Sonographic hepatorenal ratio: A noninvasive method to diagnose nonalcoholic steatosis

Purpose. To evaluate the accuracy of the sonographic hepatorenal ratio (HRR) in the diagnosis and grading of nonalcoholic steatosis, using biopsy as the reference. Methods. Ultrasound (US) and liver biopsy were performed in 42 patients with nonalcoholic fatty liver disease. Forty healthy volunteers...

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Published in:	Journal of clinical ultrasound Vol. 41; no. 1; pp. 18 - 25
Main Authors:	de Almeida e Borges, Valéria Ferreira, Diniz, Angélica L. D., Cotrim, Helma P., Rocha, Haroldo L. O. G., Andrade, Nestor Barbosa
Format:	Journal Article
Language:	English
Published:	Hoboken Wiley Subscription Services, Inc., A Wiley Company 01-01-2013 Wiley Subscription Services, Inc
Subjects:	Adult Aged Biopsy, Needle - methods Diagnosis, Differential fatty liver Fatty Liver - diagnostic imaging Fatty Liver - pathology Female Humans Liver - diagnostic imaging Liver - pathology liver biopsy Liver cirrhosis Liver diseases Male Middle Aged Non-alcoholic Fatty Liver Disease nonalcoholic steatosis Prospective Studies Reproducibility of Results ROC Curve Severity of Illness Index sonographic hepatorenal ratio Ultrasonic imaging Ultrasonography ultrasound
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Summary:	Purpose. To evaluate the accuracy of the sonographic hepatorenal ratio (HRR) in the diagnosis and grading of nonalcoholic steatosis, using biopsy as the reference. Methods. Ultrasound (US) and liver biopsy were performed in 42 patients with nonalcoholic fatty liver disease. Forty healthy volunteers without steatosis at US and without risk factors for nonalcoholic fatty liver disease were also studied. The HRR was obtained by dividing the mean brightness level of region‐of‐interest pixels in hepatic parenchyma by that in renal parenchyma. Needle biopsy samples (hematoxylin‐eosin stained) were classified as mild (5–33% fatty infiltration), moderate (>33–66%), or severe (>66%) steatosis. Spearman coefficient was used to evaluate the correlation between HRR and steatosis grade, analysis of variance for differences between subgroups, and receiver operating characteristic curve analysis for sensitivity and specificity. Results. Significant correlation was found between HRR and histologic steatosis (r = 0.80, p < 0.01). The HRR cutoff for predicting steatosis was ≥1.24 (sensitivity, 92.7%; specificity, 92.5%). The mean ± SD HRRs in controls and steatosis subgroups were control 1.09 ± 0.13, mild 1.46 ± 0.24, moderate 1.52 ± 0.27, severe 2.04 ± 0.3 and were significantly different from each other except between mild and moderate steatosis subgroups. Conclusions. The HRR is a noninvasive, objective, and simple method that could be used to diagnose and grade hepatic steatosis. © 2012 Wiley Periodicals, Inc. J Clin Ultrasound 2013
Bibliography:	ArticleID:JCU21994 istex:069341996F167EDE9FACE704CA1EB17BBD26B020 ark:/67375/WNG-SQ2J1CM0-8 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 ObjectType-Article-2 ObjectType-Feature-1
ISSN:	0091-2751 1097-0096
DOI:	10.1002/jcu.21994