Search Results - "Rocchi, Palma"

Coronavirus RNA Proofreading: Molecular Basis and Therapeutic Targeting by Robson, Fran, Khan, Khadija Shahed, Le, Thi Khanh, Paris, Clément, Demirbag, Sinem, Barfuss, Peter, Rocchi, Palma, Ng, Wai-Lung

“…The coronavirus disease 2019 (COVID-19) that is wreaking havoc on worldwide public health and economies has heightened awareness about the lack of effective…”
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Coronavirus RNA Proofreading: Molecular Basis and Therapeutic Targeting by Robson, Fran, Khan, Khadija Shahed, Le, Thi Khanh, Paris, Clément, Demirbag, Sinem, Barfuss, Peter, Rocchi, Palma, Ng, Wai-Lung

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Anticancer drug nanomicelles formed by self-assembling amphiphilic dendrimer to combat cancer drug resistance by Wei, Tuo, Chen, Chao, Liu, Juan, Liu, Cheng, Posocco, Paola, Liu, Xiaoxuan, Cheng, Qiang, Huo, Shuaidong, Liang, Zicai, Fermeglia, Maurizio, Pricl, Sabrina, Liang, Xing-Jie, Rocchi, Palma, Peng, Ling

“…Drug resistance and toxicity constitute challenging hurdles for cancer therapy. The application of nanotechnology for anticancer drug delivery is expected to…”
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Inherent and Tumor-Driven Immune Tolerance in the Prostate Microenvironment Impairs Natural Killer Cell Antitumor Activity by Pasero, Christine, Gravis, Gwenaëlle, Guerin, Mathilde, Granjeaud, Samuel, Thomassin-Piana, Jeanne, Rocchi, Palma, Paciencia-Gros, Maria, Poizat, Flora, Bentobji, Mélanie, Azario-Cheillan, Francine, Walz, Jochen, Salem, Naji, Brunelle, Serge, Moretta, Alessandro, Olive, Daniel

“…The field of immunotherapy for solid tumors, such as prostate cancer, has been recently focusing on therapies that can counter tumor-mediated…”
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Menin inhibition suppresses castration-resistant prostate cancer and enhances chemosensitivity by Cherif, Chaïma, Nguyen, Dang Tan, Paris, Clément, Le, Thi Khanh, Sefiane, Thibaud, Carbuccia, Nadine, Finetti, Pascal, Chaffanet, Max, kaoutari, Abdessamad El, Vernerey, Julien, Fazli, Ladan, Gleave, Martin, Manai, Mohamed, Barthélémy, Philippe, Birnbaum, Daniel, Bertucci, François, Taïeb, David, Rocchi, Palma

“…Disease progression and therapeutic resistance of prostate cancer (PC) are linked to multiple molecular events that promote survival and plasticity. We…”
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An Amphiphilic Dendrimer for Effective Delivery of Small Interfering RNA and Gene Silencing In Vitro and In Vivo by Yu, Tianzhu, Liu, Xiaoxuan, Bolcato-Bellemin, Anne-Laure, Wang, Yang, Liu, Cheng, Erbacher, Patrick, Qu, Fanqi, Rocchi, Palma, Behr, Jean-Paul, Peng, Ling

“…An amphiphilic dendrimer bearing a hydrophobic alkyl chain and hydrophilic poly(amidoamine) dendrons is able to combine the advantageous features of lipid and…”
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The hallmarks of castration-resistant prostate cancers by Katsogiannou, Maria, Ziouziou, Hajer, Karaki, Sara, Andrieu, Claudia, Henry de Villeneuve, Marie, Rocchi, Palma

“…Highlights • Many mechanisms induce the emergence of the castration resistant. • The androgen receptor-related mechanisms. • The latest evidence of the…”
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A Fluorinated Bola-Amphiphilic Dendrimer for On-Demand Delivery of siRNA, via Specific Response to Reactive Oxygen Species by Liu, Xiaoxuan, Wang, Yang, Chen, Chao, Tintaru, Aura, Cao, Yu, Liu, Juan, Ziarelli, Fabio, Tang, Jingjie, Guo, Hongbo, Rosas, Roseline, Giorgio, Suzanne, Charles, Laurence, Rocchi, Palma, Peng, Ling

“…Functional materials capable of responding to stimuli intrinsic to diseases are extremely important for specific drug delivery at the disease site. However,…”
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Mastering Dendrimer Self-Assembly for Efficient siRNA Delivery: From Conceptual Design to In Vivo Efficient Gene Silencing by Chen, Chao, Posocco, Paola, Liu, Xiaoxuan, Cheng, Qiang, Laurini, Erik, Zhou, Jiehua, Liu, Cheng, Wang, Yang, Tang, Jingjie, Col, Valentina Dal, Yu, Tianzhu, Giorgio, Suzanne, Fermeglia, Maurizio, Qu, Fanqi, Liang, Zicai, Rossi, John J., Liu, Minghua, Rocchi, Palma, Pricl, Sabrina, Peng, Ling

“…Self‐assembly is a fundamental concept and a powerful approach in molecular science. However, creating functional materials with the desired properties through…”
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Hsp27 as a therapeutic target in cancers by Acunzo, Julie, Andrieu, Claudia, Baylot, Virginie, So, Alan, Rocchi, Palma

