Search Results - "Roche, H. M."

Conjugated linoleic acid and inflammatory cell signalling by Reynolds, C.M, Roche, H.M

“…Abstract Conjugated linoleic acids (CLA) are a family of polyunsaturated fatty acids (PUFA), some isomers occurring naturally in beef and dairy products and…”
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Low serum cholesteryl ester-docosahexaenoic acid levels in Alzheimer's disease: a case–control study by Tully, A. M., Roche, H. M., Doyle, R., Fallon, C., Bruce, I., Lawlor, B., Coakley, D., Gibney, M. J.

“…Low n-3 polyunsaturated fatty acid (PUFA) status may be associated with neuro-degenerative disorders, in particular Alzheimer's disease, which has been…”
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Effects of dietary fat modification on insulin sensitivity and on other risk factors of the metabolic syndrome--LIPGENE: a European randomized dietary intervention study by Tierney, A.C, McMonagle, J, Shaw, D.I, Gulseth, H.L, Helal, O, Saris, W.H.M, Paniagua, J.A, Gołabek-Leszcyñska, I, Defoort, C, Williams, C.M, Karsltröm, B, Vessby, B, Dembinska-Kiec, A, López-Miranda, J, Blaak, E.E, Drevon, C.A

“…Background: Excessive energy intake and obesity lead to the metabolic syndrome (MetS). Dietary saturated fatty acids (SFAs) may be particularly detrimental on…”
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Leucocytosis in women with polycystic ovary syndrome (PCOS) is incompletely explained by obesity and insulin resistance by Phelan, N., O'Connor, A., Kyaw Tun, T., Correia, N., Boran, G., Roche, H. M., Gibney, J.

“…Summary Objectives Low‐grade chronic inflammation predicts cardiovascular outcomes and is observed in women with polycystic ovary syndrome (PCOS). Whether this…”
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High-Molecular-Weight Adiponectin Is Selectively Reduced in Women with Polycystic Ovary Syndrome Independent of Body Mass Index and Severity of Insulin Resistance by O'Connor, A, Phelan, N, Tun, T. Kyaw, Boran, G, Gibney, J, Roche, H. M

“…Context: High-molecular-weight (HMW) adiponectin contributes to insulin resistance (IR), which is closely associated with the pathophysiology of polycystic…”
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Identification of a plasma signature of psychotic disorder in children and adolescents from the Avon Longitudinal Study of Parents and Children (ALSPAC) cohort by O'Gorman, A, Suvitaival, T, Ahonen, L, Cannon, M, Zammit, S, Lewis, G, Roche, H M, Mattila, I, Hyotylainen, T, Oresic, M, Brennan, L, Cotter, D R

“…The identification of an early biomarker of psychotic disorder is important as early treatment is associated with improved patient outcome. Metabolomic and…”
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effects of conjugated linoleic acid supplementation on immune function in healthy volunteers by Nugent, A.P, Roche, H.M, Noone, E.J, Long, A, Kelleher, D.K, Gibney, M.J

“…Objective: To assess the effects of dietary supplementation using two isomeric blends of conjugated linoleic acid (CLA) on immune function in healthy human…”
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Pleiotropic effects of TCF7L2 gene variants and its modulation in the metabolic syndrome: From the LIPGENE study by Delgado-Lista, J, Perez-Martinez, P, García-Rios, A, Phillips, C.M, Williams, C.M, Gulseth, H.L, Helal, O, Blaak, E.E, Kiec-Wilk, B, Basu, S, Drevon, C.A, Defoort, C, Saris, W.H, Wybranska, I, Riserus, U, Lovegrove, J.A, Roche, H.M, Lopez-Miranda, J

“…Abstract Aims/hypothesis Variants of the TCF7L2 gene predict the development of type 2 diabetes mellitus (T2DM). We investigated the associations between gene…”
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Divergent mechanisms of cis9, trans11-and trans10, cis12-conjugated linoleic acid affecting insulin resistance and inflammation in apolipoprotein E knockout mice: a proteomics approach by Roos, B. de, Rucklidge, G, Reid, M, Ross, K, Duncan, G, Navarro, M. A, Arbones-Mainar, J. M, Guzman-Garcia, M. A, Osada, J, Browne, J, Loscher, C. E, Roche, H. M

