Allogeneic mesenchymal stem cells and xenogenic platelet rich plasma, associated or not, in the repair of bone failures in rabbits with secondary osteoporosis

To assess the efficacy of allogeneic mesenchymal stem cells and xenogenic platelet rich plasma in the treatment of bone failure of osteoporotic rabbits secondary to estrogenic deprivation and iatrogenic hypercortisolism. Eight female rabbits underwent ovarian resection and corticoid therapy to induc...

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Published in:	Acta cirurgica brasileira Vol. 32; no. 9; pp. 767 - 780
Main Authors:	Rocha, Mariá Andrade de Carvalho, Silva, Laís Meireles Costa, Oliveira, Wellson Andrade de, Bezerra, Dayseanny de Oliveira, Silva, Gustavo Cardoso da, Silva, Lucilene Dos Santos, Medeiros, Brenda Lurian do Nascimento, Baêta, Sílvia de Araújo França, Carvalho, Maria Acelina Martins de, Argôlo, Neto, Napoleão Martins
Format:	Journal Article
Language:	English
Published:	Brazil Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia 01-09-2017
Subjects:	Animals Bone Regeneration - physiology Female Mesenchymal Stem Cell Transplantation Mesenchymal Stromal Cells Osteoporosis Osteoporosis - complications Platelet-Rich Plasma Rabbits Tibia - injuries Tibia - pathology Time Factors Transplantation, Heterologous
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Summary:	To assess the efficacy of allogeneic mesenchymal stem cells and xenogenic platelet rich plasma in the treatment of bone failure of osteoporotic rabbits secondary to estrogenic deprivation and iatrogenic hypercortisolism. Eight female rabbits underwent ovarian resection and corticoid therapy to induce clinical status of osteoporosis. Four failures were produced in the tibiae, with each failure being treated with hemostatic sponge, allogenic mesenchymal stem cells, xenogenic platelet-rich plasma and the association between both. The animals were divided into two groups, evaluated radiographically and histopathologically at 30 and 60 days post treatment. A radiographically confirmed consolidation of bone failures treated with allogeneic mesenchymal stem cells, associated with the histopathological image of mature and immature bone tissue, without evidence of osteopenia, was compared with the other groups, in which radiolucent failures with osteopenia and fibrosis were still present, denoting the satisfactory effect of the first treatment in detriment to the others. The treatment of bone failures of rabbits with secondary osteoporosis with allogeneic mesenchymal stem cells induced greater bone consolidation with mature and immature bone tissue production (p<0.01), when compared to the other treatments.
ISSN:	0102-8650 1678-2674
DOI:	10.1590/s0102-865020170090000009