Search Results - "Rocha, João B.T."

Mechanisms of methylmercury-induced neurotoxicity: Evidence from experimental studies by Farina, Marcelo, Rocha, João B.T., Aschner, Michael

“…Neurological disorders are common, costly, and can cause enduring disability. Although mostly unknown, a few environmental toxicants are recognized causes of…”
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Neural acetylcholinesterase and monoamine oxidase deregulation during streptozotocin-induced behavioral, metabolic and redox modification in Nauphoeta cinerea by Ogunsuyi, Opeyemi B, Olagoke, Olawande C, Famutimi, Mayokun E, Olatunde, Damilola M, Souza, Diogo O G, Oboh, Ganiyu, Barbosa, Nilda V, Rocha, João B T

“…Genetic and environmental factors have been linked with neurodegeneration, especially in the elderly. Yet, efforts to impede neurodegenerative processes have…”
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Neurobehavioral, neurotransmitter and redox modifications in Nauphoeta cinerea under mixed heavy metal (silver and mercury) exposure by Olagoke, Olawande C, Ogunsuyi, Opeyemi B, Mayokun, Famutimi E, Rocha, João B T, Oboh, Ganiyu

“…Heavy metals are encountered in nature, and are used in several human endeavors, including in dental fillings. It is well known that the safety of metals…”
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Prenatal methylmercury exposure hampers glutathione antioxidant system ontogenesis and causes long-lasting oxidative stress in the mouse brain by Stringari, James, Nunes, Adriana K.C., Franco, Jeferson L., Bohrer, Denise, Garcia, Solange C., Dafre, Alcir L., Milatovic, Dejan, Souza, Diogo O., Rocha, João B.T., Aschner, Michael, Farina, Marcelo

“…During the perinatal period, the central nervous system (CNS) is extremely sensitive to metals, including methylmercury (MeHg). Although the mechanism(s)…”
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Oxidative stress in MeHg-induced neurotoxicity by Farina, Marcelo, Aschner, Michael, Rocha, João B.T.

“…Methylmercury (MeHg) is an environmental toxicant that leads to long-lasting neurological and developmental deficits in animals and humans. Although the…”
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Diphenyl diselenide a janus-faced molecule by Nogueira, Cristina W, Rocha, João B.T

“…In this review, we summarized the potential role of synthetic organoseleno compounds as therapeutic or toxic agents, giving emphasis almost exclusively to…”
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Effects of 2,3-dimercapto-1-propanesulfonic acid (DMPS) on methylmercury-induced locomotor deficits and cerebellar toxicity in mice by Carvalho, Márcia C, Franco, Jeferson L, Ghizoni, Heloisa, Kobus, Karoline, Nazari, Evelise M, Rocha, João B.T, Nogueira, Cristina W, Dafre, Alcir L, Müller, Yara M.R, Farina, Marcelo

“…Abstract Chelating therapy has been reported as a useful approach for counteracting mercurial toxicity. Moreover, 2,3-dimercapto-1-propanesulfonic acid (DMPS),…”
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Antioxidant effect of organic purple grape juice on exhaustive exercise by Dalla Corte, Cristiane L, de Carvalho, Nélson R, Amaral, Guilherme P, Puntel, Gustavo O, Silva, Luiz Fernando A, Retamoso, Leandro T, Royes, Luiz Fernando F, Bresciani, Guilherme B, da Cruz, Ivana B M, Rocha, João B T, Barrio Lera, Juan Pablo, Soares, Félix A A

“…This study aimed to assess the potential protective effect of organic purple grape juice (PGJ) on oxidative stress produced by an exhaustive exercise bout in…”
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Post-translational modifications in MeHg-induced neurotoxicity by Ke, Tao, Gonçalves, Filipe Marques, Gonçalves, Cinara Ludvig, dos Santos, Alessandra Antunes, Rocha, João B.T., Farina, Marcelo, Skalny, Anatoly, Tsatsakis, Aristidis, Bowman, Aaron B., Aschner, Michael

“…Mercury (Hg) exposure remains a major public health concern due to its widespread distribution in the environment. Organic mercurials, such as MeHg, have been…”
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Oxidative stress, caspase-3 activation and cleavage of ROCK-1 play an essential role in MeHg-induced cell death in primary astroglial cells by dos Santos, Alessandra Antunes, López-Granero, Caridad, Farina, Marcelo, Rocha, João B.T., Bowman, Aaron B., Aschner, Michael

“…Methylmercury is a toxic environmental contaminant that elicits significant toxicity in humans. The central nervous system is the primary target of toxicity,…”
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Synthesis and biological evaluation of new nitrogen-containing diselenides by Nascimento, Vanessa, Ferreira, Natasha L., Canto, Rômulo F.S., Schott, Karen L., Waczuk, Emily P., Sancineto, Luca, Santi, Claudio, Rocha, João B.T., Braga, Antonio L.

