Search Results - "Rocha, João BT"

Cross-generational trans fat intake modifies BDNF mRNA in the hippocampus: Impact on memory loss in a mania animal model by Trevizol, Fabíola, Dias, Verônica T., Roversi, Katiane, Barcelos, Raquel C.S., Kuhn, Fábio T., Roversi, Karine, Pase, Camila S., Golombieski, Ronaldo, Veit, Juliana C., Piccolo, Jaqueline, Emanuelli, Tatiana, Rocha, João B.T., Bürger, Marilise E.

“…ABSTRACT Recently, we have described the influence of dietary fatty acids (FA) on mania‐like behavior of first generation animals. Here, two sequential…”
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Toxicological effect of N, N, N′, N′-tetramethylethylene on rat brain acetylcholinesterase by Ahmed, Mushtaq, Latif, Nadia, Khan, Rahmat Ali, Ahmad, Akhlaq, Schetinger, Maria RC, Rocha, João BT

“…N, N, N′, N′-tetramethylethylenediamine (TEMED) is extensively used for initiating polymerization of acrylamide and bisacrylamide gel for electrophoresis and…”
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Dexmedetomidine protects blood δ-aminolevulinate dehydratase from inactivation caused by hyperoxygenation in total intravenous anesthesia by Rocha, João B T, Heinzmann Bulow, Neusa M, Correa, Eduardo F M, Scholze, Cassiano, Nogueira, Cristina W, Barbosa, Nilda B V

“…Delta-aminolevulinate dehydratase (δ-ALA-D) enzyme is sensitive to pro-oxidant agents, including molecular oxygen. Here, we tested whether hyperoxygenation…”
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Toxic metals that interact with thiol groups and alteration in insect behavior by Oliveira, Cláudia S, Nogara, Pablo A, Lima, Luíza S, Galiciolli, Maria EA, Souza, Júlia V, Aschner, Michael, Rocha, João BT

“…Toxic metals, such as mercury (Hg), lead (Pb), cadmium (Cd), and copper (Cu), are widespread in the biosphere, and human activities have contributed to their…”
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Dietary co-exposure to methylmercury and monosodium glutamate disrupts cellular and behavioral responses in the lobster cockroach, Nauphoeta cinerea model by Afolabi, Blessing A., Adedara, Isaac A., Souza, Diogo O., Rocha, João B.T.

“…•MeHg + MSG diet reduced total thiol levels in the experimental cockroaches.•TBARS level increased in cockroaches exposed to diet containing MeHg + MSG.•MeHg +…”
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Hydrogen Sulfide (H2S) Signaling as a Protective Mechanism against Endogenous and Exogenous Neurotoxicants by Aschner, Michael, Skalny, Anatoly V, Ke, Tao, da Rocha, Joao Bt, Paoliello, Monica Mb, Santamaria, Abel, Bornhorst, Julia, Rongzhu, Lu, Svistunov, Andrey A, Djordevic, Aleksandra B, Tinkov, Alexey A

“…In view of the significant role of H2S in brain functioning, it is proposed that H2S may also possess protective effects against adverse effects of…”
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Prenatal methylmercury exposure hampers glutathione antioxidant system ontogenesis and causes long-lasting oxidative stress in the mouse brain by Stringari, James, Nunes, Adriana K.C., Franco, Jeferson L., Bohrer, Denise, Garcia, Solange C., Dafre, Alcir L., Milatovic, Dejan, Souza, Diogo O., Rocha, João B.T., Aschner, Michael, Farina, Marcelo

“…During the perinatal period, the central nervous system (CNS) is extremely sensitive to metals, including methylmercury (MeHg). Although the mechanism(s)…”
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Mechanisms of methylmercury-induced neurotoxicity: Evidence from experimental studies by Farina, Marcelo, Rocha, João B.T., Aschner, Michael

“…Neurological disorders are common, costly, and can cause enduring disability. Although mostly unknown, a few environmental toxicants are recognized causes of…”
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Toxicology and pharmacology of selenium: emphasis on synthetic organoselenium compounds by Nogueira, Cristina W., Rocha, João B. T.

“…The advance in the area of synthesis and reactivity of organoselenium, as well as the discovery that selenium was the cause of severe intoxication episodes of…”
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Oxidative stress in MeHg-induced neurotoxicity by Farina, Marcelo, Aschner, Michael, Rocha, João B.T.

