Search Results - "Rodell, Rebecca"
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The ASCC2 CUE domain in the ALKBH3–ASCC DNA repair complex recognizes adjacent ubiquitins in K63-linked polyubiquitin
Published in The Journal of biological chemistry (01-02-2022)“…Alkylation of DNA and RNA is a potentially toxic lesion that can result in mutations and even cell death. In response to alkylation damage, K63-linked…”
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Why U matters: detection and functions of pseudouridine modifications in mRNAs
Published in Trends in biochemical sciences (Amsterdam. Regular ed.) (01-01-2024)“…The uridine modifications pseudouridine (Ψ), dihydrouridine, and 5-methyluridine are present in eukaryotic mRNAs. Many uridine-modifying enzymes are associated…”
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Use of High-Performance Liquid Chromatography-Mass Spectrometry (HPLC-MS) to Quantify Modified Nucleosides
Published in Methods in molecular biology (Clifton, N.J.) (2022)“…Physiological and chemically induced modifications to nucleosides are common in both DNA and RNA. Physiological forms of these modifications play critical…”
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Aberrant RNA methylation triggers recruitment of an alkylation repair complex
Published in Molecular cell (21-10-2021)“…Central to genotoxic responses is their ability to sense highly specific signals to activate the appropriate repair response. We previously reported that the…”
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SMYD3 Impedes Small Cell Lung Cancer Sensitivity to Alkylation Damage through RNF113A Methylation-Phosphorylation Cross-talk
Published in Cancer discovery (02-09-2022)“…Small cell lung cancer (SCLC) is the most fatal form of lung cancer, with dismal survival, limited therapeutic options, and rapid development of…”
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