“…The antioxidant properties of organoselenium compounds have been extensively investigated with the aim of developing new drugs, since oxidative stress is…”
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Novel aryl(heteroaryl)-substituted (pyrimidyl)benzamide-based BF2 complexes: Synthesis, photophysical properties, BSA-binding, and molecular docking analysis by Bonacorso, Helio G., Calheiro, Tainara P., Acunha, Thiago V., Iglesias, Bernardo A., Franceschini, Steffany Z., Ketzer, Alex, Meyer, Alexandre R., Nogara, Pablo A., Rocha, João B.T., Zanatta, Nilo, Martins, Marcos A.P.

“…This paper presents a new family of pyrimidine-based BF2 complexes. The series contains six examples of…”
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methylmercury- l-cysteine conjugate is a substrate for the L-type large neutral amino acid transporter by Yin, Zhaobao, Jiang, Haiyan, Syversen, Tore, Rocha, João B.T, Farina, Marcelo, Aschner, Michael

“…Methylmercury (MeHg) is a potent neurotoxin. The mechanism(s) that governs MeHg transport across the blood-brain barrier and other biological membranes remains…”
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Ovotoxicants 4-vinylcyclohexene 1,2-monoepoxide and 4-vinylcyclohexene diepoxide disrupt redox status and modify different electrophile sensitive target enzymes and genes in Drosophila melanogaster by Abolaji, Amos O, Kamdem, Jean P, Lugokenski, Thiago H, Farombi, Ebenezer O, Souza, Diogo O, da Silva Loreto, Élgion L, Rocha, João B T

“…The compounds 4-vinylcyclohexene 1,2-monoepoxide (VCM) and 4-Vinylcyclohexene diepoxide (VCD) are the two downstream metabolites of 4-vinylcyclohexene (VCH),…”
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Effect of dietary supplementation of Padauk ( Pterocarpus soyauxii ) leaf on high fat diet/streptozotocin induced diabetes in rats’ brain and platelets by Saliu, Jamiyu A, Oboh, Ganiyu, Omojokun, Olasunkanmi S, Rocha, João B.T, Schetinger, Maria R, Guterries, Jessie, Stefanello, Naiara, Carvalho, Fabiano, Schmatz, Roberta, Morsch, Vera M, Boligon, Aline

“…Abstract Background This study investigated the effects of Padauk leaf on brain malondialdehyde (MDA) content, acetylcholinesterase (AChE) activities,…”
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Oxidative Stress and Antioxidant Potential of One Hundred Medicinal Plants by Hassan, Waseem, Noreen, Hamsa, Rehman, Shakila, Gul, Shehnaz, Kamal, Mohammad Amjad, Kamdem, Jean Paul, Zaman, Bakht, da Rocha, Joao B T

“…Reactive species are produced in biological system because of redox reactions. The imbalance in pro-oxidant and antioxidant homeostasis leads to the production…”
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Methylmercury induces oxidative injury, alterations in permeability and glutamine transport in cultured astrocytes by Yin, Zhaobao, Milatovic, Dejan, Aschner, Judy L, Syversen, Tore, Rocha, Joao B.T, Souza, Diogo O, Sidoryk, Marta, Albrecht, Jan, Aschner, Michael

“…Abstract The neurotoxicity of high levels of methylmercury (MeHg) is well established both in humans and experimental animals. Astrocytes accumulate MeHg and…”
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Cytoprotective effect of Eugenia uniflora L. against the waste contaminant mercury chloride by Cunha, Francisco A.B., Pinho, Antonio I., Santos, Joycy F.S., Sobral-Souza, Celestina E., Albuquerque, Rosimeire S., Matias, Edinardo F.F., Leite, Nadghia F., Tintino, Saulo R., Costa, José G.M., Boligon, Aline A., Waczuk, Emily P., Rocha, João B.T., Posser, Thais, Coutinho, Henrique D.M., Quintans-Júnior, Lucindo J., Franco, Jeferson L.

“…Environmental stressors such as mercury are important for the search of substances to lower induced oxidative damage. Accordingly, secondary metabolites from…”
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Structure–activity relationship of flavonoids derived from medicinal plants in preventing methylmercury-induced mitochondrial dysfunction by Franco, Jeferson L, Posser, Thais, Missau, Fabiana, Pizzolatti, Moacir G, Santos, Adair R.S, Souza, Diogo O, Aschner, Michael, Rocha, João B.T, Dafre, Alcir L, Farina, Marcelo

“…Abstract In the present study, we investigated the potential protective effects of three flavonoids (myricetin, myricitrin and rutin) derived from medicinal…”
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Effects of Diphenyl Diselenide on Methylmercury Toxicity in Rats by da Rocha, João Batista Teixeira, Aschner, Michael, Busanello, Alcindo, Leite, Gerlania O., Comparsi, Bruna, Sudati, Jéssie H., Wagner, Caroline, Dalla Corte, Cristiane L., Soares, Félix A. A.

“…This study investigates the efficacy of diphenyl diselenide [(PhSe)2] in attenuating methylmercury- (MeHg-)induced toxicity in rats. Adult rats were treated…”
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