Search Results - "Rocco, P R"

Angiotensin‐(1‐7) attenuates airway remodelling and hyperresponsiveness in a model of chronic allergic lung inflammation by Magalhães, G S, Rodrigues‐Machado, M G, Motta‐Santos, D, Silva, A R, Caliari, M V, Prata, L O, Abreu, S C, Rocco, P R M, Barcelos, L S, Santos, R A S, Campagnole‐Santos, M J

“…Background and Purpose A long‐term imbalance between pro‐ and anti‐inflammatory mediators leads to airway remodelling, which is strongly correlated to most of…”
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Mesenchymal stem/stromal cell-based therapies for severe viral pneumonia: therapeutic potential and challenges by Masterson, C. H., Ceccato, A., Artigas, A., dos Santos, C., Rocco, P. R., Rolandsson Enes, S., Weiss, D. J., McAuley, D., Matthay, M. A., English, K., Curley, G. F., Laffey, J. G.

“…Severe viral pneumonia is a significant cause of morbidity and mortality globally, whether due to outbreaks of endemic viruses, periodic viral epidemics, or…”
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Therapeutic administration of bone marrow‐derived mesenchymal stromal cells reduces airway inflammation without up‐regulating Tregs in experimental asthma by Kitoko, J. Z., de Castro, L. L., Nascimento, A. P., Abreu, S. C., Cruz, F. F., Arantes, A. C., Xisto, D. G., Martins, M. A., Morales, M. M., Rocco, P. R. M., Olsen, P. C.

“…Summary Background Prophylactic administration of mesenchymal stromal cells (MSCs) derived from adipose (AD‐MSC) and bone marrow tissue (BM‐MSC) in…”
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Early short-term versus prolonged low-dose methylprednisolone therapy in acute lung injury by Silva, P. L, Garcia, C. S. N. B, Maronas, P. A, Cagido, V. R, Negri, E. M, Damaceno-Rodrigues, N. R, Ventura, G. M, Bozza, P. T, Zin, W. A, Capelozzi, V. L, Pelosi, P, Rocco, P. R. M

“…The present study compared the effects of early short-term with prolonged low-dose corticosteroid therapy in acute lung injury (ALI). In total, 120 BALB/c mice…”
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Single and repeated bleomycin intratracheal instillations lead to different biomechanical changes in lung tissue by Pinart, M, Serrano-Mollar, A, Llatjós, R, Rocco, P.R.M, Romero, P.V

“…Abstract Single dose of bleomycin induces acute alveolitis followed by a reparative process whilst a repeated dose results in progressive fibrosis, which may…”
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Recruitment maneuver: RAMP versus CPAP pressure profile in a model of acute lung injury by Riva, D.R, Contador, R.S, Baez-Garcia, C.S.N, Xisto, D.G, Cagido, V.R, Martini, S.V, Morales, M.M, Rocco, P.R.M, Faffe, D.S, Zin, W.A

“…Abstract We examined whether recruitment maneuvers (RMs) with gradual increase in airway pressure (RAMP) provide better outcome than continuous positive airway…”
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Effects of propofol on respiratory mechanic and lung histology in normal rats by Peratoner, A, Nascimento, C.S., Santana, M.C.E., Cadete, R.A., Negri, E.M., Gullo, A, Rocco, P.R.M., Zin, W.A.

“…Propofol is able to reduce airway resistance in lungs with previous airway constriction. The aim of this study was to evaluate the effects of propofol on…”
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Comparison of different degrees of variability in tidal volume to prevent deterioration of respiratory system elastance in experimental acute lung inflammation by Kiss, T, Silva, P.L., Huhle, R, Moraes, L, Santos, R.S., Felix, N.S., Santos, C.L., Morales, M.M., Capelozzi, V.L., Kasper, M, Pelosi, P, Gama de Abreu, M, Rocco, P.R.M.

