumpret, Matevž, Crabtree, Juliet, Schepp, Rutger M, Rodenburg, Lisa W, Siemonsma, Susanna G, Verleur, Nile, van Slooten, Rianne, Duran, Karen, van Haaften, Gijs W, Beekman, Jeffrey M, Chang, Lauren A, Meyaard, Linde, van der Bruggen, Tjomme, Berbers, Guy A M, Derksen, Nicole, Nierkens, Stefan, Morabito, Kaitlyn M, Ruckwardt, Tracy J, Kurt-Jones, Evelyn A, Golenbock, Douglas, Graham, Barney S, Bont, Louis J

“…Abstract Background Recurrent respiratory syncytial virus (RSV) infection requiring hospitalization is rare and the underlying mechanism is unknown. We aimed…”
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Drug Repurposing for Cystic Fibrosis: Identification of Drugs That Induce CFTR-Independent Fluid Secretion in Nasal Organoids by Rodenburg, Lisa W, Delpiano, Livia, Railean, Violeta, Centeio, Raquel, Pinto, Madalena C, Smits, Shannon M A, van der Windt, Isabelle S, van Hugten, Casper F J, van Beuningen, Sam F B, Rodenburg, Remco N P, van der Ent, Cornelis K, Amaral, Margarida D, Kunzelmann, Karl, Gray, Michael A, Beekman, Jeffrey M, Amatngalim, Gimano D

“…Individuals with cystic fibrosis (CF) suffer from severe respiratory disease due to a genetic defect in the cystic fibrosis transmembrane conductance regulator…”
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Measuring cystic fibrosis drug responses in organoids derived from 2D differentiated nasal epithelia by Amatngalim, Gimano D, Rodenburg, Lisa W, Aalbers, Bente L, Raeven, Henriette Hm, Aarts, Ellen M, Sarhane, Dounia, Spelier, Sacha, Lefferts, Juliet W, Silva, Iris Al, Nijenhuis, Wilco, Vrendenbarg, Sacha, Kruisselbrink, Evelien, Brunsveld, Jesse E, van Drunen, Cornelis M, Michel, Sabine, de Winter-de Groot, Karin M, Heijerman, Harry G, Kapitein, Lukas C, Amaral, Magarida D, van der Ent, Cornelis K, Beekman, Jeffrey M

“…Cystic fibrosis is caused by genetic defects that impair the CFTR channel in airway epithelial cells. These defects may be overcome by specific CFTR modulating…”
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Airway Epithelial Cultures of Children with Esophageal Atresia as a Model to Study Respiratory Tract Disorders by Dreyer, Henriette H M, van Tuyll van Serooskerken, Eleonora Sofie, Rodenburg, Lisa W, Bittermann, Arnold J N, Arets, Hubertus G M, Reuling, Ellen M B P, Verweij, Johannes W, Haarman, Eric G, van der Zee, David C, Tytgat, Stefaan H A J, van der Ent, Cornelis K, Beekman, Jeffrey M, Amatngalim, Gimano D, Lindeboom, Maud Y A

“…Esophageal atresia (EA) is a rare birth defect in which respiratory tract disorders are a major cause of morbidity. It remains unclear whether respiratory…”
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