Search Results - "Rock, Kylie D"

Extracellular vesicles are dynamic regulators of maternal glucose homeostasis during pregnancy by Zierden, Hannah C., Marx-Rattner, Ruth, Rock, Kylie D., Montgomery, Kristen R., Anastasiadis, Pavlos, Folts, Lillian, Bale, Tracy L.

“…Homeostatic regulation of the maternal milieu during pregnancy is critical for maternal and fetal health. The placenta facilitates critical communication…”
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The composition of human vaginal microbiota transferred at birth affects offspring health in a mouse model by Jašarević, Eldin, Hill, Elizabeth M., Kane, Patrick J., Rutt, Lindsay, Gyles, Trevonn, Folts, Lillian, Rock, Kylie D., Howard, Christopher D., Morrison, Kathleen E., Ravel, Jacques, Bale, Tracy L.

“…Newborns are colonized by maternal microbiota that is essential for offspring health and development. The composition of these pioneer communities exhibits…”
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A Critical Review and Meta-Analysis of Impacts of Per- and Polyfluorinated Substances on the Brain and Behavior by Starnes, Hannah M, Rock, Kylie D, Jackson, Thomas W, Belcher, Scott M

“…Per- and polyfluoroalkyl substances (PFAS) are a class of structurally diverse synthetic organic chemicals that are chemically stable, resistant to…”
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Developmental transcriptomic patterns can be altered by transgenic overexpression of Uty by Rock, Kylie D., Folts, Lillian M., Zierden, Hannah C., Marx-Rattner, Ruth, Leu, Nicolae Adrian, Nugent, Bridget M., Bale, Tracy L.

“…The genetic material encoded on X and Y chromosomes provides the foundation by which biological sex differences are established. Epigenetic regulators…”
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Sex-specific behavioral effects following developmental exposure to tetrabromobisphenol A (TBBPA) in Wistar rats by Rock, Kylie D., Gillera, Sagi Enicole A., Devarasetty, Pratyush, Horman, Brian, Knudsen, Gabriel, Birnbaum, Linda S., Fenton, Suzanne E., Patisaul, Heather B.

“…•Tetrabromobisphenol A (TBBPA) is a flame retardant and suspected endocrine disruptor.•Here we examined the impact of developmental TBBPA exposure on sexually…”
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Developmental Exposure to the Flame Retardant Mixture Firemaster 550 Compromises Adult Bone Integrity in Male but not Female Rats by Macari, Soraia, Rock, Kylie D, Santos, Mariana S, Lima, Virgínia T M, Szawka, Raphael E, Moss, Jamal, Horman, Brian, Patisaul, Heather B

“…Flame retardants (FRs) are used in a variety of common items from furniture to carpet to electronics to reduce flammability and combustion, but the potential…”
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EDC IMPACT: Molecular effects of developmental FM 550 exposure in Wistar rat placenta and fetal forebrain by Rock, Kylie D, Horman, Brian, Phillips, Allison L, McRitchie, Susan L, Watson, Scott, Deese-Spruill, Jocelin, Jima, Dereje, Sumner, Susan, Stapleton, Heather M, Patisaul, Heather B

“…Firemaster 550 (FM 550) is a flame retardant (FR) mixture that has become one of the most commonly used FRs in foam-based furniture and baby products. Human…”
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Microphysiological systems of the placental barrier by Arumugasaamy, Navein, Rock, Kylie D., Kuo, Che-Ying, Bale, Tracy L., Fisher, John P.

“…Methods to evaluate maternal-fetal transport across the placental barrier have generally involved clinical observations after-the-fact, ex vivo perfused…”
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Quantitative cross-species comparison of serum albumin binding of per- and polyfluoroalkyl substances from five structural classes by Starnes, Hannah M, Jackson, Thomas W, Rock, Kylie D, Belcher, Scott M

“…Abstract Per- and polyfluoroalkyl substances (PFAS) are a class of over 8000 chemicals, many of which are persistent, bioaccumulative, and toxic to humans,…”
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Environmental Mechanisms of Neurodevelopmental Toxicity by Rock, Kylie D., Patisaul, Heather B.

