Search Results - "Rocha, Maria E.M."

Involvement of catalase in the apoptotic mechanism induced by apigenin in HepG2 human hepatoma cells by Valdameri, Glaucio, Trombetta-Lima, Marina, Worfel, Paulo R., Pires, Amanda R.A., Martinez, Glaucia R., Noleto, Guilhermina R., Cadena, Silvia M.S.C., Sogayar, Mari C., Winnischofer, Sheila M.B., Rocha, Maria E.M.

“…► Antioxidant enzymes in the apoptotic mechanism induced by apigenin in HepG2 cells. ► Catalase downregulation play an essential role in apigenin-induced…”
Get full text

Dual properties of hispidulin: antiproliferative effects on HepG2 cancer cells and selective inhibition of ABCG2 transport activity by Scoparo, Carina T., Valdameri, Glaucio, Worfel, Paulo R., Guterres, Fernanda A. L. B., Martinez, Glaucia R., Winnischofer, Sheila M. B., Di Pietro, Attilio, Rocha, Maria E. M.

“…Hepatocellular carcinoma is the third most common cause of cancer-related deaths worldwide. Furthermore, the existing pharmacological-based treatments are…”
Get full text

Oxidative damage to ferritin by 5-aminolevulinic acid by Rocha, Maria E.M, Dutra, Fernando, Bandy, Brian, Baldini, Regina L, Gomes, Suely L, Faljoni-Alário, Adelaide, Liria, Cleber W, Terêsa, M, Miranda, M, Bechara, Etelvino J.H

“…5-Aminolevulinic acid (ALA), a heme precursor overproduced in various porphyric disorders, has been implicated in iron-mediated oxidative damage to…”
Get full text

Roles of phosphate and an enoyl radical in ferritin iron mobilization by 5-aminolevulinic acid by Rocha, Maria E.M, Ferreira, Ana M.D.C, Bechara, Etelvino J.H

“…5-Aminolevulinic acid (ALA), a heme precursor that accumulates in acute intermittent porphyria (AIP) and lead poisoning, undergoes enolization and subsequent…”
Get full text

Investigation of Chalcones as Selective Inhibitors of the Breast Cancer Resistance Protein: Critical Role of Methoxylation in both Inhibition Potency and Cytotoxicity by Valdameri, Glaucio, Gauthier, Charlotte, Terreux, Raphaël, Kachadourian, Rémy, Day, Brian J, Winnischofer, Sheila M. B, Rocha, Maria E. M, Frachet, Véronique, Ronot, Xavier, Di Pietro, Attilio, Boumendjel, Ahcène

“…ABCG2 plays a major role in anticancer-drug efflux and related tumor multidrug resistance. Potent and selective ABCG2 inhibitors with low cytotoxicity were…”
Get full text

Substituted Chromones as Highly Potent Nontoxic Inhibitors, Specific for the Breast Cancer Resistance Protein by Valdameri, Glaucio, Genoux-Bastide, Estelle, Peres, Basile, Gauthier, Charlotte, Guitton, Jérôme, Terreux, Raphaël, Winnischofer, Sheila M. B, Rocha, Maria E. M, Boumendjel, Ahcène, Di Pietro, Attilio

“…A series of 13 disubstituted chromones was synthesized. Two types of substituents, on each side of the scaffold, contributed to both the potency of ABCG2…”
Get full text

Cytotoxicity of η-areneruthenium-based molecules to glioblastoma cells and their recognition by multidrug ABC transporters by Pazinato, Jaqueline, Cruz, Otávio M., Naidek, Karine P., Pires, Amanda R.A., Westphal, Eduard, Gallardo, Hugo, Baubichon-Cortay, Hélène, Rocha, Maria E.M., Martinez, Glaucia R., Winnischofer, Sheila M.B., Di Pietro, Attilio, Winnischofer, Herbert

Get full text

Cytotoxicity of η6-areneruthenium-based molecules to glioblastoma cells and their recognition by multidrug ABC transporters by Pazinato, Jaqueline, Cruz, Otávio M., Naidek, Karine P., Pires, Amanda R.A., Westphal, Eduard, Gallardo, Hugo, Baubichon-Cortay, Hélène, Rocha, Maria E.M., Martinez, Glaucia R., Winnischofer, Sheila M.B., Di Pietro, Attilio, Winnischofer, Herbert

