Search Results - "Roche, Maike de la"

Primary Cilia Mediate Diverse Kinase Inhibitor Resistance Mechanisms in Cancer by Jenks, Andrew D., Vyse, Simon, Wong, Jocelyn P., Kostaras, Eleftherios, Keller, Deborah, Burgoyne, Thomas, Shoemark, Amelia, Tsalikis, Athanasios, de la Roche, Maike, Michaelis, Martin, Cinatl, Jindrich, Huang, Paul H., Tanos, Barbara E.

“…Primary cilia are microtubule-based organelles that detect mechanical and chemical stimuli. Although cilia house a number of oncogenic molecules (including…”
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Cell-autonomous Hedgehog signaling controls Th17 polarization and pathogenicity by Hanna, Joachim, Beke, Flavio, O’Brien, Louise M., Kapeni, Chrysa, Chen, Hung-Chang, Carbonaro, Valentina, Kim, Alexander B., Kishore, Kamal, Adolph, Timon E., Skjoedt, Mikkel-Ole, Skjoedt, Karsten, de la Roche, Marc, de la Roche, Maike

“…Th17 cells are key drivers of autoimmune disease. However, the signaling pathways regulating Th17 polarization are poorly understood. Hedgehog signaling…”
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Activation of the Hippo pathway by CTLA-4 regulates the expression of Blimp-1 in the CD8⁺ T cell by Thaventhiran, James E. D, Hoffmann, Anja, Magiera, Lukasz, de la Roche, Maike, Lingel, Holger, Brunner-Weinzierl, Monika, Fearon, Douglas T

“…During the primary response, the commitment of the CD8 ⁺ T cell to Blimp-1 expression and the terminal differentiation that Blimp-1 induces must be timed so as…”
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Publisher Correction: Novel immunotherapeutics against LGR5 to target multiple cancer types by Chen, Hung-Chang, Mueller, Nico, Stott, Katherine, Kapeni, Chrysa, Rivers, Eilidh, Sauer, Carolin M, Beke, Flavio, Walsh, Stephen J, Ashman, Nicola, O’Brien, Louise, Rafati Fard, Amir, Ghodsinia, Arman, Li, Changtai, Joud, Fadwa, Giger, Olivier, Zlobec, Inti, Olan, Ioana, Aitken, Sarah J, Hoare, Matthew, Mair, Richard, Serrao, Eva, Brenton, James D, Garcia-Gimenez, Alicia, Richardson, Simon E, Huntly, Brian, Spring, David R, Skjoedt, Mikkel-Ole, Skjødt, Karsten, de la Roche, Marc, de la Roche, Maike

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Centrosome docking at the immunological synapse is controlled by Lck signaling by Tsun, Andy, Qureshi, Ihjaaz, Stinchcombe, Jane C, Jenkins, Misty R, de la Roche, Maike, Kleczkowska, Joanna, Zamoyska, Rose, Griffiths, Gillian M

“…Docking of the centrosome at the plasma membrane directs lytic granules to the immunological synapse. To identify signals controlling centrosome docking at the…”
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Novel immunotherapeutics against LGR5 to target multiple cancer types by Chen, Hung-Chang, Mueller, Nico, Stott, Katherine, Kapeni, Chrysa, Rivers, Eilidh, Sauer, Carolin M, Beke, Flavio, Walsh, Stephen J, Ashman, Nicola, O’Brien, Louise, Rafati Fard, Amir, Ghodsinia, Arman, Li, Changtai, Joud, Fadwa, Giger, Olivier, Zlobec, Inti, Olan, Ioana, Aitken, Sarah J, Hoare, Matthew, Mair, Richard, Serrao, Eva, Brenton, James D, Garcia-Gimenez, Alicia, Richardson, Simon E, Huntly, Brian, Spring, David R, Skjoedt, Mikkel-Ole, Skjødt, Karsten, de la Roche, Marc, de la Roche, Maike

“…We have developed and validated a highly specific, versatile antibody to the extracellular domain of human LGR5 (α-LGR5). α-LGR5 detects LGR5 overexpression in…”
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A cell-engineered system to assess tumor cell sensitivity to CD8+ T cell-mediated cytotoxicity by Nelson, Nadine, Lopez-Pelaez, Marta, Palazon, Asis, Poon, Edmund, De La Roche, Maike, Barry, Simon, Valge-Archer, Viia, Wilkinson, Robert W., Dovedi, Simon J., Smith, Paul D.

“…In vitro assays that evaluate CD8 + T cell-mediated cytotoxicity are important to aid in the development of novel therapeutic approaches to enhance anti-tumor…”
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Hedgehog signalling in CD4+ T helper cell polarisation by Hanna, Joachim, de la Roche, Maike

“…CD4+ T cells are critical in orchestrating immune responses against various pathogens and cancer but can also be drivers of autoimmune disease, allergy and…”
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A Recipe for Success by Roche, Maike

“…In this article, I aim to give some pieces of career advise for young immunologists based on my own experiences. In this article, I aim to give some pieces of…”
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Origins of the cytolytic synapse by de la Roche, Maike, Asano, Yukako, Griffiths, Gillian M.

