Search Results - "Rocha, Jefferson A."

Herbal Medicinal Products from Passiflora for Anxiety: An Unexploited Potential by Amaral, Ana Cláudia Fernandes, Ferreira, José Luiz P., da Cruz, Jefferson D., Ramos, Aline de S., Rodrigues, Rafaele de A., Fonseca, Lyca R. da, Silva, Jefferson Rocha de A.

“…Herbal medicines containing Passiflora species have been widely used to treat anxiety since ancient times. The species Passiflora incarnata L. is included in…”
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Computational quantum chemistry, molecular docking, and ADMET predictions of imidazole alkaloids of Pilocarpus microphyllus with schistosomicidal properties by Rocha, Jefferson A, Rego, Nayra C S, Carvalho, Bruna T S, Silva, Francisco I, Sousa, Jose A, Ramos, Ricardo M, Passos, Ionara N G, de Moraes, Josué, Leite, Jose R S A, Lima, Francisco C A

“…Schistosomiasis affects million people and its control is widely dependent on a single drug, praziquantel. Computational chemistry has led to the development…”
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Piper capitarianum essential oil: a promising insecticidal agent for the management of Aedes aegypti and Aedes albopictus by França, Leandro P., Amaral, Ana Claudia F., Ramos, Aline de S., Ferreira, José Luiz P., Maria, Ana Clara B., Oliveira, Kelson Mota T., Araujo, Earle S., Branches, Adjane Dalvana S., Silva, Jonathas N., Silva, Noam G., Barros, Gabriel de A., Chaves, Francisco Célio M., Tadei, Wanderli P., Silva, Jefferson Rocha de A.

“…Mosquitoes are responsible for serious public health problems worldwide, and as such, Aedes aegypti and Aedes albopictus are important vectors in the…”
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Alpinia Essential Oils and Their Major Components against Rhodnius nasutus, a Vector of Chagas Disease by Amaral, Ana Cláudia Fernandes, Queiroz, Margareth M. C., Silva, Jefferson Rocha de A., Ferreira, José Luiz P., Ramos, Aline de S., Lopes, Marcio B. P., Souza, Thamiris de A. de, Araújo, Kátia G. de Lima

“…Species of the genus Alpinia are widely used by the population and have many described biological activities, including activity against insects. In this…”
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Liposomal Formulation of Turmerone-Rich Hexane Fractions from Curcuma longa Enhances Their Antileishmanial Activity by Amaral, Ana Claudia F., Gomes, Luciana A., Silva, Jefferson Rocha de A., Ferreira, José Luiz P., Ramos, Aline de S., Rosa, Maria do Socorro S., Vermelho, Alane Beatriz, Rodrigues, Igor A.

“…Promastigote forms of Leishmania amazonensis were treated with different concentrations of two fractions of Curcuma longa cortex rich in turmerones and their…”
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A review of antimalarial plants used in traditional medicine in communities in Portuguese-speaking countries: Brazil, Mozambique, Cape Verde, Guinea-Bissau, São Tomé and Príncipe and Angola by Silva, Jefferson Rocha de A, Ramos, Aline de S, Machado, Marta, de Moura, Dominique F, Neto, Zoraima, Canto-Cavalheiro, Marilene M, Figueiredo, Paula, do Rosário, Virgilio E, Amaral, Ana Claudia F, Lopes, Dinora

“…The isolation of bioactive compounds from medicinal plants, based on traditional use or ethnomedical data, is a highly promising potential approach for…”
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In Vitro and In Vivo Studies of Spironolactone as an Antischistosomal Drug Capable of Clinical Repurposing by Guerra, Rafael A, Silva, Marcos P, Silva, Tais C, Salvadori, Maria C, Teixeira, Fernanda S, de Oliveira, Rosimeire N, Rocha, Jefferson A, Pinto, Pedro L S, de Moraes, Josué

“…Schistosomiasis is a parasitic flatworm disease that infects over 200 million people worldwide, especially in poor communities. Treatment and control of the…”
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Development of Nanoemulsions to Enhance the Antileishmanial Activity of Copaifera paupera Oleoresins by Amaral, Ana Cláudia Fernandes, Basso, Silvia L., Ferreira, José Luiz P., Falcão, Deborah Q., Ramos, Aline de S., Rodrigues, Igor A., Silva, Jefferson Rocha de A.