“…Purpose of Review With the incidence of neurodevelopmental disorders on the rise, it is imperative to identify and understand the mechanisms by which…”
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Domestic Dogs and Horses as Sentinels of Per- and Polyfluoroalkyl Substance Exposure and Associated Health Biomarkers in Gray’s Creek North Carolina by Rock, Kylie D., Polera, Madison E., Guillette, Theresa C., Starnes, Hannah M., Dean, Kentley, Watters, Mike, Stevens-Stewart, Debra, Belcher, Scott M.

“…Central North Carolina (NC) is highly contaminated with per- and polyfluoroalkyl substances (PFAS), in part due to local fluorochemical production. Little is…”
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Combined screening and retroactive data mining for emerging perfluoroethers in wildlife and pets in the Cape Fear region of North Carolina by Bangma, Jacqueline, Pu, Shirley, Robuck, Anna, Boettger, Jason, Guillette, Theresa, McCord, James, Rock, Kylie D., Sobus, Jon, Jackson, Thomas W., Belcher, Scott M.

“…The recent application of non-targeted analysis (NTA) techniques in environmental monitoring has revealed numerous novel fluorinated species in surface water,…”
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PBDEs Concentrate in the Fetal Portion of the Placenta: Implications for Thyroid Hormone Dysregulation by Ruis, Matthew T, Rock, Kylie D, Hall, Samantha M, Horman, Brian, Patisaul, Heather B, Stapleton, Heather M

“…During pregnancy, the supply of thyroid hormone (TH) to the fetus is critically important for fetal growth, neural development, metabolism, and maintenance of…”
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Comparative assessment of blood mercury in American alligators (Alligator mississippiensis) from Coastal North Carolina and Florida by Belcher, Scott M., Guillette, Matthew P., Robb, Frank, Rock, Kylie D.

“…Mercury (Hg) is a widespread and harmful persistent pollutant of aquatic ecosystems. Except for the northern most populations of American alligators (…”
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Effects of Prenatal Exposure to a Mixture of Organophosphate Flame Retardants on Placental Gene Expression and Serotonergic Innervation in the Fetal Rat Brain by Rock, Kylie D, St Armour, Genevieve, Horman, Brian, Phillips, Allison, Ruis, Matthew, Stewart, Allison K, Jima, Dereje, Muddiman, David C, Stapleton, Heather M, Patisaul, Heather B

“…Abstract There is a growing need to understand the potential neurotoxicity of organophosphate flame retardants (OPFRs) and plasticizers because use and,…”
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Maternal organophosphate flame retardant exposure alters the developing mesencephalic dopamine system in fetal rat by Newell, Andrew J, Kapps, Victoria A, Cai, Yuheng, Rai, Mani Ratnam, St Armour, Genevieve, Horman, Brian M, Rock, Kylie D, Witchey, Shannah K, Greenbaum, Alon, Patisaul, Heather B

“…Organophosphate flame retardants (OPFRs) have become the predominant substitution for legacy brominated flame retardants but there is concern about their…”
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Developmental toxicity of the PBDE metabolite 6-OH-BDE-47 in zebrafish and the potential role of thyroid receptor β by Macaulay, Laura J., Chen, Albert, Rock, Kylie D., Dishaw, Laura V., Dong, Wu, Hinton, David E., Stapleton, Heather M.

“…•6-OH-BDE-47 was the most acutely toxic halogenated phenol tested of 11 chemicals.•Embryonic exposure to 6-OH-BDE-47 resulted in developmental delays in…”
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Heterozygous mutation of sonic hedgehog receptor (Ptch1) drives cerebellar overgrowth and sex-specifically alters hippocampal and cortical layer structure, activity, and social behavior in female mice by Jackson, Thomas W., Bendfeldt, Gabriel A., Beam, Kelby A., Rock, Kylie D., Belcher, Scott M.

“…Sonic hedgehog (SHH) signaling is essential for the differentiation and migration of early stem cell populations during cerebellar development. Dysregulation…”
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Editor's Highlight: Transplacental and Lactational Transfer of Firemaster® 550 Components in Dosed Wistar Rats by Phillips, Allison L, Chen, Albert, Rock, Kylie D, Horman, Brian, Patisaul, Heather B, Stapleton, Heather M

“…Firemaster® 550 (FM 550) is a commercial mixture of organophosphate and brominated flame retardants currently in use as a replacement for pentaBDE. Its…”
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