Search Results - "Rocha‐Lima, Caio"

A retrospective study of neoadjuvant FOLFIRINOX in unresectable or borderline-resectable locally advanced pancreatic adenocarcinoma by Hosein, Peter J, Macintyre, Jessica, Kawamura, Carolina, Maldonado, Jennifer Cudris, Ernani, Vinicius, Loaiza-Bonilla, Arturo, Narayanan, Govindarajan, Ribeiro, Afonso, Portelance, Lorraine, Merchan, Jaime R, Levi, Joe U, Rocha-Lima, Caio M

“…5-fluorouracil, leucovorin, irinotecan and oxaliplatin (FOLFIRINOX) is superior to gemcitabine in patients with metastatic pancreatic cancer who have a good…”
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Percutaneous Irreversible Electroporation for Downstaging and Control of Unresectable Pancreatic Adenocarcinoma by Narayanan, Govindarajan, MD, Hosein, Peter J., MD, Arora, Geetika, MD, Barbery, Katuzka J., MD, Froud, Tatiana, MD, Livingstone, Alan S., MD, Franceschi, Dido, MD, Rocha Lima, Caio M., MD, Yrizarry, Jose, MD

“…Abstract Purpose Treatment of unresectable locally advanced pancreatic cancer (LAPC) usually includes chemotherapy and/or radiation therapy in an attempt to…”
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Full dose neoadjuvant FOLFIRINOX is associated with prolonged survival in patients with locally advanced pancreatic adenocarcinoma by Khushman, Moh'd, Dempsey, Naomi, Cudris Maldonado, Jennifer, Loaiza-Bonilla, Arturo, Velez, Michel, Carcas, Lauren, Dammrich, Daniel, Hurtado-Cordovi, Jorge, Parajuli, Ritesh, Pollack, Terri, Harwood, Ana P, Macintyre, Jessica, Tzeng, Ching-Wei D, Merchan, Jaime R, Restrepo, Maria H, Akunyili, Ikechukwu I, Ribeiro, Afonso, Narayanan, Govindarajan, Portelance, Lorraine, Sleeman, Danny, Levi, Joe U, Rocha Lima, Caio M.S, Hosein, Peter J

“…Abstract Background The efficacy of FOLFIRINOX for metastatic pancreatic cancer has led to its use in patients with earlier stages of disease. This study…”
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Percutaneous Image-Guided Irreversible Electroporation for the Treatment of Unresectable, Locally Advanced Pancreatic Adenocarcinoma by Narayanan, Govindarajan, MD, Hosein, Peter J., MD, Beulaygue, Isabelle C., PhD, Froud, Tatiana, MD, Scheffer, Hester J., MD, Venkat, Shree R., MD, Echenique, Ana M., MD, Hevert, Elizabeth C., MD, Livingstone, Alan S., MD, Rocha-Lima, Caio M., MD, Merchan, Jaime R., MD, Levi, Joseph U., MD, Yrizarry, Jose M., MD, Lencioni, Riccardo, MD

“…Abstract Purpose To describe safety and effectiveness of percutaneous irreversible electroporation (IRE) for treatment of unresectable, locally advanced…”
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A phase I dose-escalation trial of 2-deoxy-d-glucose alone or combined with docetaxel in patients with advanced solid tumors by Raez, Luis E., Papadopoulos, Kyriakos, Ricart, Alejandro D., Chiorean, E. Gabriella, DiPaola, Robert S., Stein, Mark N., Rocha Lima, Caio M., Schlesselman, James J., Tolba, Khaled, Langmuir, Virginia K., Kroll, Stewart, Jung, Donald T., Kurtoglu, Metin, Rosenblatt, Joseph, Lampidis, Theodore J.

“…Purpose This phase I trial was initiated to evaluate the safety, pharmacokinetics (PK) and maximum tolerated dose (MTD) of the glycolytic inhibitor, 2-deoxy- d…”
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A Gene Expression Model of Intrinsic Tumor Radiosensitivity: Prediction of Response and Prognosis After Chemoradiation by Eschrich, Steven A., Ph.D, Pramana, Jimmy, M.D, Zhang, Hongling, Ph.D, Zhao, Haiyan, B.S, Boulware, David, M.S, Lee, Ji-Hyun, Dr.Ph, Bloom, Gregory, Ph.D, Rocha-Lima, Caio, M.D, Kelley, Scott, M.D, Calvin, Douglas P., M.D, Yeatman, Timothy J., M.D, Begg, Adrian C., Ph.D, Torres-Roca, Javier F., M.D

“…Purpose Development of a radiosensitivity predictive assay is a central goal of radiation oncology. We reasoned a gene expression model could be developed to…”
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Irinotecan Plus Gemcitabine Results in No Survival Advantage Compared With Gemcitabine Monotherapy in Patients With Locally Advanced or Metastatic Pancreatic Cancer Despite Increased Tumor Response Rate by ROCHA LIMA, Caio M, GREEN, Mark R, ROTCHE, Robert, MILLER, Wilson H, JEFFREY, G. Mark, CISAR, Laura A, MORGANTI, Adele, ORLANDO, Nicoletta, GRUIA, Gabriela, MILLER, Langdon L

“…This phase III, randomized, open-label, multicenter study compared the overall survival associated with irinotecan plus gemcitabine (IRINOGEM) versus…”
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Percutaneous Irreversible Electroporation for the Treatment of Colorectal Cancer Liver Metastases with a Proposal for a New Response Evaluation System by Hosein, Peter J., MD, Echenique, Ana, MD, Loaiza-Bonilla, Arturo, MD, Froud, Tatiana, MD, Barbery, Katuzka, MD, Rocha Lima, Caio M., MD, Yrizarry, Jose M., MD, Narayanan, Govindarajan, MD

