Ex vivo evaluation of the percutaneous penetration of proanthocyanidin extracts from Guazuma ulmifolia using photoacoustic spectroscopy

Ex vivo evaluation of the percutaneous penetration of proanthocyanidin extracts from Guazuma ulmifolia using photoacoustic spectroscopy

In this work photoacoustic spectroscopy has been applied to determine ex vivo the percutaneous penetration of proanthocyanidins present in extracts obtained from Guazuma ulmifolia, in rats. Lotion formulations containing 0.0663 mg of procyanidin B2 day −1 animal −1 were topically applied during 7, 1...

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Bibliographic Details
Published in:Analytica chimica acta Vol. 587; no. 1; pp. 132 - 136
Main Authors: Rocha, J.C.B., Pedrochi, F., Hernandes, L., de Mello, J.C.P., Baesso, M.L.
Format: Journal Article
Language:English
Published: Amsterdam Elsevier B.V 21-03-2007
Elsevier
Subjects:
Acoustics
Administration, Cutaneous
Analytical chemistry
Animals
Chemistry
Emollients
Ex vivo measurements
Exact sciences and technology
Light
Male
Models, Chemical
Natural substances
Percutaneous penetration
Photoacoustic spectroscopy
Plant Extracts - analysis
Plant Extracts - pharmacokinetics
Plants - metabolism
Proanthocyanidins - analysis
Proanthocyanidins - chemistry
Rats
Rats, Wistar
Skin - drug effects
Spectrum Analysis - methods
Time Factors
Percutaneous penetration
Natural substances
Photoacoustic spectroscopy
Ex vivo measurements
Sample preparation
Optoacoustical spectrometry
Pharmacokinetics
Optical absorption
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Summary:In this work photoacoustic spectroscopy has been applied to determine ex vivo the percutaneous penetration of proanthocyanidins present in extracts obtained from Guazuma ulmifolia, in rats. Lotion formulations containing 0.0663 mg of procyanidin B2 day −1 animal −1 were topically applied during 7, 10 and 13 days in each group of the animals. After the end of treatment the animals were killed, the skin dissected to remove the basal content, and the measurements were carried out as a function of the period of time of treatment. The results showed that despite the very low concentration of the active principle (procyanidin B2) in the lotion, the photoacoustic method was able to show the presence of optical absorption bands from this substance in the dermis region, evidencing once again that this method may be useful for studies of topically applied formulations of interest in the pharmacokinetic area.
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ISSN:0003-2670
1873-4324
DOI:10.1016/j.aca.2007.01.002