Search Results - "Roche, Katherine W."

Regulation of NMDA glutamate receptor functions by the GluN2 subunits by Vieira, Marta, Yong, Xuan Ling Hilary, Roche, Katherine W., Anggono, Victor

“…The N‐methyl‐D‐aspartate receptors (NMDARs) are ionotropic glutamate receptors that mediate the flux of calcium (Ca2+) into the post‐synaptic compartment. Ca2+…”
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Posttranslational regulation of AMPA receptor trafficking and function by Lu, Wei, Roche, Katherine W

“…Highlights ► AMPA receptor phosphorylation regulates receptor trafficking and function. ► AMPA receptor palmitoylation plays differential roles in receptor…”
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PSD-95 stabilizes NMDA receptors by inducing the degradation of STEP61 by Won, Sehoon, Incontro, Salvatore, Nicoll, Roger A., Roche, Katherine W.

“…Phosphorylation regulates surface and synaptic expression of NMDA receptors (NMDARs). Both the tyrosine kinase Fyn and the tyrosine phosphatase…”
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Cornichon Proteins Determine the Subunit Composition of Synaptic AMPA Receptors by Herring, Bruce E., Shi, Yun, Suh, Young Ho, Zheng, Chan-Ying, Blankenship, Sabine M., Roche, Katherine W., Nicoll, Roger A.

“…Cornichon-2 and cornichon-3 (CNIH-2/-3) are AMPA receptor (AMPAR) binding proteins that promote receptor trafficking and markedly slow AMPAR deactivation in…”
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Metabotropic glutamate receptor trafficking by Suh, Young Ho, Chang, Kai, Roche, Katherine W.

“…The metabotropic glutamate receptors (mGlu receptors) are G protein-coupled receptors that bind to the excitatory neurotransmitter glutamate and are important…”
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The CaMKII/NMDA receptor complex controls hippocampal synaptic transmission by kinase-dependent and independent mechanisms by Incontro, Salvatore, Díaz-Alonso, Javier, Iafrati, Jillian, Vieira, Marta, Asensio, Cedric S., Sohal, Vikaas S., Roche, Katherine W., Bender, Kevin J., Nicoll, Roger A.

“…CaMKII is one of the most studied synaptic proteins, but many critical issues regarding its role in synaptic function remain unresolved. Using a CRISPR-based…”
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mGluR5 and NMDA Receptors Drive the Experience- and Activity-Dependent NMDA Receptor NR2B to NR2A Subunit Switch by Matta, Jose A., Ashby, Michael C., Sanz-Clemente, Antonio, Roche, Katherine W., Isaac, John T.R.

“…In cerebral cortex there is a developmental switch from NR2B- to NR2A-containing NMDA receptors (NMDARs) driven by activity and sensory experience. This…”
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Regulation of NMDA receptors by phosphorylation by Chen, Bo-Shiun, Roche, Katherine W.

“…N-Methyl- d-aspartate (NMDA) receptors are critical for neuronal development and synaptic plasticity. The molecular mechanisms underlying the synaptic…”
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Autism Spectrum Disorder/Intellectual Disability-Associated Mutations in Trio Disrupt Neuroligin 1-Mediated Synaptogenesis by Tian, Chen, Paskus, Jeremiah D, Fingleton, Erin, Roche, Katherine W, Herring, Bruce E

“…We recently identified an autism spectrum disorder/intellectual disability (ASD/ID)-related mutation hotspot in the Rac1-activating GEF1 domain of the protein…”
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A Cluster of Autism-Associated Variants on X-Linked NLGN4X Functionally Resemble NLGN4Y by Nguyen, Thien A., Wu, Kunwei, Pandey, Saurabh, Lehr, Alexander W., Li, Yan, Bemben, Michael A., Badger, John D., Lauzon, Julie L., Wang, Tongguang, Zaghloul, Kareem A., Thurm, Audrey, Jain, Mahim, Lu, Wei, Roche, Katherine W.

