Search Results - "Rocha Lima, Caio M"

Percutaneous Irreversible Electroporation for Downstaging and Control of Unresectable Pancreatic Adenocarcinoma by Narayanan, Govindarajan, MD, Hosein, Peter J., MD, Arora, Geetika, MD, Barbery, Katuzka J., MD, Froud, Tatiana, MD, Livingstone, Alan S., MD, Franceschi, Dido, MD, Rocha Lima, Caio M., MD, Yrizarry, Jose, MD

“…Abstract Purpose Treatment of unresectable locally advanced pancreatic cancer (LAPC) usually includes chemotherapy and/or radiation therapy in an attempt to…”
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A retrospective study of neoadjuvant FOLFIRINOX in unresectable or borderline-resectable locally advanced pancreatic adenocarcinoma by Hosein, Peter J, Macintyre, Jessica, Kawamura, Carolina, Maldonado, Jennifer Cudris, Ernani, Vinicius, Loaiza-Bonilla, Arturo, Narayanan, Govindarajan, Ribeiro, Afonso, Portelance, Lorraine, Merchan, Jaime R, Levi, Joe U, Rocha-Lima, Caio M

“…5-fluorouracil, leucovorin, irinotecan and oxaliplatin (FOLFIRINOX) is superior to gemcitabine in patients with metastatic pancreatic cancer who have a good…”
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Percutaneous Irreversible Electroporation for the Treatment of Colorectal Cancer Liver Metastases with a Proposal for a New Response Evaluation System by Hosein, Peter J., MD, Echenique, Ana, MD, Loaiza-Bonilla, Arturo, MD, Froud, Tatiana, MD, Barbery, Katuzka, MD, Rocha Lima, Caio M., MD, Yrizarry, Jose M., MD, Narayanan, Govindarajan, MD

“…Abstract Purpose To describe an initial experience with irreversible electroporation (IRE) in patients with colorectal liver metastasis (CLM). Materials and…”
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Phase II Trial of Sunitinib in Patients With Metastatic Colorectal Cancer After Failure of Standard Therapy by SALTZ, Leonard B, ROSEN, Lee S, XIN HUANG, DEPRIMO, Samuel E, CHOW-MANEVAL, Edna, CHAO, Richard C, LENZ, Heinz J, MARSHALL, John L, BELT, Robert J, HURWITZ, Herbert L, ECKHARDT, S. Gail, BERGSLAND, Emily K, HALLER, Daniel G, LOCKHART, A. Craig, ROCHA LIMA, Caio M

“…Sunitinib is an oral, multitargeted receptor tyrosine kinase inhibitor of the vascular endothelial growth factor receptor and multiple other growth factor…”
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A phase I dose-escalation trial of 2-deoxy-d-glucose alone or combined with docetaxel in patients with advanced solid tumors by Raez, Luis E., Papadopoulos, Kyriakos, Ricart, Alejandro D., Chiorean, E. Gabriella, DiPaola, Robert S., Stein, Mark N., Rocha Lima, Caio M., Schlesselman, James J., Tolba, Khaled, Langmuir, Virginia K., Kroll, Stewart, Jung, Donald T., Kurtoglu, Metin, Rosenblatt, Joseph, Lampidis, Theodore J.

“…Purpose This phase I trial was initiated to evaluate the safety, pharmacokinetics (PK) and maximum tolerated dose (MTD) of the glycolytic inhibitor, 2-deoxy- d…”
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Molecular basis and management of gastrointestinal stromal tumors by Bayraktar, Ulas D

“…Molecularly targeted agents have dramatically impacted the management of several cancers. Targeting KIT has led to a new treatment paradigm in gastrointestinal…”
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Percutaneous Image-Guided Irreversible Electroporation for the Treatment of Unresectable, Locally Advanced Pancreatic Adenocarcinoma by Narayanan, Govindarajan, MD, Hosein, Peter J., MD, Beulaygue, Isabelle C., PhD, Froud, Tatiana, MD, Scheffer, Hester J., MD, Venkat, Shree R., MD, Echenique, Ana M., MD, Hevert, Elizabeth C., MD, Livingstone, Alan S., MD, Rocha-Lima, Caio M., MD, Merchan, Jaime R., MD, Levi, Joseph U., MD, Yrizarry, Jose M., MD, Lencioni, Riccardo, MD

“…Abstract Purpose To describe safety and effectiveness of percutaneous irreversible electroporation (IRE) for treatment of unresectable, locally advanced…”
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A Phase II Trial of nab-Paclitaxel as Second-line Therapy in Patients With Advanced Pancreatic Cancer by HOSEIN, Peter J, DE LIMA LOPES, Gilberto, PASTORINI, Vitor H, GOMEZ, Christina, MACINTYRE, Jessica, ZAYAS, Gloria, REIS, Isildinha, MONTERO, Alberto J, MERCHAN, Jaime R, ROCHA LIMA, Caio M

“…nab-Paclitaxel has been shown to disrupt pancreatic cancer stroma and was effective in combination with gemcitabine in a phase I/II trial. This study was…”
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Irinotecan Plus Gemcitabine Results in No Survival Advantage Compared With Gemcitabine Monotherapy in Patients With Locally Advanced or Metastatic Pancreatic Cancer Despite Increased Tumor Response Rate by ROCHA LIMA, Caio M, GREEN, Mark R, ROTCHE, Robert, MILLER, Wilson H, JEFFREY, G. Mark, CISAR, Laura A, MORGANTI, Adele, ORLANDO, Nicoletta, GRUIA, Gabriela, MILLER, Langdon L

