Search Results - "Roche, Sarah"

Total protein analysis as a reliable loading control for quantitative fluorescent Western blotting by Eaton, Samantha L, Roche, Sarah L, Llavero Hurtado, Maica, Oldknow, Karla J, Farquharson, Colin, Gillingwater, Thomas H, Wishart, Thomas M

“…Western blotting has been a key technique for determining the relative expression of proteins within complex biological samples since the first publications in…”
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Progesterone Attenuates Microglial-Driven Retinal Degeneration and Stimulates Protective Fractalkine-CX3CR1 Signaling by Roche, Sarah L, Wyse-Jackson, Alice C, Gómez-Vicente, Violeta, Lax, Pedro, Ruiz-Lopez, Ana M, Byrne, Ashleigh M, Cuenca, Nicolás, Cotter, Thomas G

“…Retinitis pigmentosa (RP) is a degenerative disease leading to photoreceptor cell loss. Mouse models of RP, such as the rd10 mouse (B6.CXBl-Pde6brd10/J), have…”
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Microglial‐induced Müller cell gliosis is attenuated by progesterone in a mouse model of retinitis pigmentosa by Roche, Sarah L., Ruiz‐Lopez, Ana M., Moloney, Jennifer N., Byrne, Ashleigh M., Cotter, Thomas G.

“…Norgestrel, a progesterone analogue, has demonstrated neuroprotective effects in a mouse model of retinitis pigmentosa. Neuroprotection is achieved in part…”
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Norgestrel, a Progesterone Analogue, Promotes Significant Long-Term Neuroprotection of Cone Photoreceptors in a Mouse Model of Retinal Disease by Roche, Sarah L, Kutsyr, Oksana, Cuenca, Nicolás, Cotter, Thomas G

“…Retinitis pigmentosa (RP) refers to a group of inherited blinding retinal diseases, whereby the death of mutated rod photoreceptors is followed closely by the…”
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Migraine-attributed burden, impact and disability, and migraine-impacted quality of life: Expert consensus on definitions from a Delphi process by Steiner, Timothy J, Terwindt, Gisela M, Katsarava, Zaza, Pozo-Rosich, Patricia, Gantenbein, Andreas R, Roche, Sarah L, Dell'Agnello, Grazia, Tassorelli, Cristina

“…Migraine-attributed burden, impact, disability and migraine-impacted quality of life are important concepts in clinical management, clinical and…”
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SMN-dependent intrinsic defects in Schwann cells in mouse models of spinal muscular atrophy by Hunter, Gillian, Aghamaleky Sarvestany, Arwin, Roche, Sarah L, Symes, Rebecca C, Gillingwater, Thomas H

“…Low levels of survival of motor neuron (SMN) protein lead to spinal muscular atrophy (SMA). The major pathological hallmark of SMA is a loss of lower motor…”
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Dysregulation of ubiquitin homeostasis and β-catenin signaling promote spinal muscular atrophy by Wishart, Thomas M, Mutsaers, Chantal A, Riessland, Markus, Reimer, Michell M, Hunter, Gillian, Hannam, Marie L, Eaton, Samantha L, Fuller, Heidi R, Roche, Sarah L, Somers, Eilidh, Morse, Robert, Young, Philip J, Lamont, Douglas J, Hammerschmidt, Matthias, Joshi, Anagha, Hohenstein, Peter, Morris, Glenn E, Parson, Simon H, Skehel, Paul A, Becker, Thomas, Robinson, Iain M, Becker, Catherina G, Wirth, Brunhilde, Gillingwater, Thomas H

“…The autosomal recessive neurodegenerative disease spinal muscular atrophy (SMA) results from low levels of survival motor neuron (SMN) protein; however, it is…”
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Fractalkine-CX3CR1 signaling is critical for progesterone-mediated neuroprotection in the retina by Roche, Sarah L., Wyse-Jackson, Alice C., Ruiz-Lopez, Ana M., Byrne, Ashleigh M., Cotter, Thomas G.

“…Retinitis pigmentosa (RP) encompasses a group of retinal diseases resulting in photoreceptor loss and blindness. We have previously shown in the rd10 mouse…”
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Alterations to retinal architecture prior to photoreceptor loss in a mouse model of retinitis pigmentosa by Roche, Sarah L, Wyse-Jackson, Alice C, Byrne, Ashleigh M, Ruiz-Lopez, Ana M, Cotter, Thomas G

“…Mouse models of retinitis pigmentosa (RP) are essential tools in the pursuit to understand fully what cell types and processes underlie the degeneration…”
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Rod Photoreceptor Neuroprotection in Dark-Reared Pde6brd10 Mice by Berkowitz, Bruce A, Podolsky, Robert H, Childers, Karen Lins, Roche, Sarah L, Cotter, Thomas G, Graffice, Emma, Harp, Lamis, Sinan, Kenan, Berri, Ali M, Schneider, Michael, Qian, Haohua, Gao, Shasha, Roberts, Robin

“…The purpose of this study was to test the hypothesis that anti-oxidant and / or anti-inflammation drugs that suppress rod death in cyclic light-reared…”
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Cell Death Analysis in Retinal Cultures by Roche, Sarah L, Ruiz-Lopez, Ana M, Cotter, Thomas G

“…Evaluating cell death is essential when investigating neurodegeneration and neuroprotection in the retina. Cell death assays provide us with a means to…”
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Progesterone receptor signalling in retinal photoreceptor neuroprotection by Wyse Jackson, Alice C., Roche, Sarah L., Byrne, Ashleigh M., Ruiz‐Lopez, Ana M., Cotter, Thomas G.