“…Based on the ethnopharmacological evidences about the antileishmanial activity of Copaifera spp. oleoresins, the effects of crude extracts and fractions of…”
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Diminazene aceturate inhibits the SARS-CoV-2 spike protein-induced inflammation involving leukocyte migration and DNA extracellular traps formation by Pereira-Silva, Gean C., Cornélio, Cassia K.C.A., Pacheco, Gabriella, Rochael, Natalia C., Gomes, Isaac A.B., Cajado, Aurilene G., Silva, Katriane C., Gonçalves, Barbara Simonson, Temerozo, Jairo R., Bastos, Ruan S., Rocha, Jefferson A., Souza, Leonardo P., Souza, Marcellus H.L.P., Lima-Júnior, Roberto C.P., Medeiros, Jand V.R., Filgueiras, Marcelo C., Bou-Habib, Dumith Chequer, Saraiva, Elvira M., Nicolau, Lucas A.D.

“…To investigate the SARS-CoV-2 Spike protein (Spk)-induced inflammatory response and its downmodulation by diminazene aceturate (DIZE). Through inducing Spk…”
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Antiviral potential of diminazene aceturate against SARS-CoV-2 proteases using computational and in vitro approaches by Santos, Esley S., Silva, Priscila C., Sousa, Paulo S.A., Aquino, Cristhyane C., Pacheco, Gabriella, Teixeira, Luiz F.L.S., Araujo, Alyne R., Sousa, Francisca B.M., Barros, Romulo O., Ramos, Ricardo M., Rocha, Jefferson A., Nicolau, Lucas A.D., Medeiros, Jand V.R.

“…Diminazene aceturate (DIZE), an antiparasitic, is an ACE2 activator, and studies show that activators of this enzyme may be beneficial for COVID-19, disease…”
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SARS-CoV-2 Spike protein triggers gut impairment since mucosal barrier to innermost layers: From basic science to clinical relevance by Nascimento, Renata R., Aquino, Cristhyane C., Sousa, José K., Gadelha, Kalinne L., Cajado, Aurilene G., Schiebel, Carolina S., Dooley, Sarah A, Sousa, Paulo A., Rocha, Jefferson A., Medeiros, Jand R., Magalhães, Pedro C., Maria-Ferreira, Daniele, Gois, Marcelo B., C. P. Lima-Junior, Roberto, V. T. Wong, Deysi, Lima, Aldo M., Engevik, Amy C., Nicolau, Lucas D., Vale, Mariana L.

“…•SARS-CoV-2 Spike protein (Spk) induces intestinal chloride secretion in mice.•Spk causes lysozyme depletion by Paneth cell degranulation.•Spk diminishes mucus…”
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Phenotypic screening of nonsteroidal anti-inflammatory drugs identified mefenamic acid as a drug for the treatment of schistosomiasis by Lago, Eloi M., Silva, Marcos P., Queiroz, Talita G., Mazloum, Susana F., Rodrigues, Vinícius C., Carnaúba, Paulo U., Pinto, Pedro L., Rocha, Jefferson A., Ferreira, Leonardo L.G., Andricopulo, Adriano D., de Moraes, Josué

“…Treatment and control of schistosomiasis, one of the most insidious and serious parasitic diseases, depend almost entirely on a single drug, praziquantel…”
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BR-bombesin: a novel bombesin-related peptide from the skin secretion of the Chaco tree frog (Boana raniceps) with physiological gastric effects by de Sousa, Nayara Alves, Marani, Mariela M., Lopes, André Luís Fernandes, Silva, Emanuelle Morais, Barbosa, Eder Alves, Vasconcelos, Andreanne Gomes, Kuzniewski, Felipe T. B., Lustosa, Suellen Sousa, Gomes, Karina Pereira, Colugnati, Diego Basile, Rocha, Jefferson A., Santos, Lucianna Helene, Benquerer, Marcelo P., Quelemes, Patrick, Véras, Leiz, Moreira, Daniel C., Gadelha, Kalinne Kelly Lima, Magalhães, Pedro Jorge Caldas, Plácido, Alexandra, Eaton, Peter, Nicolau, Lucas, Medeiros, Jand Venes R., Leite, José R. S. A.