“…Variable ventilation improves respiratory function, but it is not known whether the amount of variability in tidal volume (VT) can be reduced in recruited…”
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Inflammatory related changes in lung tissue mechanics after bleomycin-induced lung injury by Pinart, M, Serrano-Mollar, A, Negri, E.M, Cabrera, R, Rocco, P.R.M, Romero, P.V

“…Abstract The impact of lung remodelling in respiratory mechanics has been widely studied in bleomycin-induced lung injury. However, little is known regarding…”
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The tyrosine kinase inhibitor dasatinib reduces lung inflammation and remodelling in experimental allergic asthma by Silva, AL, Magalhães, RF, Branco, VC, Silva, JD, Cruz, FF, Marques, PS, Ferreira, TPT, Morales, MM, Martins, MA, Olsen, PC, Rocco, PRM

“…Background and Purpose Asthma is characterized by chronic lung inflammation and airway hyperresponsiveness. Despite recent advances in understanding of its…”
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Bone marrow-derived mononuclear cell therapy attenuates silica-induced lung fibrosis by Maron-Gutierrez, T, Castiglione, R C, Xisto, D G, Oliveira, M G, Cruz, F F, Peçanha, R, Carreira-Junior, H, Ornellas, D S, Moraes, M O, Takiya, C M, Rocco, P R M, Morales, M M

“…This study tests the hypothesis that bone marrow-derived mononuclear cell (BMDMC) therapy may reduce lung inflammation and fibrosis leading to an improvement…”
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Lung parenchyma remodeling in acute respiratory distress syndrome by Rocco, P R M, Dos Santos, C, Pelosi, P

“…Acute respiratory distress syndrome (ARDS), the most severe manifestation of acute lung injury (ALI), is described as a stereotyped response to lung injury…”
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Role of the extracellular matrix in the genesis of ventilator-induced lung injury by Cruz, F. F., Rocco, P. R. M., Pelosi, P.

“…The extracellular matrix represents the three-dimensional scaffold of the alveolar wall, which is composed of a layer of epithelial and endothelial cells,…”
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Regular and moderate aerobic training before allergic asthma induction reduces lung inflammation and remodeling by de Araújo, C. C., Marques, P. S, Silva, J. D., Samary, C. S., da Silva, A. L., Henriques, I., Antunes, M. A., de Oliveira, M. V., Goldenberg, R. C., Morales, M. M., Abreu, I., Diaz, B. L., Rocha, N. N., Capelozzi, V. L., Rocco, P. R. M.

“…Experimental studies have reported that aerobic exercise after asthma induction reduces lung inflammation and remodeling. Nevertheless, no experimental study…”
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Effects of inhalational anaesthetics in experimental allergic asthma by Burburan, S. M., Silva, J. D., Abreu, S. C., Samary, C. S., Guimarães, I. H. L., Xisto, D. G., Morales, M. M., Rocco, P. R. M.

“…Summary We evaluated whether isoflurane, halothane and sevoflurane attenuate the inflammatory response and improve lung morphofunction in experimental asthma…”
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Mechanical ventilation in obese patients by Leme Silva, P, Pelosi, P, Rocco, P R M

“…Recent data show an alarming increasing trend in obesity around the world. Mechanical ventilation in this population requires specific ventilatory settings due…”
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Respiratory effects of lipopolysaccharide-induced inflammatory lung injury in mice by Faffe, DS, Seidl, VR, Chagas, PS, Goncalves de Moraes, VL, Capelozzi, VL, Rocco, PR, Zin, WA

“…The pathogenic mechanisms of lipopolysaccharide (LPS)-induced lung injury have not been classified. This study examined the physiological changes after…”
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Distensibility index of the inferior vena cava in experimental acute respiratory distress syndrome by Mendes, R, Oliveira, M.V, Padilha, G.A, Santos, R.S, Rocha, N.N, Luiz, R.R, Abreu, M.G, Pelosi, P, Rocco, P.R.M, Silva, P.L

“…Highlights • An index of vena cava distensibility (dIVC) has been used in patients with ARDS to detect fluid responsiveness. • dIVC threshold used in rats with…”
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Effects of acute hypercapnia with and without acidosis on lung inflammation and apoptosis in experimental acute lung injury by Nardelli, L.M, Rzezinski, A, Silva, J.D, Maron-Gutierrez, T, Ornellas, D.S, Henriques, I, Capelozzi, V.L, Teodoro, W, Morales, M.M, Silva, P.L, Pelosi, P, Garcia, C.S.N.B, Rocco, P.R.M

“…Highlights • Therapeutic hypercapnia with and without acidosis reduced diffuse alveolar damage. • Hypercapnia decreased interleukin-6 and interleukin-1β…”
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Anaesthetic management in asthma by Burburan, S M, Xisto, D G, Rocco, P R M

“…Anaesthetic management in asthmatic patients has been focused on avoiding bronchoconstriction and inducing bronchodilation. However, the definition of asthma…”
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