Search Results - "Rocho, Fernanda R"

Differential specificity of SARS-CoV-2 main protease variants on peptide versus protein-based substrates by Rocho, Fernanda R, Snipas, Scott J, Shamim, Anwar, Rut, Wioletta, Drag, Marcin, Montanari, Carlos A, Salvesen, Guy S

“…The SARS-CoV-2 main protease (M ) holds significant importance as a biological target in combating coronaviruses due to its importance in virus replication…”
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Nitrile-based peptoids as cysteine protease inhibitors by Alves, Luana, Santos, Deborah A., Cendron, Rodrigo, Rocho, Fernanda R., Matos, Thiago K.B., Leitão, Andrei, Montanari, Carlos A.

“…[Display omitted] Peptidomimetics of the class of dipeptidyl nitrile analog peptoids were synthesized as inhibitors of mammalian cysteine proteases of the…”
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Nitriles: an attractive approach to the development of covalent inhibitors by Bonatto, Vinícius, Lameiro, Rafael F, Rocho, Fernanda R, Lameira, Jerônimo, Leitão, Andrei, Montanari, Carlos A

“…Nitriles have broad applications in medicinal chemistry, with more than 60 small molecule drugs on the market containing the cyano functional group. In…”
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A patent review on cathepsin K inhibitors to treat osteoporosis (2011 - 2021) by Rocho, Fernanda R, Bonatto, Vinícius, Lameiro, Rafael F, Lameira, Jerônimo, Leitão, Andrei, Montanari, Carlos A

“…Cathepsin K (CatK) is a lysosomal cysteine protease and the predominant cathepsin expressed in osteoclasts, where it degrades the bone matrix. Hence, CatK is…”
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Predicting the Relative Binding Affinity for Reversible Covalent Inhibitors by Free Energy Perturbation Calculations by Bonatto, Vinícius, Shamim, Anwar, Rocho, Fernanda dos R, Leitão, Andrei, Luque, F. Javier, Lameira, Jerônimo, Montanari, Carlos A

“…Covalent inhibitors are assuming central importance in drug discovery projects, especially in this pandemic scenario. Many research groups have focused their…”
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