Low serum lycopene, and adequate α-tocopherol levels in patients with psoriasis: A cross-sectional study

Low serum lycopene, and adequate α-tocopherol levels in patients with psoriasis: A cross-sectional study

Background: Psoriasis is a chronic, immune-mediated skin disease. It affects skin and joints, characterized by abnormal hyperproliferation of keratinocytes. The worldwide prevalence of psoriasis ranges from 2% to 4%. Environmental factors as smoking, alcohol consumption obesity can also work as trig...

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Published in:Nutrition and health (Berkhamsted) Vol. 28; no. 2; pp. 239 - 248
Main Authors: Rocha, Ana C L, Bortoletto, Maria C, da Costa, Andréia C, Oyafuso, Luiza K M, Sanudo, Adriana, Tomita, Luciana Y
Format: Journal Article
Language:English
Published: London, England SAGE Publications 01-06-2022
Subjects:
alpha-Tocopherol
Antioxidants
Chronic Disease
Cross-Sectional Studies
Diet
Eating
Female
Humans
Lycopene
Male
Obesity
Psoriasis - epidemiology
antioxidant
tocopherol
diet
Psoriasis
lycopene
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Summary:Background: Psoriasis is a chronic, immune-mediated skin disease. It affects skin and joints, characterized by abnormal hyperproliferation of keratinocytes. The worldwide prevalence of psoriasis ranges from 2% to 4%. Environmental factors as smoking, alcohol consumption obesity can also work as triggers. During the inflammatory process, there is an exacerbated formation of free radicals and antioxidants are required to maintain redox balance. Aim: Assess antioxidant profiles. Methods: A cross-sectional study was conducted between August/2012 and March/2014. Sociodemographic, lifestyle, and biochemical measurements, dietary intake, serum lycopene and α-tocopherol, psoriasis severity according to Psoriasis Area and Severity Index were obtained. Comparisons between serum lycopene and α-tocopherol distributions according to variables were conducted using a one-way analysis of variance. Multiple linear regression was used to investigate factors associated with serum antioxidants. Results: 81 participants (56% female, 62% non-white), 34% without psoriatic lesions, 51% diagnosed with mild psoriasis, and 15% with moderate psoriasis. Median (IQR) age of 54 (41, 62) years, 10 (4, 11) years of education, 17% smokers, 46% overweight and 25% obesity. In total, 72% did not reach the daily recommendation of fruit and vegetable intake. Serum lycopene and α-tocopherol were 0.2 (0.1–0.3) µmol/L and 22.5 (18.5–25.6) µmol/L, respectively. Only 14% presented adequate concentration of lycopene, but adequate α-tocopherol level was observed among 88%. Conclusions: Patients reported a diet low in vegetables and fruits and rich in ultra-processed foods and fatty acids. Adequate circulating α-tocopherol but low serum lycopene, was observed among patients. A linear trend was observed for lycopene according to the severity of psoriasis.
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ISSN:0260-1060
2047-945X
DOI:10.1177/02601060211014127