“…A new series of amphiphilic η6-areneruthenium(II) compounds containing phenylazo ligands (group I: compounds 1a, 1b, 2a and 2b) and phenyloxadiazole ligands…”
Get full text

Methoxy Stilbenes as Potent, Specific, Untransported, and Noncytotoxic Inhibitors of Breast Cancer Resistance Protein by Valdameri, Glaucio, Pereira Rangel, Luciana, Spatafora, Carmela, Guitton, Jérôme, Gauthier, Charlotte, Arnaud, Ophélie, Ferreira-Pereira, Antonio, Falson, Pierre, Winnischofer, Sheila M. B, Rocha, Maria E. M, Tringali, Corrado, Di Pietro, Attilio

“…The ABCG2 multidrug transporter is known to confer cancer cell multidrug resistance by causing the efflux of anticancer drugs; therefore, selective inhibitors…”
Get full text

6-Halogenochromones Bearing Tryptamine: One-Step Access to Potent and Highly Selective Inhibitors of Breast Cancer Resistance Protein by Valdameri, Glaucio, Genoux-Bastide, Estelle, Gauthier, Charlotte, Peres, Basile, Terreux, Raphaël, Winnischofer, Sheila M. B., Rocha, Maria E. M., Di Pietro, Attilio, Boumendjel, Ahcène

“…Easy as A B C! 6‐Halochromone derivatives bearing a tryptamine moiety were evaluated as inhibitors of the breast cancer resistance protein (BCRP)/ABCG2. The…”
Get full text

Effect of flavonoids on 2′-deoxyguanosine and DNA oxidation caused by singlet molecular oxygen by Carneiro, Carlos D., Amorim, Juliana C., Cadena, Silvia M.S.C., Noleto, Guilhermina R., Di Mascio, Paolo, Rocha, Maria E.M., Martinez, Glaucia R.

“…Antioxidant potential is generally investigated by assaying the ability of a compound to protect biological systems from free radicals. However, non-radical…”
Get full text

Flavone induces cell death in human hepatoma HepG2 cells by Valdameri, Glaucio, Kenski, Juliana C N, Moure, Vivian R, Trombetta-Lima, Marina, Martinez, Glaucia R, Sogayar, Mari C, Winnischofer, Sheila M B, Rocha, Maria E M

“…Flavones have received considerable attention because of their antiproliferative properties and selective effects on cancer cells, making them good candidates…”
Get more information

Eupafolin: Effect on mitochondrial energetic metabolism by Herrerias, Tatiana, de Oliveira, Brás H., Gomes, Maria A.B., de Oliveira, Maria B.M., Carnieri, Eva G.S., Cadena, Sílvia M.S.C., Martinez, Glaucia R., Rocha, Maria E.M.

“…In this study the effects of eupafolin (6-methoxy 5,7,3′,4′-tetrahydroxyflavone), a flavone extracted from dry leaves of Eupatorium litoralle, on mitochondrial…”
Get full text

Effects of natural flavones on membrane properties and citotoxicity of HeLa cells by Herrerias, Tatiana, Oliveira, Alexandre A., Belem, Maurício L., Oliveira, Brás H., Carnieri, Eva G. S., Cadena, Sílvia M. S. C., Noleto, Guilhermina R., Martinez, Glaucia R., Oliveira, Maria B. M., Rocha, Maria E. M.

“…The aim of this study was to determine whether eupafolin and hispidulin, flavones extracted from Eupatorium littorale Cabrera, Asteraceae, have the ability to…”
Get full text

Sensitivities of the alternative respiratory components of potato tuber mitochondria to thiol reagents and Ca 2 by Mariano, André B., Valente, Caroline, Cadena, Silvia M.S.C., Rocha, Maria E.M., de Oliveira, Maria B.M., Carnieri, Eva G.S.

“…Plant mitochondria differ from those of mammals, since they incorporate an alternative electron transport pathway, which branches at ubiquinol to an…”
Get full text

Sensitivities of the alternative respiratory components of potato tuber mitochondria to thiol reagents and Ca2 by MARIANO, André B, VALENTE, Caroline, CADENA, Silvia M. S. C, ROCHA, Maria E. M, DE OLIVEIRA, Maria B. M, CARNIERI, Eva G. S

“…Plant mitochondria differ from those of mammals, since they incorporate an alternative electron transport pathway, which branches at ubiquinol to an…”
Get full text