“…Heat shock protein 27 (Hsp27), induced by heat shock, environmental and pathophysiological stressors, is a multidimensional protein that acts as a protein…”
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Structurally flexible triethanolamine-core poly(amidoamine) dendrimers as effective nanovectors to deliver RNAi-based therapeutics by Liu, Xiaoxuan, Liu, Cheng, Catapano, Carlo V., Peng, Ling, Zhou, Jiehua, Rocchi, Palma

“…RNAi-based nucleic acid molecules have attracted considerable attention as compelling therapeutics providing safe and competent delivery systems are available…”
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The Eukaryotic Translation Initiation Factor 4E (eIF4E) as a Therapeutic Target for Cancer by Karaki, Sara, Andrieu, Claudia, Ziouziou, Hajer, Rocchi, Palma

“…Cancer cells depend on cap-dependent translation more than normal tissue. This explains the emergence of proteins involved in the cap-dependent translation as…”
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Tumor protein 53-induced nuclear protein 1 expression is repressed by miR-155, and its restoration inhibits pancreatic tumor development by Gironella, Meritxell, Seux, Mylène, Xie, Min-Jue, Cano, Carla, Tomasini, Richard, Gommeaux, Julien, Garcia, Stephane, Nowak, Jonathan, Yeung, Man Lung, Jeang, Kuan-Teh, Chaix, Amandine, Fazli, Ladan, Motoo, Yoshiharu, Wang, Qing, Rocchi, Palma, Russo, Antonio, Gleave, Martin, Dagorn, Jean-Charles, Iovanna, Juan L, Carrier, Alice, Pébusque, Marie-Josèphe, Dusetti, Nelson J

“…Pancreatic cancer is a disease with an extremely poor prognosis. Tumor protein 53-induced nuclear protein 1 (TP53INP1) is a proapoptotic stress-induced p53…”
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Integrative proteomic and phosphoproteomic profiling of prostate cell lines by Katsogiannou, Maria, Boyer, Jean-Baptiste, Valdeolivas, Alberto, Remy, Elisabeth, Calzone, Laurence, Audebert, Stéphane, Rocchi, Palma, Camoin, Luc, Baudot, Anaïs

“…Prostate cancer is a major public health issue, mainly because patients relapse after androgen deprivation therapy. Proteomic strategies, aiming to reflect the…”
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Hsp27 knockdown using nucleotide-based therapies inhibit tumor growth and enhance chemotherapy in human bladder cancer cells by Kamada, Masayuki, So, Alan, Muramaki, Mototsugu, Rocchi, Palma, Beraldi, Eliana, Gleave, Martin

“…Heat shock protein 27 (Hsp27) is a cytoprotective chaperone that is phosphoactivated during cell stress that prevents aggregation and/or regulate activity and…”
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Between hope and reality: treatment of genetic diseases through nucleic acid-based drugs by Baylot, Virginie, Le, Thi Khanh, Taïeb, David, Rocchi, Palma, Colleaux, Laurence

“…Rare diseases (RD) affect a small number of people compared to the general population and are mostly genetic in origin. The first clinical signs often appear…”
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Nanovectorization of Prostate Cancer Treatment Strategies: A New Approach to Improved Outcomes by Omabe, Kenneth, Paris, Clément, Lannes, François, Taïeb, David, Rocchi, Palma

“…Prostate cancer (PC) is the most frequent male cancer in the Western world. Progression to Castration Resistant Prostate Cancer (CRPC) is a known consequence…”
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Targeted delivery of Dicer-substrate siRNAs using a dual targeting peptide decorated dendrimer delivery system by Liu, Xiaoxuan, PhD, Liu, Cheng, Chen, Chao, Bentobji, Mélanie, Cheillan, Francine Azario, Piana, Jeanne Thomassin, MD, Qu, Fanqi, Rocchi, Palma, PhD, Peng, Ling, PhD

“…Abstract Small interfering RNAs (siRNA) are emerging as novel therapeutic agents, providing competent delivery systems that are available. Dendrimers, a…”
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Efficient Delivery of Sticky siRNA and Potent Gene Silencing in a Prostate Cancer Model Using a Generation 5 Triethanolamine-Core PAMAM Dendrimer by Liu, Xiaoxuan, Liu, Cheng, Laurini, Erik, Posocco, Paola, Pricl, Sabrina, Qu, Fanqi, Rocchi, Palma, Peng, Ling

“…Successful achievement of RNA interference in therapeutic applications requires safe and efficient vectors for siRNA delivery. In the present study, we…”
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Enhanced Antisense Oligonucleotide Delivery Using Cationic Liposomes Grafted with Trastuzumab: A Proof-of-Concept Study in Prostate Cancer by Sicard, Guillaume, Paris, Clément, Giacometti, Sarah, Rodallec, Anne, Ciccolini, Joseph, Rocchi, Palma, Fanciullino, Raphaëlle

“…Prostate cancer (PCa) is the second most common cancer in men worldwide and the fifth leading cause of death by cancer. The overexpression of TCTP protein…”
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