“…Methylmercury (MeHg) is an environmental toxicant that leads to long-lasting neurological and developmental deficits in animals and humans. Although the…”
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Antioxidant effect of organic purple grape juice on exhaustive exercise by Dalla Corte, Cristiane L, de Carvalho, Nélson R, Amaral, Guilherme P, Puntel, Gustavo O, Silva, Luiz Fernando A, Retamoso, Leandro T, Royes, Luiz Fernando F, Bresciani, Guilherme B, da Cruz, Ivana B M, Rocha, João B T, Barrio Lera, Juan Pablo, Soares, Félix A A

“…This study aimed to assess the potential protective effect of organic purple grape juice (PGJ) on oxidative stress produced by an exhaustive exercise bout in…”
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Cd modifies hepatic Zn deposition and modulates [delta]-ALA-D activity and MT levels by distinct mechanisms by Braga, Marcos Martins, Dick, Tuiskon, Oliveira, Diogo Losch, Guerra, Adriele Scopel, Leite, Marina Concli, Ardais, Ana Paula, Souza, Diogo Onofre, Rocha, João BT

“…Cadmium (Cd) is a pollutant that is harmful to human and animals. The liver is a target for Cd accumulation and it can disrupt Zn homeostasis. Here we examined…”
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Methylmercury and brain development: A review of recent literature by Antunes dos Santos, Alessandra, Appel Hort, Mariana, Culbreth, Megan, López-Granero, Caridad, Farina, Marcelo, Rocha, Joao B.T., Aschner, Michael

“…Methylmercury (MeHg) is a potent environmental pollutant, which elicits significant toxicity in humans. The central nervous system (CNS) is the primary target…”
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Diphenyl Diselenide Protects Against Mortality, Locomotor Deficits and Oxidative Stress in Drosophila melanogaster Model of Manganese-Induced Neurotoxicity by Adedara, Isaac A., Abolaji, Amos O., Rocha, Joao B. T., Farombi, Ebenezer O.

“…Several experimental and epidemiological reports have associated manganese exposure with induction of oxidative stress and locomotor dysfunctions. Diphenyl…”
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Neuroprotective mechanisms of selenium against arsenic-induced behavioral impairments in rats by Adedara, Isaac A., Fabunmi, Adekola T., Ayenitaju, Folashade C., Atanda, Oluwadarasimi E., Adebowale, Adetutu A., Ajayi, Babajide O., Owoeye, Olatunde, Rocha, Joao B.T., Farombi, Ebenezer O.

“…•Influence of Se on As-induced neurotoxicity was studied in rats.•Se abrogated As-mediated impairments in neurobehavioral activities in rats.•Se inhibited…”
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Long-term sucrose and glucose consumption decreases the [delta]-aminolevulinate dehydratase activity in mice by Brito, Verônica B, Folmer, Vanderlei, Soares, Júlio CM, Silveira, Ilson D, Rocha, João BT

“…Objective This study evaluated the long-term effects of high-glucose (GLU) and high-sucrose (SUC) diets on the development of obesity, abdominal fat…”
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Toxicity of ethylmercury (and Thimerosal): a comparison with methylmercury by Dórea, José G., Farina, Marcelo, Rocha, João B. T.

“…ABSTRACT Ethylmercury (etHg) is derived from the metabolism of thimerosal (o‐carboxyphenyl‐thio‐ethyl‐sodium salt), which is the most widely used form of…”
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REDOX MODULATION AT THE PERIPHERAL SITE ALTERS NOCICEPTIVE TRANSMISSION IN VIVO by Meotti, Flavia C, Coelho, Igor S, Franco, Jeferson L, Dafre, Alcir L, Rocha, João BT, Santos, Adair RS

“…SUMMARY 1 The aim of the present study was to investigate the role of redox modulation during the peripheral nociceptive transmission in vivo. The nociceptive…”
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Glia and Methylmercury Neurotoxicity by Ni, Mingwei, Li, Xin, Rocha, João B. T., Farina, Marcelo, Aschner, Michael

“…Methylmercury (MeHg) is a global environmental pollutant with significant adverse effects on human health. As the major target of MeHg, the central nervous…”
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Sex- and structure-specific differences in antioxidant responses to methylmercury during early development by Ruszkiewicz, Joanna A., Bowman, Aaron B., Farina, Marcelo, Rocha, João B.T., Aschner, Michael

“…•Sexual dimorphism in response to MeHg treatment was evident for TrxR, Trx and GPx.•Antioxidants were increased or unchanged in female brains, yet decreased in…”
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