Search Results - "Rockman, H."

Functional consequences of altering myocardial adrenergic receptor signaling by Koch, W J, Lefkowitz, R J, Rockman, H A

“…From the ability to successfully manipulate the mouse genome has come important transgenic and gene-targeted knockout models that impact many areas of…”
Get full text

Cardiac Function in Mice Overexpressing the β-Adrenergic Receptor Kinase or a βARK Inhibitor by Koch, Walter J., Rockman, Howard A., Samama, Philippe, Hamilton, RaeAnn, Bond, Richard A., Milano, Carmelo A., Lefkowitz, Robert J.

“…Transgenic mice were created with cardiac-specific overexpression of the β-adrenergic receptor kinase-1 (βARK1) or a βARK inhibitor. Animals overexpressing…”
Get full text

Hypertension and albuminuria in chronic kidney disease mapped to a mouse chromosome 11 locus by Salzler, H.R., Griffiths, R., Ruiz, P., Chi, L., Frey, C., Marchuk, D.A., Rockman, H.A., Le, T.H.

“…Chronic kidney disease (CKD) is a key cause of hypertension and a potent independent risk for cardiovascular disease. Epidemiological studies suggest a strong…”
Get full text

Enhanced myocardial function in transgenic mice overexpressing the β2-adrenergic receptor by MILANO, C. A, ALLEN, L. F, ROCKMAN, H. A, DOLBER, P. C, MCMINN, T. R, CHIEN, K. R, JOHNSON, T. D, BOND, R. A, LEFKOWITZ, R. J

Get full text

Transthoracic echocardiography in models of cardiac disease in the mouse by TANAKA, N, DALTON, N, MAO, L, ROCKMAN, H. A, PETERSON, K. L, GOTTSHALL, K. R, HUNTER, J. J, CHIEN, K. R, ROSS, J. JR

“…Transthoracic echocardiography (M-mode and Doppler) offers a noninvasive approach for in vivo evaluation of the mouse heart. The present study examines its…”
Get full text

Overexpression of the rat sarcoplasmic reticulum Ca2+ ATPase gene in the heart of transgenic mice accelerates calcium transients and cardiac relaxation by He, H, Giordano, F J, Hilal-Dandan, R, Choi, D J, Rockman, H A, McDonough, P M, Bluhm, W F, Meyer, M, Sayen, M R, Swanson, E, Dillmann, W H

“…The Ca2+ ATPase of the sarcoplasmic reticulum (SERCA2) plays a dominant role in lowering cytoplasmic calcium levels during cardiac relaxation and reduction of…”
Get full text

Genetic alterations that inhibit in vivo pressure-overload hypertrophy prevent cardiac dysfunction despite increased wall stress by Esposito, Giovanni, Rapacciuolo, Antonio, Naga Prasad, Sathyamangla V, Takaoka, Hideyuki, Thomas, Steven A, Koch, Walter J, Rockman, Howard A

“…A long-standing hypothesis has been that hypertrophy is compensatory and by normalizing wall stress acts to maintain normal cardiac function. Epidemiological…”
Get full text

ANG II receptor blockade prevents ventricular hypertrophy and ANF gene expression with pressure overload in mice by Rockman, H A, Wachhorst, S P, Mao, L, Ross, Jr, J

“…There is increasing evidence that the renin-angiotensin system may play a important role in cardiac hypertrophy. To assess the role of angiotensin II in the…”
Get full text

Regional absence of mitochondria causing energy depletion in the myocardium of muscle LIM protein knockout mice by VAN DEN BOSCH, Bianca J. C, VAN DEN BURG, Caroline M. M, SCHOONDERWOERD, Kees, LINDSEY, Patrick J, SCHOLTE, Hans R, DE COO, René F. M, VAN ROOIJ, Eva, ROCKMAN, Howard A, DOEVENDANS, Pieter A, SMEETS, Hubert J. M

“…Defects in myocardial mitochondrial structure and function have been associated with heart failure in humans and animal models. Mice lacking the muscle LIM…”
Get full text

Catecholamines, cardiac beta-adrenergic receptors, and heart failure by Lefkowitz, R J, Rockman, H A, Koch, W J

Get full text

Segregation of Atrial-Specific and Inducible Expression of an Atrial Natriuretic Factor Transgene in an in vivo Murine Model of Cardiac Hypertrophy by Rockman, Howard A., Ross, Robert S., Harris, Adrienne N., Knowlton, Kirk U., Steinhelper, Mark E., Field, Loren J., Ross, John, Chien, Kenneth R.