“…ABSTRACTConjugated linoleic acids (CLA) affect atherogenesis, but mechanisms are not well understood. We explored how two isomers of CLA, cis9, trans11‐CLA and…”
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Effect of dietary supplementation with conjugated linoleic acid on markers of calcium and bone metabolism in healthy adult men by Doyle, L, Jewell, C, Mullen, A, Nugent, A.P, Roche, H.M, Cashman, K.D

“…Introduction: Conjugated linoleic acid (CLA) has been shown to positively influence calcium and bone metabolism in experimental animals and cells in culture,…”
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Effects of dietary fat modification on skeletal muscle fatty acid handling in the metabolic syndrome by Hees, A.M.J. van, Saris, W.H.M, Hul, G.B, Schaper, N.C, Timmerman, B.E, Lovegrove, J.A, Roche, H.M, Blaak, E.E

“…Objective: In the metabolic syndrome (MetS), increased fat storage in ‘nonadipose’ tissues such as skeletal muscle may be related to insulin resistance (‘lipid…”
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Effect of long-chain n-3 polyunsaturated fatty acids on fasting and postprandial triacylglycerol metabolism by ROCHE, H. M, GIBNEY, M. J

“…Elevated plasma triacylglycerol concentrations have been associated with increased risk of coronary heart disease (CHD). In the past, the epidemiologic…”
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Nutrition strategies to counteract sarcopenia: a focus on protein, LC n -3 PUFA, and precision nutrition by Murphy, C H, McCarthy, S N, Roche, H M

“…Diminished skeletal muscle strength and size, termed sarcopenia, contributes substantially to physical disability, falls, dependence and reduced quality of…”
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Inflammation and metabolism: the role of adiposity in sarcopenic obesity by Lynch, G. M., Murphy, C. H., Castro, E. de Marco, Roche, H. M.

“…Sarcopenic obesity is characterised by the double burden of diminished skeletal muscle mass and the presence of excess adiposity. From a mechanistic…”
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Oxylipin status, before and after LC n-3 PUFA supplementation, has little relationship with skeletal muscle biology in older adults at risk of sarcopenia by de Marco Castro, E., Kampschulte, N., Murphy, C.H., Schebb, N.H., Roche, H.M.

“…•At baseline, certain n-9 and n-6 hydroxy‑PUFA derived oxylipins [i.e., 5- and 12-HETrE, and 5- 11- and 16-HETE] were negatively correlated with markers of…”
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Clustering high‐dimensional mixed data to uncover sub‐phenotypes: joint analysis of phenotypic and genotypic data by McParland, D., Phillips, C. M., Brennan, L., Roche, H. M., Gormley, I. C.

“…The LIPGENE‐SU.VI.MAX study, like many others, recorded high‐dimensional continuous phenotypic data and categorical genotypic data. LIPGENE‐SU.VI.MAX focuses…”
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Fatty acids and epithelial permeability: effect of conjugated linoleic acid in Caco-2 cells by Roche, H M, Terres, A M, Black, I B, Gibney, M J, Kelleher, D

“…Conjugated linoleic acid (CLA) is a collective term referring to the positional and geometric isomers of linoleic acid. This novel fatty acid has been shown to…”
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Dietary lipids and gene expression by Roche, H M

“…Nutrition is a key environmental factor that is particularly involved in the pathogenesis and progression of several polygenic, diet-related diseases…”
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Nutrition and physical activity countermeasures for sarcopenia: Time to get personal? by Murphy, C. H., Roche, H. M.

“…Population ageing is a global phenomenon. It is regarded as a major cause of upward pressure on healthcare costs. One of the greatest threats to healthy,…”
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Increased intake of fruit and vegetables and a low-fat diet, with and without low-fat plant sterol-enriched spread consumption: effects on plasma lipoprotein and carotenoid metabolism by Colgan, H.A, Floyd, S, Noone, E.J, Gibney, M.J, Roche, H.M

“…Background  Regular intake of plant sterol (phytosterol)‐enriched foods enhances the cholesterol lowering effect of diets. One side effect associated with…”
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