“…Abstract Purpose To describe an initial experience with irreversible electroporation (IRE) in patients with colorectal liver metastasis (CLM). Materials and…”
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Addition of Algenpantucel-L Immunotherapy to Standard Adjuvant Therapy for Pancreatic Cancer: a Phase 2 Study by Hardacre, Jeffrey M., Mulcahy, Mary, Small, William, Talamonti, Mark, Obel, Jennifer, Krishnamurthi, Smitha, Rocha-Lima, Caio S., Safran, Howard, Lenz, Heinz-Joseph, Chiorean, E. Gabriela

“…Background Despite continued investigation, limited progress has been made in the adjuvant treatment of resected pancreatic cancer. Novel or targeted therapies…”
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Does delay of adjuvant chemotherapy impact survival in patients with resected stage II and III colon adenocarcinoma? by Bayraktar, Ulas Darda, Chen, Emerson, Bayraktar, Soley, Sands, Laurence R., Marchetti, Floriano, Montero, Alberto Jose, Rocha‐Lima, Caio Max S.

“…BACKGROUND: It is unclear whether delays in commencing adjuvant chemotherapy after surgical resection of colon adenocarcinoma adversely impact survival…”
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New Therapeutic Directions for Advanced Pancreatic Cancer: Targeting the Epidermal Growth Factor and Vascular Endothelial Growth Factor Pathways by Burris, Howard, Rocha‐Lima, Caio

“…Learning Objectives After completing this course, the reader will be able to: Evaluate the existing chemotherapeutic options for advanced pancreatic cancer…”
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Phase II Trial of Sunitinib in Patients With Metastatic Colorectal Cancer After Failure of Standard Therapy by SALTZ, Leonard B, ROSEN, Lee S, XIN HUANG, DEPRIMO, Samuel E, CHOW-MANEVAL, Edna, CHAO, Richard C, LENZ, Heinz J, MARSHALL, John L, BELT, Robert J, HURWITZ, Herbert L, ECKHARDT, S. Gail, BERGSLAND, Emily K, HALLER, Daniel G, LOCKHART, A. Craig, ROCHA LIMA, Caio M

“…Sunitinib is an oral, multitargeted receptor tyrosine kinase inhibitor of the vascular endothelial growth factor receptor and multiple other growth factor…”
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A Phase II Trial of nab-Paclitaxel as Second-line Therapy in Patients With Advanced Pancreatic Cancer by HOSEIN, Peter J, DE LIMA LOPES, Gilberto, PASTORINI, Vitor H, GOMEZ, Christina, MACINTYRE, Jessica, ZAYAS, Gloria, REIS, Isildinha, MONTERO, Alberto J, MERCHAN, Jaime R, ROCHA LIMA, Caio M

“…nab-Paclitaxel has been shown to disrupt pancreatic cancer stroma and was effective in combination with gemcitabine in a phase I/II trial. This study was…”
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S3323 Acute Disseminated Intravascular Coagulation: A Rare Complication of Poorly Differentiated Esophageal Adenocarcinoma by Srivastav, Jigisha, Lima, Caio Rocha

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S438 Concomitant BRAF and RAS Mutations in Metastatic Colorectal Cancer by Srivastav, Jigisha, Lima, Caio Rocha

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A phase I clinical trial of navitoclax, a targeted high-affinity Bcl-2 family inhibitor, in combination with gemcitabine in patients with solid tumors by Cleary, James M., Lima, Caio Max S. Rocha, Hurwitz, Herbert I., Montero, Alberto J., Franklin, Catherine, Yang, Jianning, Graham, Alison, Busman, Todd, Mabry, Mack, Holen, Kyle, Shapiro, Geoffrey I., Uronis, Hope

“…Summary Purpose : To investigate the safety, optimal dosing, pharmacokinetics and clinical activity of a regimen of navitoclax (ABT-263) combined with…”
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A phase 1 trial of E7974 administered on day 1 of a 21‐day cycle in patients with advanced solid tumors by Rocha‐Lima, Caio M., Bayraktar, Soley, MacIntyre, Jessica, Raez, Luis, Flores, Aurea M., Ferrell, Annapoorna, Rubin, Eric H., Poplin, Elizabeth A., Tan, Antoinette R., Lucarelli, Antonio, Zojwalla, Naseem

“…BACKGROUND: E7974, a synthetic analog of hemiasterlin, interacts with the tubulin molecule and overcomes resistance to other antitubulin drugs (taxanes and…”
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Molecular basis and management of gastrointestinal stromal tumors by Bayraktar, Ulas D

“…Molecularly targeted agents have dramatically impacted the management of several cancers. Targeting KIT has led to a new treatment paradigm in gastrointestinal…”
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DNA damage repair deficiency as a predictive biomarker for FOLFIRINOX efficacy in metastatic pancreatic cancer by Palacio, Sofia, McMurry, Hannah S, Ali, Robert, Donenberg, Talia, Silva-Smith, Rachel, Wideroff, Gina, Sussman, Daniel A, Rocha Lima, Caio M S, Hosein, Peter J

“…Patients with pathogenic germline and somatic variants in DNA damage repair (DDR) genes may derive greater benefit with platinum-based chemotherapy in…”
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Advanced or Metastatic Pancreatic Cancer: Molecular Targeted Therapies by Bayraktar, Soley, Rocha‐Lima, Caio M.

“…Patients with pancreatic cancer normally present with advanced disease that is lethal and notoriously difficult to treat. However, clinical developments over…”
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