“…Autism spectrum disorder (ASD) is more prevalent in males; however, the etiology for this sex bias is not well understood. Many mutations on X-linked cell…”
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Autonomous CaMKII Mediates Both LTP and LTD Using a Mechanism for Differential Substrate Site Selection by Coultrap, Steven J., Freund, Ronald K., O’Leary, Heather, Sanderson, Jennifer L., Roche, Katherine W., Dell’Acqua, Mark L., Bayer, K. Ulrich

“…Traditionally, hippocampal long-term potentiation (LTP) of synaptic strength requires Ca2+/calmodulin (CaM)-dependent protein kinase II (CaMKII) and other…”
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Posttranslational modifications of neuroligins regulate neuronal and glial signaling by Jeong, Jaehoon, Paskus, Jeremiah D, Roche, Katherine W

“…Highlights • NLGNs are regulated by multiple posttranslational modifications. • Posttranslational modifications allow isoform-specific NLGN functions. •…”
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GSG1L suppresses AMPA receptor-mediated synaptic transmission and uniquely modulates AMPA receptor kinetics in hippocampal neurons by Gu, Xinglong, Mao, Xia, Lussier, Marc P., Hutchison, Mary Anne, Zhou, Liang, Hamra, F. Kent, Roche, Katherine W., Lu, Wei

“…Regulation of AMPA receptor (AMPAR)-mediated synaptic transmission is a key mechanism for synaptic plasticity. In the brain, AMPARs assemble with a number of…”
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Advances in Proteomics Allow Insights Into Neuronal Proteomes by Fingleton, Erin, Li, Yan, Roche, Katherine W

“…Protein-protein interaction networks and signaling complexes are essential for normal brain function and are often dysregulated in neurological disorders…”
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Casein Kinase 2 Regulates the NR2 Subunit Composition of Synaptic NMDA Receptors by Sanz-Clemente, Antonio, Matta, Jose A., Isaac, John T.R., Roche, Katherine W.

“…N-methyl-D-aspartate (NMDA) receptors (NMDARs) play a central role in development, synaptic plasticity, and neurological disease. NMDAR subunit composition…”
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Support for the N-methyl-D-aspartate receptor hypofunction hypothesis of schizophrenia from exome sequencing in multiplex families by Timms, Andrew E, Dorschner, Michael O, Wechsler, Jeremy, Choi, Kyu Yeong, Kirkwood, Robert, Girirajan, Santhosh, Baker, Carl, Eichler, Evan E, Korvatska, Olena, Roche, Katherine W, Horwitz, Marshall S, Tsuang, Debby W

“…Schizophrenia is a complex genetic disorder demonstrating considerable heritability. Genetic studies have implicated many different genes and pathways, but…”
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Activated CaMKII Couples GluN2B and Casein Kinase 2 to Control Synaptic NMDA Receptors by Sanz-Clemente, Antonio, Gray, John A., Ogilvie, Kyle A., Nicoll, Roger A., Roche, Katherine W.

“…Synaptic activity triggers a profound reorganization of the molecular composition of excitatory synapses. For example, NMDA receptors are removed from synapses…”
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Activity-dependent ubiquitination of the AMPA receptor subunit GluA2 by Lussier, Marc P, Nasu-Nishimura, Yukiko, Roche, Katherine W

“…AMPA receptors (AMPARs) are postsynaptic glutamate-gated ion channels that mediate fast excitatory neurotransmission in the mammalian brain. Synaptic activity…”
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Isoform-specific cleavage of neuroligin-3 reduces synapse strength by Bemben, Michael A., Nguyen, Thien A., Li, Yan, Wang, Tongguang, Nicoll, Roger A., Roche, Katherine W.

“…The assembly and maintenance of synapses are dynamic processes that require bidirectional contacts between the pre- and postsynaptic structures. A network of…”
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CaMKII phosphorylation of neuroligin-1 regulates excitatory synapses by Bemben, Michael A, Shipman, Seth L, Hirai, Takaaki, Herring, Bruce E, Li, Yan, Badger, John D, Nicoll, Roger A, Diamond, Jeffrey S, Roche, Katherine W

“…This study shows that neuroligin-1, a trans-synaptic cell adhesion molecule for excitatory synapses, is directly phosphorylated by Ca 2+ /CaM kinase II in a…”
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