“…Bombesin mediates several biological activities in the gastrointestinal (GI) tract and central nervous system in mammals, including smooth muscle contraction,…”
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Anthelmintic, Antibacterial and Cytotoxicity Activity of Imidazole Alkaloids from Pilocarpus microphyllus Leaves by Rocha, Jefferson A., Andrade, Ivanilza M., Véras, Leiz M.C., Quelemes, Patrick V., Lima, David F., Soares, Maria J.S., Pinto, Pedro L.S., Mayo, Simon J., Ivanova, Galya, Rangel, Maria, Correia, Manuela, Mafud, Ana Carolina, Mascarenhas, Yvonne P., Delerue‐Matos, Cristina, Moraes, Josué, Eaton, Peter, Leite, José R.S.A.

“…Pilocarpus microphyllus Stapf ex Wardlew (Rutaceae), popularly known as jaborandi, is a plant native to the northern and northeastern macroregions of Brazil…”
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Antiviral Action against SARS-CoV-2 of a Synthetic Peptide Based on a Novel Defensin Present in the Transcriptome of the Fire Salamander ( Salamandra salamandra ) by Barros, Ana Luisa A N, Silva, Vladimir C, Ribeiro-Junior, Atvaldo F, Cardoso, Miguel G, Costa, Samuel R, Moraes, Carolina B, Barbosa, Cecília G, Coleone, Alex P, Simões, Rafael P, Cabral, Wanessa F, Falcão, Raul M, Vasconcelos, Andreanne G, Rocha, Jefferson A, Arcanjo, Daniel D R, Batagin-Neto, Augusto, Borges, Tatiana Karla S, Gonçalves, João, Brand, Guilherme D, Freitas-Junior, Lucio H G, Eaton, Peter, Marani, Mariela, Kato, Massuo J, Plácido, Alexandra, Leite, José Roberto S A

“…The potential emergence of zoonotic diseases has raised significant concerns, particularly in light of the recent pandemic, emphasizing the urgent need for…”
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Identification of Phenolic Compounds and Evaluation of Antioxidant and Antimicrobial Properties of Euphorbia Tirucalli L by de Araújo, Keline Medeiros, de Lima, Alessandro, Silva, Jurandy do N, Rodrigues, Larissa L, Amorim, Adriany G N, Quelemes, Patrick V, Dos Santos, Raimunda C, Rocha, Jefferson A, de Andrades, Éryka O, Leite, José Roberto S A, Mancini-Filho, Jorge, da Trindade, Reginaldo Almeida

“…Bioactive compounds extracted from natural sources can benefit human health. The aim of this work was to determine total phenolic content and antioxidant…”
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An experimental design approach to obtain canthinone alkaloid-enriched extracts from Simaba aff. paraensis by Ramos, Aline de S., Ferreira, José Luiz P., Silva, Jefferson Rocha de A., da Cruz, Jefferson D., de Oliveira, Danielle L., Mpalantinos da Silva, Maria A., Basso, Silvia L., Amaral, Ana Claudia F.

“…The species of the genus Simaba (Simaroubaceae) are found in almost all Brazil and they are used by local population for the treatment of ulcers and malaria…”
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Chemical composition and biological activities of Bocageopsis multiflora essential oil by Oliveira, Edinilze S.C, Amaral, Ana Claudia F, Lima, Emerson S, Silva, Jefferson Rocha de A

“…This article describes, for the first time, the chemical constituents of the essential oils from fresh leaves of Bocageopsis multiflora , collected in two…”
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Hydroxylation of 1,8-cineole by Mucor ramannianus and Aspergillus niger by Ramos, Aline de Souza, Ribeiro, Joyce Benzaquem, Teixeira, Bruna Gomes, Ferreira, José Luiz Pinto, Silva, Jefferson Rocha de A, Ferreira, Alexandre do Amaral, de Souza, Rodrigo Octavio Mendonça Alves, Amaral, Ana Claudia F

“…The monoterpenoid 1,8-cineole is obtained from the leaves of Eucalyptus globulus and it has important biological activities. It is a cheap natural substrate…”
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Evaluation of Antiplasmodial activity of extracts and constituents from Ampelozizyphus amazonicus by do Carmo, Dominique F M, Amaral, Ana Claudia F, Machado, Marta, Lopes, Dinora, Echevarria, Aurea, Rosário, Virgílio E, Silva, Jefferson Rocha de A

“…Ampelozizyphus amazonicus Ducke, a plant that is widely used by the population of the Amazonian region to prevent and treat malaria, was investigated in this…”
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