Search Results - "Rock, Kenneth L."

Cancer Immune Evasion Through Loss of MHC Class I Antigen Presentation by Dhatchinamoorthy, Karthik, Colbert, Jeff D, Rock, Kenneth L

“…Major histocompatibility class I (MHC I) molecules bind peptides derived from a cell's expressed genes and then transport and display this antigenic…”
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Cross-presentation of exogenous antigens on MHC I molecules by Colbert, Jeff D, Cruz, Freidrich M, Rock, Kenneth L

“…•Dendritic cells internalize exogenous antigens for cross-presentation on MHC I.•MHC I cross-presentation allows immune surveillance of viral infection and…”
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The Biology and Underlying Mechanisms of Cross-Presentation of Exogenous Antigens on MHC-I Molecules by Cruz, Freidrich M, Colbert, Jeff D, Merino, Elena, Kriegsman, Barry A, Rock, Kenneth L

“…To monitor the health of cells, the immune system tasks antigen-presenting cells with gathering antigens from other cells and bringing them to CD8 T cells in…”
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The sterile inflammatory response by Rock, Kenneth L, Latz, Eicke, Ontiveros, Fernando, Kono, Hajime

“…The acute inflammatory response is a double-edged sword. On the one hand, it plays a key role in initial host defense, particularly against many infections. On…”
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The inflammatory response to cell death by Rock, Kenneth L, Kono, Hajime

“…When cells die in vivo, they trigger an inflammatory response. The ensuing hyperemia, leak of plasma proteins, and recruitment of leukocytes serve a number of…”
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Uric acid as a danger signal in gout and its comorbidities by Rock, Kenneth L., Kataoka, Hiroshi, Lai, Jiann-Jyh

“…Uric acid not only triggers inflammation in gout in its crystallized form, monosodium urate, but is also associated with comorbidities of the disease. New…”
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Uric acid promotes an acute inflammatory response to sterile cell death in mice by Kono, Hajime, Chen, Chun-Jen, Ontiveros, Fernando, Rock, Kenneth L

“…Necrosis stimulates inflammation, and this response is medically relevant because it contributes to the pathogenesis of a number of diseases. It is thought…”
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Innate and adaptive immune responses to cell death by Rock, Kenneth L., Lai, Jiann-Jyh, Kono, Hajime

“…The immune system plays an essential role in protecting the host against infections and to accomplish this task has evolved mechanisms to recognize microbes…”
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Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization by Halle, Annett, Rock, Kenneth L, Latz, Eicke, Fitzgerald, Katherine A, Bauernfeind, Franz, Hornung, Veit, Samstad, Eivind O, Kono, Hajime

“…Activation of the NALP3 inflammasome induces interleukin 1β production and inflammation. Latz and colleagues show that silica uptake followed by lysosome…”
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Frequent Loss of IRF2 in Cancers Leads to Immune Evasion through Decreased MHC Class I Antigen Presentation and Increased PD-L1 Expression by Kriegsman, Barry A, Vangala, Pranitha, Chen, Benjamin J, Meraner, Paul, Brass, Abraham L, Garber, Manuel, Rock, Kenneth L

“…To arise and progress, cancers need to evade immune elimination. Consequently, progressing tumors are often MHC class I (MHC-I) low and express immune…”
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Identification of a key pathway required for the sterile inflammatory response triggered by dying cells by Rock, Kenneth L, Chen, Chun-Jen, Kono, Hajime, Golenbock, Douglas, Reed, George, Akira, Shizuo

“…Dying cells stimulate inflammation, and this response is thought to contribute to the pathogenesis of many diseases. Very little has been known, however, about…”
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Cross-presentation: underlying mechanisms and role in immune surveillance by Rock, Kenneth L., Shen, Lianjun

“…It was originally thought that a cell's major histocompatibility complex (MHC) class I molecules presented peptides derived exclusively from proteins…”
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Evaluation of the contribution of multiple DAMPs and DAMP receptors in cell death-induced sterile inflammatory responses by Kataoka, Hiroshi, Kono, Hajime, Patel, Zubin, Kimura, Yoshitaka, Rock, Kenneth L

“…When cells die by necrosis in vivo they stimulate an inflammatory response. It is thought that this response is triggered when the injured cells expose…”
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The xanthine oxidase inhibitor Febuxostat reduces tissue uric acid content and inhibits injury-induced inflammation in the liver and lung by Kataoka, Hiroshi, Yang, Ke, Rock, Kenneth L.

“…Necrotic cell death in vivo induces a robust neutrophilic inflammatory response and the resulting inflammation can cause further tissue damage and disease…”
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Mice completely lacking immunoproteasomes show major changes in antigen presentation by Kincaid, Eleanor Z, Che, Jenny W, York, Ian, Escobar, Hernando, Reyes-Vargas, Eduardo, Delgado, Julio C, Welsh, Raymond M, Karow, Margaret L, Murphy, Andrew J, Valenzuela, David M, Yancopoulos, George D, Rock, Kenneth L

“…Immunoproteasomes incorporate three alternative β subunits that catalyze peptide cleavage. Rock and colleagues generate mice lacking all three…”
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Present Yourself! By MHC Class I and MHC Class II Molecules by Rock, Kenneth L, Reits, Eric, Neefjes, Jacques

“…Since the discovery of MHC molecules, it has taken 40 years to arrive at a coherent picture of how MHC class I and MHC class II molecules really work. This is…”
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Re-examining class-I presentation and the DRiP hypothesis by Rock, Kenneth L, Farfán-Arribas, Diego J, Colbert, Jeff D, Goldberg, Alfred L

“…Highlights • Class I-presented peptides may derive from normal functional protein and DRiPs. • The favored model posits that most peptides are derived from…”
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The Specificity of Trimming of MHC Class I-Presented Peptides in the Endoplasmic Reticulum by Hearn, Arron, York, Ian A, Rock, Kenneth L

“…Aminopeptidases in the endoplasmic reticulum (ER) can cleave antigenic peptides and in so doing either create or destroy MHC class I-presented epitopes…”
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Proteases in MHC Class I Presentation and Cross-Presentation by Rock, Kenneth L, Farfan-Arribas, Diego J, Shen, Lianjun

“…Cells that have mutated their genes or are virally infected are a potential threat to a host. Consequently, the immune system has evolved mechanisms for CD8 T…”
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Analysis of RNA-binding protein IMP3 to predict metastasis and prognosis of renal-cell carcinoma: a retrospective study by Jiang, Zhong, Chu, Peigou G, Woda, Bruce A, Rock, Kenneth L, Liu, Qin, Hsieh, Chung-Cheng, Li, Cuizhen, Chen, Wengang, Duan, Hai Ou, McDougal, Scott, Wu, Chin-Lee

“…Distant metastasis is the main cause of death from renal-cell carcinoma, and the metastatic potential of tumours is often unpredictable. We aimed to…”
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