Effects of ondansetron on respiratory pattern and sensation of experimentally induced dyspnea

Dyspnea remains a therapeutic challenge, especially in chronic respiratory conditions. Recent studies have shown that the induction of unpleasant dyspnea sensations activates areas in the insular cortex. This study was designed to investigate the potential effects of ondansetron, a potent anti-serot...

Full description

Saved in:

Bibliographic Details
Published in:	São Paulo medical journal Vol. 120; no. 5; pp. 141 - 145
Main Authors:	Martinez, José Antônio Baddini, Rocha, Fábio Senra, Sobrani, Elizabet, Galhardo, Fabíola Paula Lovreto, Terra Filho, João
Format:	Journal Article
Language:	English
Published:	Brazil Associação Paulista de Medicina - APM 02-09-2002 Associação Paulista de Medicina
Subjects:	Adult Analog Scale Double-Blind Method Dyspnea Dyspnea - drug therapy Humans Male MEDICINE, GENERAL & INTERNAL Ondansetron Ondansetron - therapeutic use Pulmonary Function Serotonin Antagonists - therapeutic use Spirometry Statistics, Nonparametric Escala Analógica Dyspnea Ondansetrona Analog Scale Ondansetron Pulmonary Function Dispnéia Função Pulmonar
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Dyspnea remains a therapeutic challenge, especially in chronic respiratory conditions. Recent studies have shown that the induction of unpleasant dyspnea sensations activates areas in the insular cortex. This study was designed to investigate the potential effects of ondansetron, a potent anti-serotonin agent, on induced dyspnea sensation. A randomized double blind study. Pulmonary Function Laboratory of Hospital das Clínicas de Ribeirão Preto. Ten healthy male volunteers (mean age +/- standard error = 23.1 +/- 0.41 years) without respiratory diseases and showing normal spirometric tests. Uncomfortable breathing was induced in the volunteers on two different days, via the use of inspiratory resistors (loads of 0, 7, 14 and 21 cm H2O/l/sec) and breathholding, two hours after taking 8 mg of ondansetron (Ond) or placebo (Plac). Respiratory discomfort during breathing under loading was evaluated on a 100-mm visual analog scale. The maximum length of time of voluntary apnea was measured in seconds. The mean maximum voluntary apnea time did not differ between the ondansetron and placebo days (Plac = 96 +/- 6.6 sec vs. Ond = 100 +/- 7.9 sec). Ondansetron did not influence the dyspnea sensation induced by different inspiratory loads (0 cm H2O/l/sec: Ond = 1.4 mm +/- 0.44 vs. Plac = 2.1 +/- 0.85 mm; 7 cm H2O/l/sec: Ond = 16.6 +/- 2.74 mm vs. Plac = 13.7 +/- 2.06 mm; 14 cm H2O/l/sec; Ond = 30.5 +/- 4.50 mm vs. Plac = 27.1 +/- 3.44 mm; 21 cm H2O/l/sec: Ond = 50.3 +/- 6.72 mm vs. Plac = 49.4 +/- 6.72 mm). Ondansetron led to significant decreases in tidal volume under basal conditions and when breathing under the highest inspiratory loading (0 cm H2O/l/sec: Ond = 0.83 +/- 0.26 l vs. Plac = 1.0 +/- 0.28 l; 21 cm H2O/l/sec: Ond = 0.86 +/- 0.23 l vs. Plac = 1.1 +/- 0.22 l) The present results suggest that 5-HT3 receptors do not play an important role in the mediation of dyspnea sensations.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 ObjectType-News-3 content type line 23
ISSN:	1516-3180 1806-9460 1516-3180
DOI:	10.1590/s1516-31802002000500004