“…‘Norgestrel’, a synthetic form of the female hormone progesterone has been identified as potential drug candidate for the treatment of the degenerative eye…”
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Pro‐survival redox signalling in progesterone‐mediated retinal neuroprotection by Ruiz Lopez, Ana M., Roche, Sarah L., Wyse Jackson, Alice C., Moloney, Jennifer N., Byrne, Ashleigh M., Cotter, Thomas G., Mallucci, Giovanna

“…Retinitis pigmentosa (RP) is a group of hereditary retinal diseases, characterised by photoreceptor cell loss. Despite a substantial understanding of the…”
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Selective Histone Deacetylase 6 Inhibitors Restore Cone Photoreceptor Vision or Outer Segment Morphology in Zebrafish and Mouse Models of Retinal Blindness by Sundaramurthi, Husvinee, Roche, Sarah L, Grice, Guinevere L, Moran, Ailis, Dillion, Eugene T, Campiani, Giuseppe, Nathan, James A, Kennedy, Breandán N

“…Blindness arising from retinal or macular degeneration results in significant social, health and economic burden. While approved treatments exist for…”
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Progesterone analogue protects stressed photoreceptors via bFGF-mediated calcium influx by Wyse-Jackson, Alice C., Roche, Sarah L., Ruiz-Lopez, Ana M., Moloney, Jennifer N., Byrne, Ashleigh M., Cotter, Thomas G.

“…Retinitis pigmentosa (RP) is a degenerative retinal disease leading to photoreceptor cell loss. In 2011, our group identified the synthetic progesterone…”
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A peer-volunteer led active ageing programme to prevent decline in physical function in older people at risk of mobility disability (Active, Connected, Engaged [ACE]): study protocol for a randomised controlled trial by Stathi, Afroditi, Withall, Janet, Crone, Diane, Hawley-Hague, Helen, Playle, Rebecca, Frew, Emma, Fenton, Sally, Hillsdon, Melvyn, Pugh, Christopher, Todd, Chris, Jolly, Kate, Cavill, Nick, Western, Max, Roche, Sarah, Kirby, Nigel, Boulton, Elisabeth, Thompson, Janice, Chatwin, Katie, Davies, Amy, Szekeres, Zsofia, Greaves, Colin

“…BackgroundThe Active Connected Engaged [ACE] study is a multi-centre, pragmatic, two-arm, parallel-group randomised controlled trial [RCT] with an internal…”
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The synthetic progestin norgestrel acts to increase LIF levels in the rd10 mouse model of retinitis pigmentosa by Byrne, Ashleigh M, Roche, Sarah L, Ruiz-Lopez, Ana M, Jackson, Alice C Wyse, Cotter, Thomas G

“…Retinal degenerative conditions affect thousands of people worldwide. Retinitis pigmentosa (RP) is among the most common, but it is currently incurable. It is…”
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The synthetic progestin norgestrel modulates Nrf2 signaling and acts as an antioxidant in a model of retinal degeneration by Byrne, Ashleigh M, Ruiz-Lopez, Ana M, Roche, Sarah L, Moloney, Jennifer N, Wyse-Jackson, Alice C, Cotter, Thomas G

“…Retinitis pigmentosa (RP) is one of the most common retinal degenerative conditions affecting people worldwide, and is currently incurable. It is characterized…”
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Loss of glial neurofascin155 delays developmental synapse elimination at the neuromuscular junction by Roche, Sarah L, Sherman, Diane L, Dissanayake, Kosala, Soucy, Geneviève, Desmazieres, Anne, Lamont, Douglas J, Peles, Elior, Julien, Jean-Pierre, Wishart, Thomas M, Ribchester, Richard R, Brophy, Peter J, Gillingwater, Thomas H

“…Postnatal synapse elimination plays a critical role in sculpting and refining neural connectivity throughout the central and peripheral nervous systems,…”
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A novel mouse model of Warburg Micro syndrome reveals roles for RAB18 in eye development and organisation of the neuronal cytoskeleton by Carpanini, Sarah M, McKie, Lisa, Thomson, Derek, Wright, Ann K, Gordon, Sarah L, Roche, Sarah L, Handley, Mark T, Morrison, Harris, Brownstein, David, Wishart, Thomas M, Cousin, Michael A, Gillingwater, Thomas H, Aligianis, Irene A, Jackson, Ian J

“…Mutations in RAB18 have been shown to cause the heterogeneous autosomal recessive disorder Warburg Micro syndrome (WARBM). Individuals with WARBM present with…”
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