Search Results - "Rockwood, K"

Frailty in Relation to the Accumulation of Deficits by Rockwood, Kenneth, Mitnitski, Arnold

“…This review article summarizes how frailty can be considered in relation to deficit accumulation. Recalling that frailty is an age-associated, nonspecific…”
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Bed rest and accelerated aging in relation to the musculoskeletal and cardiovascular systems and frailty biomarkers: A review by Kehler, D.S., Theou, O., Rockwood, K.

“…Prolonged bed rest and lifelong physical inactivity cause deleterious effects to multiple physiological systems that appear to hasten aging processes. Many…”
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A Frailty Index Based On Deficit Accumulation Quantifies Mortality Risk in Humans and in Mice by Rockwood, K., Blodgett, J. M., Theou, O., Sun, M. H., Feridooni, H. A., Mitnitski, A., Rose, R. A., Godin, J., Gregson, E., Howlett, S. E.

“…Although many common diseases occur mostly in old age, the impact of ageing itself on disease risk and expression often goes unevaluated. To consider the…”
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Size of the treatment effect on cognition of cholinesterase inhibition in Alzheimer’s disease by Rockwood, K

“…Background: Six cholinesterase inhibitors (ChEIs) have been tested in people with Alzheimer’s disease, using methods currently required for regulatory…”
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A Comparison of Two Approaches to Measuring Frailty in Elderly People by Rockwood, Kenneth, Andrew, Melissa, Mitnitski, Arnold

“…Background. Many definitions of frailty exist, but few have been directly compared. We compared the relationship between a definition of frailty based on a…”
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An Individualized Approach to Tracking and Treating Alzheimer's Disease by Rockwood, K

“…There can be substantial variation in the expression of Alzheimer's disease. Patients vary in who is affected (e.g., education, age at onset), in how they are…”
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Aging, frailty and complex networks by Mitnitski, A. B., Rutenberg, A. D., Farrell, S., Rockwood, K.

“…When people age their mortality rate increases exponentially, following Gompertz’s law. Even so, individuals do not die from old age. Instead, they accumulate…”
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Epidemiological and clinical trials evidence about a preventive role for statins in Alzheimer's disease by Rockwood, K.

“…This paper reviews epidemiological and clinical trials data about whether statin use reduces the risk of Alzheimer's disease (AD). The available information…”
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A global clinical measure of fitness and frailty in elderly people by Rockwood, Kenneth, Song, Xiaowei, MacKnight, Chris, Bergman, Howard, Hogan, David B, McDowell, Ian, Mitnitski, Arnold

“…There is no single generally accepted clinical definition of frailty. Previously developed tools to assess frailty that have been shown to be predictive of…”
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Transitions in cognitive status in relation to frailty in older adults: A Comparison of three frailty measures by Mitnitski, A., Fallah, N., Rockwood, M. R. H., Rockwood, K.

“…Objectives Cognitive decline is related to frailty. Frailty can be operationalized in different ways, which have an unknown impact on the estimation of risk…”
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Frailty, Body Mass Index, and Abdominal Obesity in Older People by Hubbard, Ruth E., Lang, Iain A., Llewellyn, David J., Rockwood, Kenneth

“…Background Frailty has been conceptualized as a wasting disorder with weight loss as a key component. However, obesity is associated with disability and with…”
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Trajectories of changes over twelve years in the health status of Canadians from late middle age by Mitnitski, A., Song, X., Rockwood, K.

“…Aging in a given individual can be characterized by the number of deficits (symptoms, signs, laboratory abnormalities, disabilities) that they accumulate. The…”
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Comparison of the prognostic importance of diagnosed diabetes, co-morbidity and frailty in older people by Hubbard, R. E., Andrew, M. K., Fallah, N., Rockwood, K.

“…Diabet. Med. 27, 603–606 (2010) Aims  To compare the relative prognostic importance in older people of diagnosed diabetes, the number and severity of…”
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Frailty and its quantitative clinical evaluation by Moorhouse, P, Rockwood, K

“…Frailty is a progressive physiological decline in multiple organ systems marked by loss of function, loss of physiological reserve and increased vulnerability…”
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Measuring frailty using self-report and test-based health measures by Theou, O, O'Connell, M D L, King-Kallimanis, B L, O'Halloran, A M, Rockwood, K, Kenny, R A

“…previously, frailty indices were constructed using mostly subjective health measures. The reporting error in this type of measure can have implications on the…”
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Subjective memory complaints and incident dementia in a high risk older adult hypertensive population by Peters, R, Beckett, N, Antikainen, R, Rockwood, K, Bulpitt, C J, Anstey, K J

“…Abstract Background there is a growing body of evidence demonstrating an association between subjective memory complaints (SMC) and an increased risk of…”
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Prevalence of and factors associated with frailty and disability in older adults from China, Ghana, India, Mexico, Russia and South Africa by Biritwum, R.B, Minicuci, N, Yawson, A.E, Theou, O, Mensah, G.P, Naidoo, N, Wu, F, Guo, Y, Zheng, Y, Jiang, Y, Maximova, T, Kalula, S, Arokiasamy, P, Salinas-Rodríguez, A, Manrique-Espinoza, B, Snodgrass, J.J, Sterner, K.N, Eick, G, Liebert, M.A, Schrock, J, Afshar, S, Thiele, E, Vollmer, S, Harttgen, K, Strulik, H, Byles, JE, Rockwood, K, Mitnitski, A, Chatterji, S, Kowal, P

“…Highlights • Estimates are provided of the prevalence of frailty and disability in older adult populations in China, Ghana, India, Mexico, Russia and South…”
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A Frailty Index predicts 10-year fracture risk in adults age 25 years and older: results from the Canadian Multicentre Osteoporosis Study (CaMos) by Kennedy, C. C., Ioannidis, G., Rockwood, K., Thabane, L., Adachi, J. D., Kirkland, S., Pickard, L. E., Papaioannou, A.

“…Summary We created a 30-item Frailty Index in the Canadian Multicentre Osteoporosis Study. A Frailty Index is a sensitive measure that can quantify fracture…”
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An MDS-specific frailty index based on cumulative deficits adds independent prognostic information to clinical prognostic scoring by Starkman, R., Alibhai, S., Wells, R. A., Geddes, M., Zhu, N., Keating, M. M., Leber, B., Chodirker, L., Sabloff, M., Christou, G., Leitch, H. A., St-Hilaire, E., Finn, N., Shamy, A., Yee, K., Storring, J., Nevill, T., Delage, R., Elemary, M., Banerji, V., Lenis, M., Kirubananthaan, A., Mamedov, A., Zhang, L., Rockwood, K., Buckstein, R.

“…The frailty index (FI) is based on the principle that the more deficits an individual has, the greater their risk of adverse outcomes. It is expressed as a…”
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Correlates of frailty phenotype and frailty index and their associations with clinical outcomes by Guaraldi, G, Malagoli, A, Theou, O, Brothers, TD, Wallace, LMK, Torelli, R, Mussini, C, Sartini, S, Kirkland, SA, Rockwood, K

“…Objectives Frailty is a predictor of adverse health outcomes and can be measured across the life course, including among people living with HIV. The purpose of…”
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