“…To study the mechanisms that activate expression of the atrial natriuretic factor (ANF) gene during pressure-induced hypertrophy, we have developed and…”
Get full text

Pressure-independent enhancement of cardiac hypertrophy in natriuretic peptide receptor A-deficient mice by Knowles, J W, Esposito, G, Mao, L, Hagaman, J R, Fox, J E, Smithies, O, Rockman, H A, Maeda, N

“…Mice lacking natriuretic peptide receptor A (NPRA) have marked cardiac hypertrophy and chamber dilatation disproportionate to their increased blood pressure…”
Get full text

Cardiac βARK1 Inhibition Prolongs Survival and Augments β Blocker Therapy in a Mouse Model of Severe Heart Failure by Harding, Victoria B., Jones, Larry R., Lefkowitz, Robert J., Koch, Walter J., Rockman, Howard A.

“…Chronic human heart failure is characterized by abnormalities in β-adrenergic receptor (βAR) signaling, including increased levels of βAR kinase 1 (βARK1),…”
Get full text

In vivo inhibition of elevated myocardial β-adrenergic receptor kinase activity in hybrid transgenic mice restores normal β-adrenergic signaling and function by AKHTER, S. A, ECKHART, A. D, ROCKMAN, H. A, SHOTWELL, K, LEFKOWITZ, R. J, KOCH, W. J

“…The clinical syndrome of heart failure (HF) is characterized by an impaired cardiac beta-adrenergic receptor (betaAR) system, which is critical in the…”
Get full text

Receptor-Specific in vivo Desensitization by the G Protein-Coupled Receptor Kinase-5 in Transgenic Mice by Rockman, Howard A., Choi, Dong-Ju, Rahman, Nadeem U., Akhter, Shahab A., Lefkowitz, Robert J., Koch, Walter J.

“…Transgenic mice were generated with cardiac-specific overexpression of the G protein-coupled receptor kinase-5 (GRK5), a serine/threonine kinase most…”
Get full text

Expression of a β -adrenergic Receptor Kinase 1 Inhibitor Prevents the Development of Myocardial Failure in Gene-Targeted Mice by Rockman, Howard A., Chien, Kenneth R., Choi, Dong-Ju, Iaccarino, Guido, Hunter, John J., Ross, John, Lefkowitz, Robert J., Koch, Walter J.

“…Heart failure is accompanied by severely impaired β -adrenergic receptor (β AR) function, which includes loss of β AR density and functional uncoupling of…”
Get full text

Agonist-dependent recruitment of phosphoinositide 3-kinase to the membrane by beta-adrenergic receptor kinase 1. A role in receptor sequestration by Naga Prasad, S V, Barak, L S, Rapacciuolo, A, Caron, M G, Rockman, H A

“…Agonist-dependent desensitization of the beta-adrenergic receptor requires translocation and activation of the beta-adrenergic receptor kinase1 by liberated…”
Get full text

Molecular and Physiological Alterations in Murine Ventricular Dysfunction by Rockman, Howard A., Ono, Satoko, Ross, Robert S., Jones, Larry R., Karimi, Mohsin, Bhargava, Valmik, Ross, John, Chien, Kenneth R.

“…The present study reports the development and characterization of a murine model of right ventricular dysfunction following graded constriction in the…”
Get full text

Hypertension, Cardiac Hypertrophy, and Sudden Death in Mice Lacking Natriuretic Peptide Receptor A by Oliver, P M, Fox, J E, Kim, R, Rockman, H A, Kim, H S, Reddick, R L, Pandey, K N, Milgram, S L, Smithies, O, Maeda, N

“…Natriuretic peptides, produced in the heart, bind to the natriuretic peptide receptor A (NPRA) and cause vasodilation and natriuresis important in the…”
Get full text

Cardiac function in genetically engineered mice with altered adrenergic receptor signaling by Rockman, H A, Koch, W J, Lefkowitz, R J

“…In disease states such as heart failure, catecholamines released from sympathetic nerve endings and the adrenal medulla play a central role in the adaptive and…”
Get full text