“…This phase III, randomized, open-label, multicenter study compared the overall survival associated with irinotecan plus gemcitabine (IRINOGEM) versus…”
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A phase 1 trial of E7974 administered on day 1 of a 21‐day cycle in patients with advanced solid tumors by Rocha‐Lima, Caio M., Bayraktar, Soley, MacIntyre, Jessica, Raez, Luis, Flores, Aurea M., Ferrell, Annapoorna, Rubin, Eric H., Poplin, Elizabeth A., Tan, Antoinette R., Lucarelli, Antonio, Zojwalla, Naseem

“…BACKGROUND: E7974, a synthetic analog of hemiasterlin, interacts with the tubulin molecule and overcomes resistance to other antitubulin drugs (taxanes and…”
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New directions in the management of advanced pancreatic cancer: a review by Rocha-Lima, Caio M

“…Complete surgical resection is the only potentially curative option for pancreatic cancer. However, most patients have advanced/metastatic disease at the time…”
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A cohort study evaluating the role of surgery for lung metastases from colorectal cancer by Socola, Francisco, Nguyen, Dao M, Ochoa, Roberto E, Rocha Lima, Caio M, Hosein, Peter J

“…Surgery may be curative in some patients with metastatic colorectal cancer (mCRC). We analyzed the role of lung metastatectomy in this population. In this…”
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DNA damage repair deficiency as a predictive biomarker for FOLFIRINOX efficacy in metastatic pancreatic cancer by Palacio, Sofia, McMurry, Hannah S, Ali, Robert, Donenberg, Talia, Silva-Smith, Rachel, Wideroff, Gina, Sussman, Daniel A, Rocha Lima, Caio M S, Hosein, Peter J

“…Patients with pathogenic germline and somatic variants in DNA damage repair (DDR) genes may derive greater benefit with platinum-based chemotherapy in…”
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Phase Ib Study of Drozitumab Combined With First-Line mFOLFOX6 Plus Bevacizumab in Patients with Metastatic Colorectal Cancer by Rocha Lima, Caio M., Bayraktar, Soley, Flores, Aurea M., MacIntyre, Jessica, Montero, Alberto, Baranda, Joaquina C., Wallmark, John, Portera, Chia, Raja, Rajiv, Stern, Howard, Royer-Joo, Stephanie, Amler, Lukas C.

“…In this multicenter phase Ib study, drozitumab was given in combination with the mFOLFOX6 regimen and bevacizumab in patients with previously untreated,…”
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The nab -paclitaxel/gemcitabine regimen for patients with refractory advanced pancreatic adenocarcinoma by Palacio, Sofia, Hosein, Peter J, Reis, Isildinha, Akunyili, Ikechukwu I, Ernani, Vinicius, Pollack, Terri, Macintyre, Jessica, Restrepo, Maria H, Merchan, Jaime R, Rocha Lima, Caio M

“…The phase III MPACT trial for metastatic pancreatic cancer (PC) showed improved overall survival (OS), progression free survival (PFS) and response rates (RRs)…”
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Advanced or Metastatic Pancreatic Cancer: Molecular Targeted Therapies by Bayraktar, Soley, Rocha‐Lima, Caio M.

“…Patients with pancreatic cancer normally present with advanced disease that is lethal and notoriously difficult to treat. However, clinical developments over…”
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Full dose neoadjuvant FOLFIRINOX is associated with prolonged survival in patients with locally advanced pancreatic adenocarcinoma by Khushman, Moh'd, Dempsey, Naomi, Cudris Maldonado, Jennifer, Loaiza-Bonilla, Arturo, Velez, Michel, Carcas, Lauren, Dammrich, Daniel, Hurtado-Cordovi, Jorge, Parajuli, Ritesh, Pollack, Terri, Harwood, Ana P, Macintyre, Jessica, Tzeng, Ching-Wei D, Merchan, Jaime R, Restrepo, Maria H, Akunyili, Ikechukwu I, Ribeiro, Afonso, Narayanan, Govindarajan, Portelance, Lorraine, Sleeman, Danny, Levi, Joe U, Rocha Lima, Caio M.S, Hosein, Peter J

“…Abstract Background The efficacy of FOLFIRINOX for metastatic pancreatic cancer has led to its use in patients with earlier stages of disease. This study…”
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EGFR targeting of solid tumors by Rocha-Lima, Caio M, Soares, Heloisa P, Raez, Luis E, Singal, Rakesh

“…Recent clinical trials suggest that epidermal growth factor receptor (EGFR)-targeted agents could benefit many patients with cancer. We review the current…”
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Severe colitis associated with docetaxel use:A report of four cases by Carrion, Andres F, Hosein, Peter J, Cooper, Eugene M, Lopes, Gilberto, Pelaez, Liset, Rocha-Lima, Caio M

“…Diarrhea is a common side effect of chemotherapy.Pseudomembranous colitis is a well known complication of antibiotic treatment that can also be observed,albeit…”
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Molecularly targeted therapies for advanced or metastatic non-small-cell lung carcinoma by Bayraktar, Soley, Rocha-Lima, Caio M

“…Non-small-cell lung cancer (NSCLC) remains the leading cause of cancer-related death in both men and women in the United States. Platinum-based doublet…”
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