“…Key Points Ordering the events that lead to the formation of the cytolytic synapse provides a better understanding of the molecular mechanisms that are…”
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Aging increases cell-to-cell transcriptional variability upon immune stimulation by Martinez-Jimenez, Celia Pilar, Eling, Nils, Chen, Hung-Chang, Vallejos, Catalina A., Kolodziejczyk, Aleksandra A., Connor, Frances, Stojic, Lovorka, Rayner, Timothy F., Stubbington, Michael J. T., Teichmann, Sarah A., de la Roche, Maike, Marioni, John C., Odom, Duncan T.

“…Aging is characterized by progressive loss of physiological and cellular functions, but the molecular basis of this decline remains unclear. We explored how…”
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Utilizing TAPBPR to promote exogenous peptide loading onto cell surface MHC I molecules by Ilca, F. Tudor, Neerincx, Andreas, Wills, Mark R., de la Roche, Maike, Boyle, Louise H.

“…The repertoire of peptides displayed at the cell surface by MHC I molecules is shaped by two intracellular peptide editors, tapasin and TAPBPR. While cell-free…”
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Hedgehog Signaling Controls T Cell Killing at the Immunological Synapse by de la Roche, Maike, Ritter, Alex T., Angus, Karen L., Dinsmore, Colin, Earnshaw, Charles H., Reiter, Jeremy F., Griffiths, Gillian M.

“…The centrosome is essential for cytotoxic T lymphocyte (CTL) function, contacting the plasma membrane and directing cytotoxic granules for secretion at the…”
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IL‐7‐dependent compositional changes within the γδ T cell pool in lymph nodes during ageing lead to an unbalanced anti‐tumour response by Chen, Hung‐Chang, Eling, Nils, Martinez‐Jimenez, Celia Pilar, O'Brien, Louise McNeill, Carbonaro, Valentina, Marioni, John C, Odom, Duncan T, de la Roche, Maike

“…How the age‐associated decline of immune function leads to increased cancer incidence is poorly understood. Here, we have characterised the cellular…”
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Sa1531: HEDGEHOG SIGNALING CONTROLS TH17 DIFFERENTIATION TO DRIVE INTESTINAL INFLAMMATION AND IS A DRUGGABLE TARGET FOR THE TREATMENT OF IBD by Hanna, Joachim, Beke, Flavio, O'Brien, Louise, Kapeni, Chrysa, Chen, Hung-Chang, Carbonaro, Valentina, Kim, Alexander, Kishore, Kamal, Adolph, Timon E., Skjoedt, Mikkel-Ole, Skjoedt, Karsten, Roche, Marc de la, Roche, Maike de la

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Functional Characterisation of Distinct Fibroblast Subtypes in Pancreatic Cancer by Cheng, Priscilla S.W., Henríquez, Joaquín Araos, Jihad, Muntadher, Li, Wenlong, Lloyd, Eloise G., Manansala, Judhell S., Mucciolo, Gianluca, Roche, Maike de la, Biffi, Giulia

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CELL-AUTONOMOUS HEDGEHOG SIGNALING CONTROLS TH17 DIFFERENTIATION TO DRIVE INTESTINAL INFLAMMATION AND IS A DRUGGABLE TARGET FOR THE TREATMENT OF INFLAMMATORY BOWEL DISEASE by Hanna, Joachim, Beke, Flavio, O'Brien, Louise, Kapeni, Chrysa, Chen, Hung-Chang, Carbonaro, Valentina, Kim, Alexander, Adolph, Timon E., Skjoedt, Mikkel-Ole, Karsten, Skjoedt, Roche, Marc de la, Roche, Maike de la

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CELL-AUTONOMOUS HEDGEHOG SIGNALING CONTROLS TH17 DIFFERENTIATION TO DRIVE INTESTINAL INFLAMMATION AND IS A DRUGGABLE TARGET FOR THE TREATMENT OF INFLAMMATORY BOWEL DISEASE by Hanna, Joachim, Beke, Flavio, O’Brien, Louise, Kapeni, Chrysa, Chen, Hung-Chang, Carbonaro, Valentina, Kim, Alexander, Adolph, Timon E, Skjoedt, Mikkel-Ole, Karsten, Skjoedt, de la Roche, Marc, de la Roche, Maike

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A novel Atg5-shRNA mouse model enables temporal control of Autophagy in vivo by Cassidy, Liam D., Young, Andrew RJ, Pérez-Mancera, Pedro A., Nimmervoll, Birgit, Jaulim, Adil, Chen, Hung-Chang, McIntyre, Dominick J. O., Brais, Rebecca, Ricketts, Thomas, Pacey, Simon, De La Roche, Maike, Gilbertson, Richard J., Rubinsztein, David C., Narita, Masashi

“…Macroautophagy/autophagy is an evolutionarily conserved catabolic pathway whose modulation has been linked to diverse disease states, including age-associated…”
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Activation of the Hippo pathway by CTLA-4 regulates the expression of Blimp-1 in the CD8⁺ T cell by Thaventhiran, James E. D., Hoffmann, Anja, Magiera, Lukasz, de la Roche, Maike, Lingel, Holger, Brunner-Weinzierl, Monika, Fearon, Douglas T.

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